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1.
An increasing number and amount of pharmaceuticals for human and veterinary use currently reach the aquatic environment, and the determination of their effects on aquatic organisms becomes of major importance. The 96-h fish lethal test is one of the conventional assays required for environmental hazardous assessment, but it is extremely time-consuming and costly, and it raises ethical concerns. In a broad study, we compared the ability of cell-based assays to detect, in absolute terms, lethal toxicity in fish due to pharmaceuticals in order to select sensitive cell lines to be posteriorly used as an alternative to fish testing. This study also explored the sensitivity of the rat cardiomyoblast H9c2(2-1) cell line and the suitability of the sulforhodamine B colorimetric assay regarding 15 pharmaceuticals belonging to 9 different therapeutic classes. The relation between in vivo and in vitro data was expressed as LC50,96h/EC50 ratios, and 66% of concordant data were attained. Accordingly, it was possible to conclude that cell-based assays could be considered a suitable alternative to fish lethal testing for pharmaceuticals, which, after validation, may dramatically reduce the number of fish required for environmental hazardous assessment. Several cell lines were selected as promising alternatives, but H9c2(2-1), HepG2, PLHC-1, and RTG-2 could be considered suitable starting cell types for further studies, as relevant results were obtained with low exposure times. 相似文献
2.
Possible mechanisms to explain endocrine effects on reproduction and sex differentiation are presented for selected pharmaceuticals,
agrochemicals, industrial chemicals and plant sterols which are known to be present in the aquatic environment. Disruptions
of the hormonal coordination can be induced by xenobiotics on various levels of the hierachically organised endocrine system
of vertebrates. Phthalate plasticisers, for example, may disrupt the pituitary control of gonadal functions; prenatal/larval
exposure to synthetic estrogen impairs sex differentiation and neuroendocrine sexual determination of the central nervous
system; phenylurea herbicides block the androgen receptor; the biotransformation of weakly estrogenic plant sterol components
of paper mill wastewater (e.g. βsitosterol) may lead to androgenic compounds. The effect of hypolipidemic drugs on lipid homeostasis
(peroxysom proliferation) is transmitted via a receptor protein that seems to be closely related to the endocrine system both
functionally as well as phylogenetically; possible interferences with the neuroendocrine control of sex differentiation are
also discussed. In invertebrates, tributyltin is known to effect the biosynthesis of steroidal sexual hormones. PCBs are suspected
to be competitive inhibitors of the steroid catabolism.
In order to identify potential risks caused by chemicals to the reproductive capacities of aquatic animals and to the quality
of drinking water, methods should be established to detect endocrine disrupters at the various levels of the endocrine system. 相似文献
3.
Among the many larvicides tested for the control of
s.l. larvae, the vector of human onchocerciasis in West Africa, pyraclofos proved to be 100% effective at 100 μg × L −1 for 10 min in river, with a carry of 20 km at 100 m 3 × sec −1. Tests were then performed both in laboratory and field conditions to evaluate its toxicity on the non-target aquatic fauna. In experimental short-term gutter tests, the detachment of the total benthic insects was 35% at 100 μg × L −1 for 10 min against 17% for temephos at the same dose and 59% for chlorphoxim at 50μg × L −1 for 10 min.
,
and
were the most affected organisms. The treatment of a river resulted in a considerable detachment of the same taxonomic groups, plus Orthocladiinae. On the other hand, investigations conducted in tanks showed that the 24-hr LC 50 for
is 150 μg × L −1 and that for
170 μg × L −1, values which are not very different from the operational dose of the larvicide (100 μg × L −1 for 10 min.). Nevertheless, in a river, no fish mortality was recorded. Based on fish LC 50 and drift of benthic insects, pyraclofos at 100 μg × L −1 was judged to be less toxic to aquatic fauna in the short term than permethrin and carbosulfan. 相似文献
4.
