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Toropov AA Toropova AP Benfenati E Gini G Puzyn T Leszczynska D Leszczynski J 《Chemosphere》2012,89(9):1098-1102
Convenient to apply and available on the Internet software CORAL (http://www.insilico.eu/CORAL) has been used to build up quantitative structure-activity relationships (QSAR) for prediction of cytotoxicity of metal oxide nanoparticles to bacteria Escherichia coli (minus logarithm of concentration for 50% effect pEC50). In this study six random splits of the data into the training and test set were examined. It has been shown that the CORAL provides a reliable tool that could be used to build up a QSAR of the pEC50. 相似文献
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Mancini Pamela Bonanno Ferraro Giusy Suffredini Elisabetta Veneri Carolina Iaconelli Marcello Vicenza Teresa La Rosa Giuseppina 《Food and environmental virology》2020,12(1):68-74
Food and Environmental Virology - Salivirus (SalV) is a newly discovered virus associated to acute gastroenteritis in humans. In Italy, its prevalence and genetic diversity is unknown. To reduce... 相似文献
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Svetoslav Slavov Giuseppina Gini Emilio Benfenati 《Journal of environmental science and health. Part. B》2013,48(8):633-637
The pesticides originally designed to kill target organisms are dangerous for many other wild species. Since they are applied directly to the environment, they can easily reach the water basins and the topsoil. A dataset of 125 aromatic pesticides with well-expressed aquatic toxicity towards trout was subjected to quantitative structure activity relationships (QSAR) analysis aimed to establish the relationship between their molecular structure and biological activity. A literature data for LC50 concentration killing 50% of fish was used. In addition to the standard 2D-QSAR analysis, a comparative molecular field analysis (CoMFA) analysis considering the electrostatic and steric properties of the molecules was also performed. The CoMFA analysis helped the recognition of the steric interactions as playing an important role for aquatic toxicity. In addition, the transport properties and the stability of the compounds studied were also identified as important for their biological activity. 相似文献
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Sílvia Bofill-Mas Byron Calgua Pilar Clemente-Casares Giuseppina La Rosa Marcello Iaconelli Michele Muscillo Saskia Rutjes Ana Maria de Roda Husman Andreas Grunert Ingeburg Gräber Marco Verani Annalaura Carducci Miquel Calvo Peter Wyn-Jones Rosina Girones 《Food and environmental virology》2010,2(2):101-109
The presence of human adenoviruses (HAdV) in recreational water might cause disease in the population upon exposure. HAdV detected by PCR could also serve as indicators of the virological water quality. In order to assess the applicability of HAdV to the evaluation of the faecal contamination in European bathing waters, a real-time quantitative PCR assay was used for the quantification of HAdV in 132 samples collected from 24 different recreational marine and freshwater sites in nine European countries. Selected samples presenting positive nested PCR results for HAdV were analyzed using quantitative PCR and 80 samples from a total of 132 produced quantitative results with mean values of 3.2 × 102 per 100 ml of water, being human adenovirus 41 the most prevalent serotype between the samples where adenovirus was typified. HAdV were quantified in samples from all 15 surveillance laboratories. Statistical analysis showed no homogeneous linear relation between HAdV and E. coli, intestinal enterococci or somatic coliphages concentrations in the tested samples when considering all the data together. Significant correlations between HAdV and at least one of the other indicators were observed only when data from individual laboratories were considered. The quantification of HAdV may provide complementary information in relation to the use of bacterial standards in the control of water quality in bathing water. 相似文献
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Conte Marianna Feltracco Matteo Chirizzi Daniela Trabucco Sara Dinoi Adelaide Gregoris Elena Barbaro Elena La Bella Gianfranco Ciccarese Giuseppina Belosi Franco La Salandra Giovanna Gambaro Andrea Contini Daniele 《Environmental science and pollution research international》2022,29(10):13905-13916
Environmental Science and Pollution Research - COVID-19 pandemic raised a debate regarding the role of airborne transmission. Information regarding virus-laden aerosol concentrations is still... 相似文献
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Giovanni Monni MD Rosa M. Ibba Rosalba Laj Cau Giuseppina Mura Silvia Giovanni Olla Antonio Cao 《黑龙江环境通报》1992,12(10):815-820
In this paper we report the fetal loss rate in relation to both maternal and gestational age in 1764 pregnant women who underwent transabdominal chorionic villus sampling (TA-CVS) between January 1986 and August 1990. The fetal loss rate, considered as a proportion of continuing pregnancies, decreased with advancing gestational age at sampling from 4.3 per cent before 9 weeks to 0.4 per cent at or after 13 weeks, the difference being statistically significant (p <0.025). The fetal loss rate increased from 1.6 per cent in women under 30 to 2.4 per cent in women of 40 years or over, but the difference was not statistically significant. Considering that the total fetal loss rate before 28 weeks' gestation was on average 1.91 percent (1.3 per cent under 35 years and 2.8 per cent in women of 35 or over), we believe that TA-CVS is a safe and effective technique for prenatal diagnosis of genetic diseases. 相似文献