| 孕哺期全氟辛烷磺酸染毒对大鼠海马细胞钙稳态的影响 |
| |
| 引用本文： | 刘晓晖,刘冰,金一和.孕哺期全氟辛烷磺酸染毒对大鼠海马细胞钙稳态的影响[J].生态毒理学报,2011,6(1):67-73. |
| |
| 作者姓名： | 刘晓晖 刘冰 金一和 |
| |
| 作者单位： | 大连理工大学环境学院 工业生态与环境工程教育部重点实验室，大连 116024;辽宁药联制药有限公司，沈阳 110001;大连理工大学环境学院 工业生态与环境工程教育部重点实验室，大连 116024 |
| |
| 基金项目： | 国家自然科学基金项目(No. 20877106) |
| |
| 摘 要： | 为了阐明孕哺期全氟辛烷磺酸(perfluorooctane sulfonate,PFOS)染毒对大鼠及其仔鼠海马细胞钙稳态的影响,将妊娠Wistar大鼠30只,从妊娠第1天开始对实验组分别以72 mg·kg-1(low,L)、14.4 mg·kg-1(high,H)(以饲料中的PFOS计)的PFOS进行染毒至仔鼠生后3...
|
| 关 键 词： | 全氟辛烷磺酸 海马 钙离子 神经毒性 |
| 收稿时间： | 2010/8/27 0:00:00 |
| 修稿时间： | 2010/10/18 0:00:00 |
Effect of Perinatal PFOS Exposure on Intracellular Free Calcium Concentration in Hippocampus of Rats |
| |
| Liu Xiaohui,Liu Bing and Jin Yihe.Effect of Perinatal PFOS Exposure on Intracellular Free Calcium Concentration in Hippocampus of Rats[J].Asian Journal of Ecotoxicology,2011,6(1):67-73. |
| |
| Authors: | Liu Xiaohui Liu Bing and Jin Yihe |
| |
| Institution: | 1,1.School of Environmental Science and Technology,Dalian University of Technology,Key Laboratory of Industrial Ecology and Environmental Engineering,Ministry of Education,Dalian 116024,China2.Liaoning Union Pharmaceutical Limited Cornpany,Shenyang 110001,China |
| |
| Abstract: | Effect of perinatal exposure to PFOS on calcium concentration in hippocampus of Wistar rats was investigated.The pregnant rats were exposed to PFOS with doses of 0 mg·kg-1(control,C),7.2 mg·kg-1(low,L) or 14.4 mg·kg-1(high,H) food from pregnancy day 1 to postnatal day 35.The concentration of PFOS was detected by HPLC/MS-MIS,\Ca2+\]i was determined with Fura-2/AM fluorescence probe.The results show that PFOS can be concentrated in hippocampus of rats.\Ca2+\]i in 7.2 and 14.4 mg·kg-1 PFOS-treated group were(175.4±11.9),(313.4±18.7) nmol·L-1,which were significantly higher than(155.6±11.9) nmol·L-1 in the control(p<0.05).At PND1,\Ca2+\]i in the high group was significantly higher than control(p<0.01).\Ca2+\]i in the HH group was significantly higher than that in CC and LL at PND28 and PND35(p<0.01),respectively.\Ca2+\]i in the HC group was obviously higher than that in the LC and CC group at PND28 and 35(p<0.01),respectively.In addition,with the days increased,\Ca2+\]i in the PFOS exposure group increased significantly(p<0.05).The results show that \Ca2+\]i increased in hippocampus of rats not only in the adults,but also in pups exposure to PFOS with different times,which might have a neurotoxic effect on central nervous system. |
| |
| Keywords: | perfluorooctane sulfonate hippocampus calcium neurotoxicity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《生态毒理学报》浏览原始摘要信息 |
| 点击此处可从《生态毒理学报》下载免费的PDF全文 |
|