Background, aim, and scope Impacts on the reproductive health of wild fish are thought to be suitable early-warning tools indicating contamination of
surface waters with endocrine-disrupting compounds. Ecotoxicological assessment of these field observations depends on the
availability of reliable biomarkers to enable a discrimination of natural variations of reproductive functions from anthropogenic
impacts. 相似文献
5.
Daphnia magna, Desmodesmus subspicatus and Lemna minor were used to determine the ecotoxicity of beta-blockers. Propranolol was the most toxic substance, with EC50s of 7.7 mg l-1 in the Daphnia test and 0.73 mg l-1 in the algal test. The toxicity of atenolol and metoprolol in the Daphnia test was very low, with EC50s of 313 and 438 mg l-1, respectively. In the algal test, metoprolol (EC50: 7.9 mg l-1) was more toxic than atenolol (EC50: 620 mg l-1). Lemna minor was the least sensitive species. All substances showed PEC/PNEC ratios <1, whereas propranolol with a ratio of 0.81 seems to be the most relevant substance and I recommend to perform chronic biotests to refine the estimate of the environmental risk. Taking bioconcentration factors (BCF) into account, resulting internal effect concentrations (IEC) differ only slightly, which means that the differences in the EC50 depend mainly on the diverse logP levels causing narcosis via disruption of membrane integrity. Predictions of toxicity using ECOSAR were close to the empirically measured data. Mixture toxicity of the three compounds could be predicted accurately using the concept of concentration addition. 相似文献
6.
Environmental Science and Pollution Research - The identification of harmful metal ions in aquatic environments is a global concern since these contaminants can have serious consequences for... 相似文献
7.
In recent years, increasing attention has been paid to the trace-level contamination of pharmaceuticals in the water environment all over the world. Considering a large number of pharmaceuticals used, it is crucial to establish a priority list of pharmaceuticals that should be monitored and/or treated first. In the present study, we developed a ranking system based on the pharmaceutical consumption, removal performance in the wastewater treatment plants (WWTPs) and potential ecological effects, and applied to the situation of China. 39 pharmaceuticals, which had available consumption data and also been reported previously in the WWTPs of China, were selected as candidate pharmaceuticals. Among them, seventeen pharmaceuticals were considered as priority pharmaceuticals, out of which, erythromycin, diclofenac acid and ibuprofen, had the high priority. Compared with other literatures, we found that some pharmaceuticals given concerns to globally should also be included in the priority list in China; while some pharmaceuticals, not mentioned in other literatures, such as cefalexin, ketoconazole, should be also given prior consideration in China. Among all the therapeutic classes, antibiotics, which were grossly abused in China, contributed the most to the priority pharmaceuticals. However, priority antibiotics accounted for only 32% of candidate antibiotics, while 71% and 100% of the candidate anti-inflammatory and antilipidemic respectively were identified as the priority pharmaceuticals, indicating that antibiotics might be overanxiously considered in the previous studies on their behaviors in the WWTPs of China. 相似文献
8.
The rate and extent of ?-caprolactam degradation in aquatic systems are dependent on the nutrient availability, indigenous microbial population and activity, chemical concentration, and water temperature. The labeled chemical evolved 14CO 2 indicating ring cleavage with between 35 and 80% of the radioactivity evolved as 14CO 2 after 21 days in yeast extract-supplemented waters. The percent of caprolactam degraded was indirectly related to the chemical's concentration in the water, suggesting microbial inhibition at high caprolactam concentrations. 相似文献
11.
-- An environmental assessment of the transformation and transport pathways of hexachlorocyclopentadiene (hex) in simulated aquatic ecosystems is presented. Hydrolytic and photolytic disappearance rate constants in distilled and natural waters and in sediment-water systems are given. Sediments in defined sediment-water systems do not significantly affect the disappearance rate constants, compared to distilled water values, for the hydrolytic and photolytic processes. Water solubility, octanol/water partition coefficient, and vapor pressure for hex are also reported and compared with literature values. Fate and transport assessment using an evaluative model indicates that hex will not likely reach substantial steady-state concentrations in the various compartments of the simulated ecosystems. The results also indicate that photolysis and, to a lesser extent, hydrolysis are the predominant degradation processes; export via the water column is the predominant transport process. 相似文献
12.
