| 燃煤型砷中毒病区尿砷甲基化代谢和砷致皮肤损伤危险度的关系初探 |
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| 引用本文： | 高健伟,虞江萍,韦炳干,柴园庆,杨林生.燃煤型砷中毒病区尿砷甲基化代谢和砷致皮肤损伤危险度的关系初探[J].生态毒理学报,2014,9(6):1197-1203. |
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| 作者姓名： | 高健伟 虞江萍 韦炳干 柴园庆 杨林生 |
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| 作者单位： | 中国科学院地理科学与资源研究所“陆地表层格局与模拟”院重点实验室,北京,100101 |
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| 基金项目： | 国家自然科学基金重点项目（41230749）：饮水和燃煤砷污染生态系统中砷从环境到人体转化的比较研究 |
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| 摘 要： | 砷中毒具有特异的皮肤损伤特征。为了研究燃煤型砷中毒病区高砷暴露、人体甲基化代谢能力与皮肤损伤患病风险之间的关系,在陕南典型燃煤型砷中毒村进行了皮肤损伤诊断和流行病学调查,采集尿样并分析总砷及形态砷含量,同时计算了用于表征人体砷甲基化代谢能力的指标包括尿中无机砷、一甲基砷和二甲基砷占总砷的百分含量(i As%、MMA%、DMA%),以及一甲基化率(PMI=MMA/i As)和二甲基化率(SMI=DMA/MMA)。Logistic回归分析结果表明:尿总砷含量(UTAs)是砷致皮肤损伤的危险因素(OR=1.038,95%CI:1.003~1.073),二甲基砷百分含量和SMI是皮肤损伤的保护因素(OR=0.883,95%CI:0.798~0.976;OR=0.724,95%CI:0.535~0.978);且砷致皮肤损伤的危险度随砷暴露水平的增高和甲基化能力的降低而增大。
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| 关 键 词： | 尿砷 皮肤损伤 风险 甲基化代谢 logistic回归 燃煤型砷中毒 |
| 收稿时间： | 2014/4/25 0:00:00 |
| 修稿时间： | 2014/5/10 0:00:00 |
Urinary Arsenic Methylation Abilities of Population Exposed to Elevated Arsenic Content Coal Used for Living and Their Relationship with Skin Lesions in A Village,Shaan'xi Province |
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| Gao Jianwei,Yu Jiangping#,Wei Binggan,Chai Yuanqing and Yang Linsheng.Urinary Arsenic Methylation Abilities of Population Exposed to Elevated Arsenic Content Coal Used for Living and Their Relationship with Skin Lesions in A Village,Shaan'xi Province[J].Asian Journal of Ecotoxicology,2014,9(6):1197-1203. |
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| Authors: | Gao Jianwei Yu Jiangping# Wei Binggan Chai Yuanqing and Yang Linsheng |
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| Institution: | Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Science, Beijing 100101, China;Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Science, Beijing 100101, China;Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Science, Beijing 100101, China;Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Science, Beijing 100101, China;Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Science, Beijing 100101, China |
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| Abstract: | |
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| Keywords: | urinary arsenic skin lesions induced by arsenic exposure risk arsenic methylation logistic regression coal-burning arsenism |
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