| 脱氧雪腐镰刀菌烯醇毒理作用研究进展 |
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| 引用本文： | 伍力,尹杰,冯泽猛,何流琴,崔志杰,李铁军,印遇龙.脱氧雪腐镰刀菌烯醇毒理作用研究进展[J].生态毒理学报,2013,8(3):331-337. |
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| 作者姓名： | 伍力 尹杰 冯泽猛 何流琴 崔志杰 李铁军 印遇龙 |
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| 作者单位： | 中国科学院亚热带农业生态研究所中国科学院亚热带农业生态过程重点实验室湖南省畜禽健康养殖工程技术中心农业部中南动物营养与饲料科学观测实验站,长沙,410125 |
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| 基金项目： | 国家973重点基础研究发展计划"畜禽产品中有害物质形成原理与控制途径研究"(2009CB118806);国家自然科学基金面上项目"假单胞菌解毒酶降解饲料中呕吐毒素的作用机制"(31072042) |
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| 摘 要： | 脱氧雪腐镰刀菌烯醇(DON)是人畜食品中检出率和超标率最高的一种真菌毒素。与核糖体60s亚基的肽基转移酶活性中心结合后会引发核糖体应激反应,诱导细胞凋亡等作用,对肠道、免疫系统造成破坏,并且具有遗传毒性。为今后的研究工作提供参考,笔者将从DON的毒理学机制和对机体的影响角度入手对近几年新的研究成果做综合论述。
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| 关 键 词： | 脱氧雪腐镰刀菌烯醇 细胞凋亡 免疫 致畸性 |
| 收稿时间： | 2012/12/25 0:00:00 |
| 修稿时间： | 2013/1/17 0:00:00 |
Progress in Research of Toxicological Effects of Deoxynivalenol |
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| Wu Li,Yin Jie,Feng Zemeng,He Liuqin,Cui Zhijie,Li Tiejun and Yin Yulong.Progress in Research of Toxicological Effects of Deoxynivalenol[J].Asian Journal of Ecotoxicology,2013,8(3):331-337. |
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| Authors: | Wu Li Yin Jie Feng Zemeng He Liuqin Cui Zhijie Li Tiejun and Yin Yulong |
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| Institution: | Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory of Agro-Ecological Processes in Subtropical Region of Chinese Academic of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central of Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory of Agro-Ecological Processes in Subtropical Region of Chinese Academic of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central of Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory of Agro-Ecological Processes in Subtropical Region of Chinese Academic of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central of Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory of Agro-Ecological Processes in Subtropical Region of Chinese Academic of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central of Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory of Agro-Ecological Processes in Subtropical Region of Chinese Academic of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central of Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory of Agro-Ecological Processes in Subtropical Region of Chinese Academic of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central of Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory of Agro-Ecological Processes in Subtropical Region of Chinese Academic of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central of Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China |
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| Abstract: | Deoxynivalenol (DON) is one of the mycotoxin, which has the highest detectable rate and exceeding standard rate in human and animal food stuff. Combined with the peptidyl transferase of the ribosomal 60s subunit, DON could trigger intestinal and immune dysfunction, ribosomal stress, cell apoptosis, and had genetic toxicity. To make a reference for the further research, the toxicological mechanisms and the effects of DON on organisms were summarized. |
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| Keywords: | deoxynivalenol cell apoptosis immunity teratogenicity |
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