| 甲磺酸帕珠沙星中甲烷磺酸的离子色谱法测定 |
| |
| 引用本文： | 刘京生,史亚利,蔡亚岐,牟世芬.甲磺酸帕珠沙星中甲烷磺酸的离子色谱法测定[J].环境化学,2006,25(5):644-646. |
| |
| 作者姓名： | 刘京生 史亚利 蔡亚岐 牟世芬 |
| |
| 作者单位： | 1. 中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京,100085;戴安中国有限公司应用研究中心,北京,100085
2. 中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京,100085 |
| |
| 摘 要： | 建立了甲磺酸帕珠沙星中甲烷磺酸的离子色谱分析方法.选用亲水性的阴离子交换柱IonPac ASl8作分析柱,在线淋洗液发生器产生的KOH为淋洗液,等度淋洗,电导检测,在10min内完成甲烷磺酸分析.结果表明,在0.7-140mg·l-1范围内线性良好(r2=0.9998),样品峰面积的RSD为0.494%(n=7),回收率为107.2%.方法简便、快速、基体干扰小,可在甲磺酸帕珠沙星产品的检验中发挥重要作用.
|
| 关 键 词： | 离子色谱 甲磺酸帕珠沙星 甲烷磺酸 |
| 收稿时间： | 2006-03-06 |
| 修稿时间： | 2006-03-06 |
DETERMINATION OF METHANESULFONIC ACID IN PAZUFLOXACIN MESYLATE BY ION CHROMATOGRAPHY |
| |
| LIU Jing-sheng,SHI Ya-li,CAI Ya-qi,MOU Shi-fen.DETERMINATION OF METHANESULFONIC ACID IN PAZUFLOXACIN MESYLATE BY ION CHROMATOGRAPHY[J].Environmental Chemistry,2006,25(5):644-646. |
| |
| Authors: | LIU Jing-sheng SHI Ya-li CAI Ya-qi MOU Shi-fen |
| |
| Abstract: | A analytical method for the determination of methanesulfonic acid(MSA)in pazufloxacin mesylate pro-duct was developed by ion chromatography(IC).The determination of MSA was achieved on hydrophilic ion exchange column IonPac AS18 with KOH as eluent,and the detection was performed by a conductivity detection mode.The calibration graph of peak area for MSA was linear in the large ranges.The recovery of added standard was 107.2%.RSD of the peak area of MSA was 0.494%(n=7).The results indicated that the method was simple,rapid,accurate and sensitive for determination of MSA in the sample of pazufloxacin(mesylate). |
| |
| Keywords: | ion chromatography pazufloxacin mesylate methanesulfonic acid |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
