| 羟基多溴联苯醚(3'-OH-BDE-7)的大鼠体外肝代谢研究 |
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| 引用本文： | 赖永权,陈学国,蔡宗苇.羟基多溴联苯醚(3'-OH-BDE-7)的大鼠体外肝代谢研究[J].环境化学,2011,30(1):346-350. |
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| 作者姓名： | 赖永权 陈学国 蔡宗苇 |
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| 作者单位： | 1. 香港浸会大学化学系,香港特别行政区
2. 香港浸会大学化学系,香港特别行政区;中国刑事警察学院法医系,沈阳,110854 |
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| 摘 要： | 本文利用液相色谱-质谱联用技术,建立了羟基多溴联苯醚3'-OH-BDE-7在S.D.大鼠肝匀浆中的体外代谢研究方法.实验结果表明,3'-OH-BDE-7的主要代谢产物为2,4-二溴苯酚和二羟基多溴联苯醚(diOHPBDEs),并且其在温孵30min,时代谢转化率为90%.3'-OH-BDE-7的代谢研究为其它羟基多溴联...
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| 关 键 词： | 多溴联苯醚(PBDEs) 羟基多溴联苯醚(OH-PBDEs) 体外代谢 液相色谱-质谱 |
IN VITRO METABOLISM STUDY OF 3'-OH-2,4-diBDE-7 IN RAT LIVER S9 FRACTION |
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| LAI Yongquan,CHEN Xueguo,CAI Zongwei.IN VITRO METABOLISM STUDY OF 3''-OH-2,4-diBDE-7 IN RAT LIVER S9 FRACTION[J].Environmental Chemistry,2011,30(1):346-350. |
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| Authors: | LAI Yongquan CHEN Xueguo CAI Zongwei |
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| Institution: | LAI Yongquan1 CHEN Xueguo1,2 CAI Zongwei1(1.Department of Chemistry,Hong Kong Baptist University,Hong Kong SAR,China,2.Department of Forensic Medicine,China Criminal Police University,Shenyang,China) |
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| Abstract: | Polybrominated diphenyl ethers(PBDEs) are an important class of brominated flame retardants that have been widely used in industrial and consumer products.PBDEs have become worldwide environmental pollutants because of the bioaccumulation,long-distance transportation and potential biological toxicities.Hydroxylated polybrominated diphenyl ethers(OH-PBDEs) are a relatively new group of phenolic compounds that have attracted particular interest due to their endocrine disrupting potency.OH-PBDEs are similar to... |
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| Keywords: | polybrominated diphenyl ethers(PBDEs) hydroxylated polybrominated diphenyl ethers(OH-PBDEs) in vitro metabolism LC-MS |
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