The consequences of contamination of the aquatic environment by epichlorohydrin have been evaluated by a review of the available scientific data. Epichlorohydrin is a non-persistent chemical, which is not expected to bioaccumulate. Acute aquatic as well as mammalian toxicity is moderate. Epichlorohydrin displays clear mutagenic activity. It has been shown to cause cancer in laboratory animals. 相似文献
13.
The fate of hydrophobic organic pollutants in the aquatic environment is controlled by a variety of physical, chemical and biological processes. Some of the most important are physical transport, chemical and biological transformations, and distribution of these compounds between the various environmental compartments (atmosphere, water, sediments and biota). The major biogeochemical processes that control the fate of hydrophobic organic compounds in the aquatic environment are reviewed. These processes include evaporation, solubilization, interaction with dissolved organic matter, sediment-water partitioning, bioaccumulation and degradation. Physico-chemical parameters used to predict the aquatic fate of such compounds are also discussed. 相似文献
14.
Traditional single species toxicity tests and multiple component laboratory-scaled microcosm assays were combined to assess the toxicological hazard of diesel oil, a model complex mixture, to a model aquatic environment. The immediate impact of diesel oil dosed on a freshwater community was studied in a model pond microcosm over 14 days: a 7-day dosage and a 7-day recovery period. A multicomponent laboratory microcosm was designed to monitor the biological effects of diesel oil (1.0 mg litre(-1)) on four components: water, sediment (soil + microbiota), plants (aquatic macrophytes and algae), and animals (zooplanktonic and zoobenthic invertebrates). To determine the sensitivity of each part of the community to diesel oil contamination and how this model community recovered when the oil dissipated, limnological, toxicological, and microbiological variables were considered. Our model revealed these significant occurrences during the spill period: first, a community production and respiration perturbation, characterized in the water column by a decrease in dissolved oxygen and redox potential and a concomitant increase in alkalinity and conductivity; second, marked changes in microbiota of sediments that included bacterial heterotrophic dominance and a high heterotrophic index (0.6), increased bacterial productivity, and the marked increases in numbers of saprophytic bacteria (10 x) and bacterial oil degraders (1000 x); and third, column water acutely toxic (100% mortality) to two model taxa: Selenastrum capricornutum and Daphnia magna. Following the simulated clean-up procedure to remove the oil slick, the recovery period of this freshwater microcosm was characterized by a return to control values. This experimental design emphasized monitoring toxicological responses in aquatic microcosm; hence, we proposed the term 'toxicosm' to describe this approach to aquatic toxicological hazard evaluation. The toxicosm as a valuable toxicological tool for screening aquatic contaminants was demonstrated using diesel oil as a model complex mixture. 相似文献
15.
In previous studies, boron compounds were considered to be of comparatively low toxicity in the aquatic environment, with predicted no effect concentration (PNEC) values ranging around 1 mg B/L (expressed as boron equivalent). In the present study, we describe an evaluation of toxicity data for boron available for the aquatic environment by different methods.For substances with rich datasets, it is often possible to perform a species sensitivity distribution (SSD). The typical outcome of an SSD is the Hazardous Concentration 5% (HC 5), the concentration at which 95% of all species are protected with a probability of 95%. The data set currently available on the toxic effects of boron compounds to aquatic organisms is comprehensive, but a careful evaluation of these data revealed that chronic data for aquatic insects and plants are missing. In the present study both the standard assessment factor approach as well as the SSD approach were applied. The standard approach led to a PNEC of 0.18 mg B/L (equivalent to 1.03 mg boric acid/L), while the SSD approach resulted in a PNEC of 0.34 mg B/L (equivalent to 1.94 mg boric acid/L). These evaluations indicate that boron compounds could be hazardous to aquatic organisms at concentrations close to the natural environmental background in some European regions. This suggests a possible high sensitivity of some ecosystems for anthropogenic input of boron compounds. Another concern is that the anthropogenic input of boron could lead to toxic effects in organisms adapted to low boron concentration. 相似文献
17.
