共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
4.
Otto Bossert 《Die Naturwissenschaften》1952,39(23):541-543
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
Hiroshi Morimoto 《Die Naturwissenschaften》1989,76(5):200-205
Syntheses of some metabolites of ubiquinone and of related compounds are described. Idebenone (QSA-10), a methyl-dimethoxy-benzoquinone bearing an omega-hydroxydecyl side chain in 3-position, restored the oxidation of succinate and of NADH in ubiquinone-depleted mitochondrial preparations and showed a stabilizing effect on lysosomal membranes and an inhibitory effect on cAMP-phosphodiesterase. It inhibited lipid peroxidation in canine brain mitochondria and in microsomes from canine brain and rat liver. Administered orally to rats, it increased the respiratory control index for glutamate and succinate oxidation but had no effect on the ADP/O2 ratio. Pharmacological effects of idebenon are also briefly discussed. 相似文献
17.
18.
19.