环境内分泌干扰物低剂量-效应研究进展

环境内分泌干扰物(EDCs)的低剂量-效应已成为生态毒理学界的研究热点.环境内分泌干扰物在接近或低于无可见不良效应浓度水平(NOAEL)时仍可诱发生物效应并存在非单调剂量-效应关系,这对现行的动物繁殖和发育毒理学检测规程以及环境内分泌干扰物风险评价的理论和方法提出了挑战.此外,由于环境中内分泌干扰物呈低剂量长期暴露的特征,研究低剂量-效应对正确进行生态风险评价具有重大的科学意义.在总结国内外相关研究的基础上,对当前环境内分泌干扰物低剂量-效应的研究进展进行了综述.

Research Progress in the Low-Dose Effects of Environmental Endocrine Disrupting Chemicals

Recently, the low-dose effects of environmental endocrine disrupting chemicals(EDCs)have become a hot topic within the environmental scientific community. The findings of low-dose(near or below its NOAEL)effects, as well as the non-monotonic dose-response relationship are problematic for risk assessment methods used by regulatory agencies, because they challenge the traditional use of extrapolation from high dose testing to predict responses at the much lower environmentally relevant doses which are within the range of current exposures to numerous chemicals in wildlife and humans. In addition, the exposures to environmental endocrine disrupting chemicals are characterized by low-dose and long-term, so, it's necessary to elucidate the low-dose effects and assess the risk of the consequence on health in a scientific way.