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According to the toxicity mechanism of the individual chemicals, the concentration addition toxicity mechanism is revealed for nonpolar-narcotic-chemical mixtures, polar-narcotic-chemical mixtures and reactive-chemical mixtures, respectively. For nonpolar-narcotic-chemical mixtures, the partitioning of individual chemicals from water to biophase was determined, and the result shows that their concentration additive effect results from no competitive partitioning among individual chemicals. For polar-narcotic-chemical mixtures, their toxicity are contributed by two factors (the total baseline toxicity and the hydrogen bond donor activity of individual chemicals), and it is the concentration additive effect for either of these two factors that leads to their concentration addition toxicity. In addition, the interactions between the reactive chemicals and the biological macromolecules are discussed thoroughly. The results suggest that the net effect of these interactions is zero, and it is this zero net effect that leads to the concentration addition toxicity mechanism for reactive-chemical mixtures. 相似文献
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Hamdy Balba 《Journal of environmental science and health. Part. B》2013,48(4):441-451
Strobilurins are natural products isolated and identified from specific fungi. Natural strobilurins were named in the order of their discovery as strobilurin-A followed by strobilurin-B, C, D etc. Their discovery opened the door for new chemistry of synthetic fungicides. Applying Quantitative Structural Activity Relationship (QSAR) on the structures of the natural strobilurins, many pesticide companies were able to discover many synthetic analogues that are more efficacious and more stable fungicides. At present there are about eight synthetic strobilurins in the fungicides worldwide market. Some of these products are worldwide registered for use as agrochemical and some are in the process of registration. This class of fungicides is relatively new, as crop protection products and information about them is still fairly scarce. In this review, syntheses and chemistry of natural and synthetic strobilurins are discussed. Also, the mode of action, efficacy, biotic/abiotic degradation, analytical methods, and agricultural uses are discussed. 相似文献
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E. Merian 《Chemosphere》1978,7(4):307-313
This article is a summary from eleven important symposia. In these meetings, critical facts were discussed which are the necessary basis for the important legislation about toxic substances in Europe, in the U.S.A. and in Japan. This review article should also be of some help to the readers of “Chemosphere” for direct contacts with the experts mentioned. It is therefore an informative and coordinative survey, in which chemical and ecotoxicological details are largely omited. 相似文献
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Balba H 《Journal of environmental science and health. Part. B》2007,42(4):441-451
Strobilurins are natural products isolated and identified from specific fungi. Natural strobilurins were named in the order of their discovery as strobilurin-A followed by strobilurin-B, C, D etc. Their discovery opened the door for new chemistry of synthetic fungicides. Applying Quantitative Structural Activity Relationship (QSAR) on the structures of the natural strobilurins, many pesticide companies were able to discover many synthetic analogues that are more efficacious and more stable fungicides. At present there are about eight synthetic strobilurins in the fungicides worldwide market. Some of these products are worldwide registered for use as agrochemical and some are in the process of registration. This class of fungicides is relatively new, as crop protection products and information about them is still fairly scarce. In this review, syntheses and chemistry of natural and synthetic strobilurins are discussed. Also, the mode of action, efficacy, biotic/abiotic degradation, analytical methods, and agricultural uses are discussed. 相似文献
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Harald J. Geyer Derek C. G. Muir Irene Scheunert Christian E. W. Steinberg Antonius A. W. Kettrup 《Environmental science and pollution research international》1994,1(2):75-80
According to present understanding, persistent superlipophilic chemicals — such as octachlorodibenzo-p-dioxin, octachlorodibenzofuran, Mirex etc — with log Kow > 6 and cross sections > 9.5 Å, bioconcentrate in aquatic organisms only little from ambient water. The most convincing argument against it is that in bioconcentration experiments with superlipophilic chemicals amounts applied exceeded water solubility by several orders of magnitude. This paper describes various methods for determining bioconcentration factors (BCF) of superlipophilic compounds. As exemplified with octachlorodibenzo-p-dioxin, BCF values evaluated by these methods match well with those calculated by QSARs for fish and mussels based on log Kow and water solubility. As expected, these BCF values exceed previous values by several orders of magnitude. For BCF evaluation of superlipophilic chemicals in aquatic organisms we recommend:
- flow-through systems, kinetic method (OECD guideline No. 305 E)
- ambient concentrations < water solubility
- during the uptake and especially during the elimination phase no toxic effects of the test organisms should occur.
