Pre- and postnatal exposures to pesticides and neurodevelopmental effects in children living in agricultural communities from South-Eastern Spain |
| |
| Institution: | 1. Andalusian School of Public Health (EASP), Granada, Spain;2. Instituto de Investigación Biosanitaria, ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain;3. Department of Legal Medicine and Toxicology, University of Granada School of Medicine, Granada, Spain;4. Department of Neurosciences, Faculty of Health Sciences, University of Almería, Spain;5. Center for Public Health Research (CSISP-FISABIO), Valencia, Spain;6. Department of Genetics, Faculty of Sciences, University of Granada, Spain;7. University of Almería, Department of Neurosciences and Health Sciences, Almería, Spain;8. Andalusian Council of Health at Almería Province, Almería, Spain;9. CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain;1. Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen, Denmark;2. Department of Environmental Science, Aarhus University, Roskilde, Denmark;3. Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark;4. Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark;1. Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA;2. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA;3. Department of Child Health Care, Children''s Hospital Zhejiang University School of Medicine, Zhejiang, China;4. Department of Psychology, Renmin University of China, Beijing, China;5. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China;1. Department of Physics, Nasarawa State University Keffi, P.M.B 1022 Keffi, Nigeria;2. Department of Physics, Universiti Teknologi Malaysia, 81310 Johor Baru, Malaysia;3. Norwegian Institute for Air Research (NILU), Department of Atmospheric and Climate Research (ATMOS), Kjeller, Norway;4. Environment and Sustainability Program, and Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, United States;5. Faculty of Biotechnology, Chubu University, Kasugai, Japan;6. State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China |
| |
| Abstract: | BackgroundChildrens exposure to neurotoxic compounds poses a major problem to public health because of their actively developing brain that makes them highly vulnerable. However, limited information is available on neuropsychological effects in children associated with pre- and postnatal exposures to pesticides.ObjectiveTo evaluate the association between current and pre- and postnatal exposures to pesticides and their effects on neurodevelopment in children aged 6–11 years living in agricultural communities from South-Eastern Spain.MethodsAn ambispective study was conducted on 305 children aged 6–11 years randomly selected from public schools of the study area. Current exposure to organophosphate pesticides was assessed measuring children's urinary levels of dialkylphosphates (DAPs). Both prenatal and postnatal residential exposure to pesticides was estimated by developing a geographical information system (GIS) technology-based index that integrated distance-weighted measure of agricultural surface, time-series of crop areas per municipality and year, and land-use maps. Neuropsychological performance was evaluated with the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). The association of pre- and postnatal and current pesticide exposure with WISC-IV scale scores was assessed using multivariate linear regression models and generalized estimating equation (GEE) models, respectively.ResultsGreater urinary DAP levels were associated with a poorer performance on intelligence quotient and verbal comprehension domain, with effects being more prominent in boys than in girls. The influence of an increase in 10 ha per year in crop surface around the child's residence during the postnatal period was associated with decreased intelligence quotient, processing speed and verbal comprehension scores. As regards prenatal exposure to pesticides, a poor processing speed performance was observed. These effects were also more prominent in boys than in girls.ConclusionsOur results suggest that postnatal exposure to pesticides can negatively affect children's neuropsychological performance. Prenatal exposure was weakly associated to neurodevelopment impairment. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
