The toxicological paradigms of aluminum and the etiology of Alzheimer's disease in the nematode Caenorhabditis elegans |
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| Authors: | Vanessa Ecla de Oliveira Ana Paula Vanin Ani Carla Concato Wagner A Tamagno Helen Treichel Rosilene R Kaizer |
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| Institution: | Vanessa Ecléa de Oliveira,Ana Paula Vanin,Ani Carla Concato,Wagner A. Tamagno,Helen Treichel,Rosilene R. Kaizer |
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| Abstract: | This study examined behavioral and enzymatic changes of C. elegans from its exposure to aluminum, and the resulting relationship with Alzheimer's disease. After chronic and acute exposure to aluminum, the results indicated that it alters the cholinergic status and behavior parameters of the nematode, suggesting a relationship between exposure to aluminum and the etiology of AD. |
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| Keywords: | C elegans metals neurodegenerative diseases transgenic strains |
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