Toward harmonizing prospective effectiveness assessment for road safety: Comparing tools in standard test case simulations

Abstract

Objective: With the overall goal to harmonize prospective effectiveness assessment of active safety systems, the specific objective of this study is to identify and evaluate sources of variation in virtual precrash simulations and to suggest topics for harmonization resulting in increased comparability and thus trustworthiness of virtual simulation-based prospective effectiveness assessment.

Methods: A round-robin assessment of the effectiveness of advanced driver assistance systems was performed using an array of state-of-the-art virtual simulation tools on a set of standard test cases. The results were analyzed to examine reasons for deviations in order to identify and assess aspects that need to be harmonized and standardized. Deviations between results calculated by independent engineering teams using their own tools should be minimized if the research question is precisely formulated regarding input data, models, and postprocessing steps.

Results: Two groups of sources of variations were identified; one group (mostly related to the implementation of the system under test) can be eliminated by using a more accurately formulated research question, whereas the other group highlights further harmonization needs because it addresses specific differences in simulation tool setups. Time-to-collision calculations, vehicle dynamics, especially braking behavior, and hit-point position specification were found to be the main sources of variation.

Conclusions: The study identified variations that can arise from the use of different simulation setups in assessment of the effectiveness of active safety systems. The research presented is a first of its kind and provides significant input to the overall goal of harmonization by identifying specific items for standardization. Future activities aim at further specification of methods for prospective assessments of the effectiveness of active safety, which will enhance comparability and trustworthiness in this kind of studies and thus contribute to increased traffic safety.     

Introduced and cryptogenic species in Port Phillip Bay, Victoria, Australia

Port Phillip Bay (PPB) is a large (1,930 km²), temperate embayment in southern Victoria, Australia. Extensive bay-wide surveys of PPB have occurred since 1840. In 1995/1996 the Commonwealth Scientific and Industrial Research Organization (CSIRO) Centre for Research on Introduced Marine Pests (CRIMP) undertook an intensive evaluation of the region with the aims of developing a comprehensive species list of native and introduced biota and contrasting previous bay-wide assessments with a current field survey in order to detect new incursions and discern alterations to native communities. Two methods were used to meet these aims: a re-evaluation of regional museum collections and published research in PPB to identify and determine the timing of introductions; and field surveys for benthic (infauna, epifauna and encrusting) organisms between September 1995 to March 1996. One hundred and sixty introduced (99) and cryptogenic (61) species were identified representing over 13% of the recorded species of PPB. As expected, the majority of these are concentrated around the shipping ports of Geelong and Melbourne. Invasions within PPB appear to be increasing, possibly due to an increase in modern shipping traffic and an increase in aquaculture (historically associated with incidental introductions); however the records of extensive biological surveys suggest that this may, in part, be an artefact of sampling effort. In contrast to Northern Hemisphere studies, PPB (and Southern Hemisphere introductions in general) have significantly different suites of successfully invading taxa. PPB is presented as one of the most invaded marine ecosystems in the Southern Hemisphere.Communicated by M.S. Johnson, Crawley     

Lateral migration and offsite surface emission of landfill gas at City of Montreal Landfill Site

An evaluation of lateral landfill gas migration was carried out at the Saint-Michel Environmental Complex in Montreal, City of Montreal Landfill Site, Canada, between 2003 and 2005. Biogas concentration measurements and gas-pumping tests were conducted in multilevel wells installed in the backfilled overburden beside the landfill site. A migration event recorded in autumn 2004 during the maintenance shutdown of the extraction system was simulated using TOUGH-LGM software. Eleven high-density instantaneous surface monitoring (ISM) surveys of methane were conducted on the test site. Gas fluxes were calculated by geostatistical analyses of ISM data correlated to dynamic flux chamber measurements. Variograms using normal transformed data showed good structure, and kriged estimates were much better than inverse distance weighting, due to highly skewed data. Measurement-based estimates of yearly off-site surface emissions were two orders of magnitude higher than modelled advective lateral methane flux. Nucleodensimeter measurements of the porosity were abnormally high, indicating that the backfill was poorly compacted. Kriged porosity maps correlated well with emission maps and areas with vegetation damage. Pumping tests analysis revealed that vertical permeability was higher than radial permeability. All results suggest that most of the lateral migration and consequent emissions to the atmosphere were due to the existence of preferential flow paths through macropores. In December 2006, two passively vented trenches were constructed on the test site. They were successful in countering lateral migration.     