Lansoprazole and omeprazole degrade in water leading to sulfides, benzimidazolones and a red complex material. Degradation is accelerated in acid medium and by solar simulator irradiation. Benzimidazoles, dianilines and pyridines have also been identified. 相似文献
18.
Aminopolycarboxylic acids, such as ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), diethylenetriaminepentaacetic acid (DTPA), 1,3-propylenediaminetetraacetic acid (1,3-PDTA), beta-alaninediacetic acid (beta-ADA), and methylglycinediacetic acid (MGDA), are used in large quantities in a broad range of industrial applications and domestic products in order to solubilize or inactivate various metal ions by complex formation. Due to the wide field of their application, their high polarity and partly low degradability, these substances reach the aquatic environment at considerable concentrations (in the microg/L-range) and have also been detected in drinking water. This review evaluates and summarizes the results of long-term research projects, monitoring programs, and published papers concerning the pollution of the aquatic environment by aminopolycarboxylates in Germany. Concentrations and loads of aminopolycarboxylates are presented for various types of water including industrial and domestic waste waters, surface waters (rivers and lakes), raw waters, and drinking waters. 相似文献
19.
In this report, we refer to pharmaceuticals that are widespread in the urban aquatic environment and that mainly originate from wastewater treatment plants or non-point source sewage as “wastewater-marking pharmaceuticals” (WWMPs). To some extent, they reflect the condition or trend of water contamination and also contribute to aquatic environmental risk assessment. The method reported here for screening typical WWMPs was proposed based on academic concerns about them and their concentrations present in the urban aquatic environment, as well as their properties of accumulation, persistence, eco-toxicity and related environmental risks caused by them. The screening system consisted of an initial screening system and a further screening system. In the former, pharmaceuticals were categorised into different evaluation levels, and in the latter, each pharmaceutical was given a normalised final evaluation score, which was the sum of every score for its properties of accumulation, persistence, eco-toxicity and environmental risk in the aquatic environment. The system was applied to 126 pharmaceuticals frequently detected in the aquatic environment. In the initial screening procedure, five pharmaceuticals were classified into the “high” category, 16 pharmaceuticals into the “medium” category, 15 pharmaceuticals into the “low” category and 90 pharmaceuticals into the “very low” category. Subsequently, further screening were conducted on 36 pharmaceuticals considered as being of “high”, “medium” and “low” categories in the former system. We identified 7 pharmaceuticals with final evaluation scores of 1–10, 10 pharmaceuticals with scores of 11–15, 15 pharmaceuticals with scores from 16 to 20 and 4 pharmaceuticals with scores above 21. The results showed that this screening system could contribute to the effective selection of target WWMPs, which would be important for spatial-temporal dynamics, transference and pollution control of pharmaceuticals in the urban aquatic environment. However, there remains a number of pharmaceutical parameters with measured data gaps, such as organic carbon adsorption coefficients and bioconcentration factors, which, if filled, would improve the accuracy of the screening system. 相似文献
20.
Over the past 15 years passive sampling devices have been developed that accumulate organic micropollutants and allow detection at ambient sub ng/l concentrations. Most passive accumulation devices (PADs) are designed for 1-4 weeks field deployment, where uptake is governed by linear first order kinetics providing a time weighted average of the exposure concentration. Semipermeable membrane devices (SPMDs) are the most comprehensively studied PADs, but other samplers may also be considered for aquatic monitoring purposes. The applicability of the PADs is reviewed with respect to commonly monitored aqueous matrices and compounds, the detection limits, and for use in quantitative monitoring related to requirements embedded in the EU Water Framework Directive, the US and EU Water Quality Criteria, and the Danish monitoring aquatic programme. The PADs may monitor >75% of the organic micropollutants of the programmes. Research is warranted regarding the uptake in PADs in low flow environments and for the development of samplers for polar organic compounds. 相似文献
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