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立方体和八面体微/纳米氧化亚铜对大型水蚤(Daphnia magna)的氧化胁迫和生理损伤
引用本文:范文宏,刘通,史志伟,王惠惠,汪笑龙.立方体和八面体微/纳米氧化亚铜对大型水蚤(Daphnia magna)的氧化胁迫和生理损伤[J].生态毒理学报,2016,11(5):40-48.
作者姓名:范文宏  刘通  史志伟  王惠惠  汪笑龙
作者单位:北京航空航天大学空间与环境学院,北京,100191
基金项目:国家自然科学基金项目(51378041);教育部博士点基金博导项目(20131102110035)
摘    要:为了实现特定的功能和应用,越来越多不同结构特性的纳米材料逐渐被人们精确合成。一些研究指出纳米材料的物理化学特性能够显著影响纳米材料对水生生物的毒性作用,但是对于不同特性的纳米氧化亚铜的毒性研究依然比较缺乏。本研究制备了2种不同形貌和结构的微/纳米氧化亚铜(micro/nano-Cu_2O)晶体,通过对大型水蚤(Daphnia magna)进行72 h的急性暴露实验,测定了大型水蚤体内还原型谷胱甘肽(GSH)的含量以及超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和钠/钾腺苷三磷酸酶(Na+/K+-ATPase)的活性变化。结果表明在2种不同特性的微/纳米氧化亚铜暴露体系中,大型水蚤体内Cu的积累量差别不大,但是不同结构的micro/nano-Cu_2O对大型水蚤抗氧化酶活性和钠/钾腺苷三磷酸酶活性影响存在差别。与立方体相比,八面体micro/nano-Cu_2O能够暴露更多的{111}面,并且其原子排列使其具有较高的表面能量,因此更容易在大型水蚤肠道内诱导产生活性氧(ROS)及溶出更多Cu2+,对大型水蚤产生更强的氧化胁迫和膜损伤。

关 键 词:微/纳米氧化亚铜  大型水蚤  晶体结构  氧化应激  膜损伤
收稿时间:4/6/2016 12:00:00 AM
修稿时间:2016/5/11 0:00:00

Oxidative Stress and Physiological Damage of Cubic and Octahedral Cu2O Micro/nanocrystals to Daphnia magna
Fan Wenhong,Liu Tong,Shi Zhiwei,Wang Huihui,Wang Xiaolong.Oxidative Stress and Physiological Damage of Cubic and Octahedral Cu2O Micro/nanocrystals to Daphnia magna[J].Asian Journal of Ecotoxicology,2016,11(5):40-48.
Authors:Fan Wenhong  Liu Tong  Shi Zhiwei  Wang Huihui  Wang Xiaolong
Institution:School of Space and Environment, Beihang University, Beijing 100191, China
Abstract:To achieve particular functions and applications, more and more nanomaterials with unique structural characteristics were precisely synthetized. Some studies showed that the physicochemical characteristics of nanomaterials can significantly influence their toxicity to aquatic organisms. However, the researches about nano-Cu2O with different characteristics are rarely reported. In current study, two micro/nano-Cu2O crystals with different structure and shape (cubic and octahedral) were synthesized and investigated for their toxicity towards Daphnia magna. After 72 h exposure, the Cu accumulation, reduced glutathione (GSH) content, and the activities of superoxide dismutase (SOD), catalase (CAT), and Na+/K+-adenosine triphosphatase (Na+/K+-ATPase) in Daphnia magna were measured. It was shown that the Cu accumulation in D. magna had no significant difference with the exposure of cubic and octahedral micro/nano-Cu2O, but the activities of antioxidase and Na+/K+-ATPase differed dramatically. It was concluded that octahedral micro/nano-Cu2O could lead to more serious oxidative stress and membrane damage to D. magna. The possible explanation is that the octahedral micro/nano-Cu2O could induce higher level of ROS and release more copper ions in the intestine, as the result of exposure of more {111} surfaces and higher surface energy than the cubic micro/nano-Cu2O.
Keywords:micro/nano-Cu2O crystals  Daphnia magna  crystal structure  oxidative stress  membrane damage
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