| 苯酚、苯胺及其衍生物对斜生栅列藻的急性毒性及QSAR研究 |
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| 引用本文： | 陆光华,袁星,赵元慧.苯酚、苯胺及其衍生物对斜生栅列藻的急性毒性及QSAR研究[J].环境化学,2000,19(3):225-229. |
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| 作者姓名： | 陆光华 袁星 赵元慧 |
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| 作者单位： | 东北师范大学环境科学系,长春,130024 |
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| 基金项目： | 中国科学院资助项目，29877004， |
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| 摘 要： | 本文应用ＯＥＣＤ标准方法测定了１８种酚类胺类化合物对斜生栅列藻的４８ｈ－ＥＣ６０值，选择参数ＥＬＵＭＯ和ｌｇＫｏｗ进行了ＱＳＡＲ分析，得到下列回归方程：－１ｇＥＣ５０＝２．５４１－０．６４９ＥＬＵＭＯ＋０．２９９ＬｇＫｏｗ，ｎ＝１８，ｒ＝０．９０３，ＳＥ＝０．３１４应用所得方程计算了化合物的毒性，探讨了毒机理。
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| 关 键 词： | 苯酚 苯胺 斜生栅列藻 毒性 QSAR |
THE ACUTE TOXICITY OF ANILINE,PHENOL DERIVATIVES TO THE SCENEDESMUS OBLIQUUS AND QSAR STUDY |
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| Lu Guanghua,Yuan Xing,Zhao Yuanhui.THE ACUTE TOXICITY OF ANILINE,PHENOL DERIVATIVES TO THE SCENEDESMUS OBLIQUUS AND QSAR STUDY[J].Environmental Chemistry,2000,19(3):225-229. |
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| Authors: | Lu Guanghua Yuan Xing Zhao Yuanhui |
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| Abstract: | 50% effective inhibition concentration 48h-EC50 values of 18 aniline and phenol derivatives to Scenedesmus obliquus were measured . The qualitative structure - activity relationship ( QSAR ) stu -dies were performed with the toxicity and 2 parameters of ELUMO and lgKow. Satisfactory equation was developed as follow:-IgEC50 = 2.503-0.649ELUMO 0.2991g/Kow n= 18 r = 0.903 SE = 0.314The QASR model was used to estimate the toxicities and discussed the intoxication mechanism. |
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| Keywords: | aniline phenol Scenedesmus obliquus toxicity QSAR |
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