On climbing trees: an Australian perspective on sustainability and political risk>

This paper examines how political risk taking is necessary for gains in sustainability. It provides a personal perspective covering some of the key turning points in Australia (and some global examples) to demonstrate how policy innovation in sustainability will always require political leaders to go out on a limb and then in hindsight the policy will be seen as obvious and normal. The key components of sustainability (vision, interdisciplinary, geographical and sectoral synergies) are used to illustrate stories of tree climbing. Some deeper levels of sustainability applied to thinking, creativity, belonging and spirituality are then used as the framework for illustrating the significance of political risk taking for sustainability.     

A comparison of different lysis buffers to assess allele dropout from single cells for preimplantation genetic diagnosis

Single cell polymerase chain reaction (PCR) for preimplantation genetic diagnosis (PGD) requires high efficiency and accuracy. Allele dropout (ADO), the random amplification failure of one of the two parental alleles, remains the most significant problem in PCR-based PGD testing since it can result in serious misdiagnosis for compound heterozygous or autosomal dominant conditions. A number of different strategies (including the use of lysis buffers to break down the cell and make the DNA accessible) have been employed to combat ADO with varying degrees of success, yet there is still no consensus among PGD centres over which lysis buffer should be used (ESHRE PGD Consortium, 1999 ). To address this issue, PCR amplification of three genes (CFTR, LAMA3 and PKP1) at different chromosomal loci was investigated. Single lymphocytes from individuals heterozygous for mutations within each of the three genes were collected and lysed in either alkaline lysis buffer (ALB) or proteinase K/SDS lysis buffer (PK). PCR amplification efficiencies were comparable between alkaline lysis and proteinase K lysis for PCR products spanning each of the three mutated loci (ΔF508 in CFTR 90% vs 88%; R650X in LAMA3 82% vs 78%; and Y71X in PKP1 91% vs 87%). While there was no appreciable difference between ADO rates between the two lysis buffers for the LAMA3 PCR product (25% vs 26%), there were significant differences in ADO rates between ALB and PK for the CFTR PCR product (0% vs 23%) and the PKP1 PCR product (8% vs 56%). Based on these results, we are currently using ALB in preference to PK/SDS buffer for the lysis of cells in clinical PGD. Copyright © 2001 John Wiley & Sons, Ltd.     

Greening the Fife Economy: Ecological Modernization as a Pathway for Local Economic Development

Progress in the greening of UK local government has been hampered by uncertainty about the relationship between resource use and environmental protection. Ecological modernizationmay offer the most appropriateparadigm to reconcile economic, social and environmentalinterpretationsof sustainability. The transition from corporate to strategic environmental management currently being attempted by some 'green' authorities can be construed as an attempt to promote ecological modernization in the form of institutional learning. Fife Council in Scotland provides an interesting case study. Progress with corporate environmental management has become bound up with a radical devolution of decision making. Efforts to link the authority's Sustainable Development Policy to a Local Agenda 21 programme have been initiated with the piloting of sustainability indicators.     

Volatiles of the honey bee larva initiate oogenesis in the parasitic mite Varroa destructor

Summary. Varroa reproduction is closely synchronized to the development of its host. In this study we present a new bioassay for field and laboratory tests to evaluate host factors triggering Varroa oogenesis. Female mites deprived of feeding activated oogenesis when perceiving larval volatiles. In laboratory assays the living L5-larva and pentane extracts of the larval cuticle had a clear activating effect. Wax and larval food did not elicit Varroa oogenesis. The activating components apparently are in the polar fraction of the cuticular volatiles. The consequences of this regulative mechanism for the host parasite relationship and prospects for further research are discussed.