以污水流行病学监测广西某市12个污水处理厂服务区域精神活性物质的消耗量

精神活性物质滥用和使用量逐年递增正成为社会稳定、环境健康新的关注点。准确地估算某一地区这类化合物的消耗总量是管理这类物质的关键。本研究对中国广西某市12个污水处理厂(wastewater treatment plants,WWTPs)服务区域中的8种精神活性物质消耗量进行了调查。首先,采用固相萃取-液相色谱-串联质谱法测定了广西某市12个WWTPs进水中8种精神活性物质的浓度,检测到在<方法检测(method detection limit,MDL)至170.9 ng·L^-1范围内的5种精神活性物质。然后,依据污水流行病学(wastewater-based epidemiology,WBE)进行消耗量反算。结果表明,氯胺酮(ketamine,KET)、吗啡(morphine,MOR)、冰毒(methamphetamine,METH)、摇头丸(3,4-methylenedioxymethamphetamine,MDMA)是主要检出的精神活性物质,平均消耗量分别为682.4、167.8、44.6、11.3 mg·d^-1·1000inh^-1;而可卡因(cocaine,COC)、苯甲酰爱康宁(benzoylecgonine,BE)、甲卡西酮(methcathinone,MC)没有被检出。对WWTPs进水中精神活性物质的残留进行分析,估算这些物质在特定区域的消耗量,为防控风险提供支持。

Estimation of the consumption of psychoactive substances in the service areas of 12 wastewater treatment plants in a city of Guangxi,China using wastewater-based epidemiology

The abuse of psychoactive substances is increasing in the last few years,which has became a new concern for social stability and human health.How to accurately estimate the total amount of psychoactive substances used in a certain area is the key point for the management of these substances.This study investigated the consumption of 8 psychoactive substances in the service areas of 12 wastewater treatment plants(WWTPs)in a city of Guangxi,China.Firstly,the solid phase extraction-liquid chromatography-tandem mass spectrometry was used to determine the concentrations of 8 psychoactive substances in the influent of 12 WWTPs in a city of Guangxi,and 5 psychoactive substances were detected,with the concentrations ranging from-1.Then,back calculation of consumption was conducted,according to the wastewater-based epidemiology(WBE).The results showed that ketamine(KET),morphine(MOR),methamphetamine(METH),and ecstasy(3,4-methylenedioxymethamphetamine,MDMA)were the main psychoactive substances detected,with the average consumption of 682.4,167.8,44.6 and 11.3 mg·d^-1·1000inh^-1,respectively.However,cocaine(COC),benzoylecgonine(BE),and methcathinone(MC)were not detected at all.The residues of psychoactive substances in WWTPs influent were analyzed to estimate the consumption of these substances in specific areas,which contributes to the control and prevention of these psychoactive substances.