| 运用QSARs方法比较和预测取代苯类化合物的毒性 |
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| 引用本文： | 于红霞,高松亭.运用QSARs方法比较和预测取代苯类化合物的毒性[J].环境化学,1998,17(5):444-450. |
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| 作者姓名： | 于红霞 高松亭 |
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| 作者单位： | [1]污染控制与资源利用国家重点实验室 [2]南京大学环境科学 |
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| 基金项目： | 国家自然科学基金资助项目. |
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| 摘 要： | 本文运用ＱＳＡＲｓ方法比较了惰性化合物卤代苯和次惰性化合物硝基苯类，苯胺类化合物对金鱼的急性毒性试验，鱼肝脏内控制ＡＴＰ水解的Ｎａ＾＋、Ｋ＾＋－ＡＴＰ酶不知力试验以及发光菌毒性试验。
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| 关 键 词： | 卤代苯 硝基苯 苯胺类 毒性试验 污染物 QSARs |
TOXICITY COMPARISON AND PREDICTION OF THE SUBSTITUTED BENZENES BY QSARs METHOD |
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| Yu Hongxia Gao Songting Feng Jianfang Wei Liping Wang Liansheng.TOXICITY COMPARISON AND PREDICTION OF THE SUBSTITUTED BENZENES BY QSARs METHOD[J].Environmental Chemistry,1998,17(5):444-450. |
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| Authors: | Yu Hongxia Gao Songting Feng Jianfang Wei Liping Wang Liansheng |
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| Abstract: | Quantitative structure-activity relationships of toxicity are discussed as a means of assessing the value of the microtox test which uses the light-emitting bacterium vibrio fisheri (Photobacterium phosphoreum) as a replacement for toxicity testing in higher species. The Microtox test is found to be a good surrogate for testing in fish, for compounds acting by the narcosis mechanism. The fitting and predicted toxic data are close to the observed values of substituted benzenes. |
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| Keywords: | substituted benzenes toxicity testing surrogate |
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