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Remediation of cadmium contamination in paddy soils by washing with chemicals: selection of washing chemicals 总被引:3,自引:0,他引:3
Makino T Sugahara K Sakurai Y Takano H Kamiya T Sasaki K Itou T Sekiya N 《Environmental pollution (Barking, Essex : 1987)》2006,144(1):2-10
The efficiencies of neutral salts, strong acids, and chelates were tested for extracting cadmium (Cd) from three paddy soils. The higher the selectivity of the cations of the added neutral salts toward soil adsorption sites, the lower the pH in the extracts and the more soil Cd could be extracted. In addition, soil carbon and nitrogen contents and mineral composition were closely associated with the amount of Cd extracted. Calcium chloride and iron(III) chloride were selected as wash chemicals to restore Cd-contaminated paddy soils in situ. Washing with calcium chloride led to the formation of Cd chloride complexes, enhancing Cd extraction from the soils. The washing also substantially decreased soil levels of exchangeable and acid-soluble Cd, which are the major forms of bioavailable Cd for rice (Oryza sativa L.). The optimum conditions for in situ soil washing were also determined for calcium chloride. 相似文献
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Jan Ahlers Robert Diderich Ursula Klaschka Annette Marschner Beatrice Schwarz-Schulz 《Environmental science and pollution research international》1994,1(2):117-123
Most of the existing chemicals of high priority have been released into the environment for many years. Risk assessments for existing chemicals are now conducted within the framework of the German Existing Chemicals Program and by the EC Regulation on Existing Substances. The environmental assessment of a chemical involves:
- exposure assessment leading to the derivation of a predicted environmental concentration (PEC) of a chemical from releases due to its production, processing, use, and disposal. The calculation of a PEC takes into account the dispersion of a chemical into different environmental compartments, elimination and dilution processes, as well as degradation. Monitoring data are also considered.
- effects assessment. Data obtained from acute or long-term toxicity tests are used for extrapolation on environmental conditions. In order to calculate the concentration with expectedly no adverse effect on organisms (Predicted No Effect Concentration, PNEC) the effect values are divided by an assessment factor. This assessment factor depends on the quantity and quality of toxicity data available.
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Jörg Römbke Christa Bauer Annette Marschner 《Environmental science and pollution research international》1996,3(2):78-82
Based on a stepwise (tiered) approach, degradation, adsorption and leaching tests as well as various effect tests (using plants, microorganisms and animals) are recommended for the testing of environmental chemicals. If, after the tests of tiers 1 and 2, the results of a monospecies-effect-test (including a safety factor) are within the range of the predicted exposure, the ecotoxicological hazard should be determined using a terrestrial model ecosystem. Some of the tests for the proposed strategy were selected from practical experience in testing environmental chemicals in the laboratory, and some on the basis of a comprehensive literature review. 相似文献
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A standard screening procedure using sterile soybean and wheat cell suspension cultures has been developed to study the metabolic profiles of established xenobiotics as well as new synthesized compounds. This short term test provides quantitative data on the distribution of metabolites and the parent compound between the nutrient medium and the plant cells, on the amount of more and less polare metabolite fractions in comparison to the parent compound and the amount of substance bound or irreversibly absorbed to the extracted cell fragments. From this data turnover rates are calculated for ranking purpose. Results obtained for 2,4-D, PCP, DEHP and monolinuron as model substances are presented and compared with data from other environmental tests. 相似文献
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S. Marca Schrap Gerard L. G. Sleijpen Willem Seinen Antoon Opperhuizen 《Environmental science and pollution research international》1994,1(2):81-92
This is the second of a two-part series describing the sorption kinetics of hydrophobic organic chemicals. Part I “The Use of First-Order Kinetic Multi-Compartment Models” is published in issue 1 of this journal, pp. 21–28. Sorption kinetics of chlorinated benzenes from a natural lake sediment have been investigated in gas-purge desorption experiments. Biphasic desorption curves, with an initial “fast” part and a subsequent “slow” part, were found for all tested chlorobenzenes. From these results first-order sorption uptake and desorption rate constants were calculated with a two-sediment compartment model, which is presented in the first paper. In three sets of experiments the sorption uptake period and sediment/water ratio were varied. Rate constants are not influenced by these experimental conditions, which supports the partitioning concept for the sorption of hydrophobic organic chemicals in sediments. 相似文献
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Part II: Persistence and Degradability of Organic Chemicals The criteria “Persistence” and “Degradability” are defined and explained, starting from the “functional” definition of the environment. In this definition, theenvironment is the counterpart of thetechnosphere, which consists of all processes controlled by man. A substance is persistent if there are no sinks (degradation processes). It is shown that persistence is the central and most important critérium of environmental hazard assessment of organic chemicals. It follows that all substances released into the environment should be degradable, preferentially into small inorganic molecules (mineralization). As examples for persistent substances, the polychlorinated biphenyls (PCB), the chlorofluorohydrocarbons (CFC), bis (2-ethylhexyl) phthalate (DEHP), and 2,3,7,8-tetrachloro-dibenzo-dioxin (TCDD) are discussed. Finally, an attempt to quantify persistence is made. 相似文献
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Guntram Koller Konrad Hungerbühler Karl Fent 《Environmental science and pollution research international》2000,7(3):135-143
A significant problem for effect assessment of aquatic ecosystems arises from the large ranges of toxicity data, which can be found in different databases and literature. Here, ranges are given for the aquatic toxicity of 27 high production volume chemicals. Based on these illustrative examples and on the current literature on uncertainty in aquatic effect assessment, toxicity ranges are discussed for their possible causes (variation in experimental condition, species, endpoint, time) and ways to handle them (safety factors). Implications and recommendations on the procedure of risk analysis of chemical substances are drawn. Two main requirements for a comprehensive risk assessment are identified, which often play a minor role in current practice (as they are often neglected) as well as in scientific discussion (as they are meant to be trivial). First, data quality must be checked critically before applying any result of a toxicity test. Secondly, experimental data should take into account different species and acute as well as chronic data. If these aspects are considered in risk analysis, which is common practice in ecotoxicology but not always in the context of practical applications in risk engineering, a more comprehensive picture of the environmental toxicity of a chemical substance can be obtained. 相似文献
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José María Navas Helmut Segner 《Environmental science and pollution research international》1998,5(2):75-82
A number of natural and man-made chemicals possess antiestrogenic activity, i.e. they antagonize a broad spectrum of estrogen-induced
responses in vertebrates. Examples of antiestrogens include dioxin, furan and PCB congeners, certain PAHs, pesticides and
indol-3-carbinol derivatives. Major mechanisms of antiestrogenicity are antagonistic action of chemicals at the estrogen receptor,
or binding of chemicals to the arylhydrocarbon (Ah) receptor and subsequent interaction with estrogen-responsive genes. Toxicological
consequences resulting from antiestrogenic activity have not been conclusively demonstrated to date, although antiestrogenic
compounds could critically affect sensitive reproductive and developmental processes. 相似文献
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有毒化学品销毁设施的环境保护 总被引:2,自引:0,他引:2
销毁有毒化学品时最重要的是确保人员安全与健康,以及生态环境安全。因此,其销毁活动必须遵守严格的安全与环保规定。介绍了有毒化学品销毁设施的安全与环境设计标准、控制工艺废弃物,尤其是有毒废气的具体做法,以及销毁设施内部、作业区附近的环境监测方案。这些环境保护措施同样也适用于其他有毒化学品销毁设施。 相似文献
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Repulsion of green sunfish by certain chemicals 总被引:2,自引:0,他引:2