Blood transferrin receptor expression in chromosomally abnormal fetuses

In a cross-sectional study of 13 chromosomally abnormal fetuses, umbilical venous blood was obtained by cordocentesis at 17–32 weeks' gestation. Fetal blood transferrin receptor (CD71) expression (mean=79·8 per cent, range=60–98 per cent) and nucleated red cell count (mean=10·4 × 10⁹ per 1, range=1·0–25·0 × 10⁹ per 1) were significantly higher than the appropriate normal mean for gestation (z=3·92, P<0·0001 and z=3·69, P<0·001, respectively). These haematological changes in chromosomally abnormal fetuses would facilitate their prenatal diagnosis by analysis of fetal nucleated red blood cells isolated from the maternal circulation on the basis of CD71 expression.     

Prenatal diagnosis of X-linked retinitis pigmentosa (RP) in five pregnancies at risk

Five pregnancies at risk for X-linked retinitis pigmentosa (RP) have been monitored by first-trimester prenatal diagnosis using DNA markers flanking the RP2 and RP3 loci. Three affected and two unaffected fetuses, including a female carrying a wild-type genotype, were predicted on the basis of marker segregation and estimation of the recombination fraction.     

Evaluation of prenatal diagnosis of limb reduction defects by a registry of congenital anomalies

Prenatal diagnosis performed by ultrasound scan is now a routine part of antenatal care in our region. How many fetal anomalies are actually detected by this procedure? We have used our registry of congenital malformations to answer this question regarding limb reduction defects (LRDs). The mean time of detection of LRDs was 26 weeks of pregnancy (range 16–32 weeks). The sensitivity of prenatal diagnosis of LRDs by ultrasonographic examination was much lower for isolated malformations (fetuses with only one anomaly) than for multiply malformed children with LRDs, 4·0 and 18·2 per cent, respectively. For all cases of LRDs, the percentage of prenatal detection was 11·5. Termination of pregnancy was performed in 6·7 per cent of the cases.     

A new policy‐related measure of population dispersal and sparsity using GIS

Policy indicators applied at a national scale can have considerable financial impact for resource allocations to individual counties, especially if there are extreme local factors. This article develops arid explores a new measure of population dispersal and sparsity and discusses the impact of this indicator in a variety of locations, by using GIS techniques.     

Evaluating regional sustainable development: Approaches,methods and the politics of analysis

One of the by-products of the culture of targets, performance and assessment, is the introduction of uniform methods for the evaluation of the success of policy interventions. Such an approach has been applied to attempts to evaluate regional sustainable development, often with unsatisfactory results. This paper reviews some of the fundamental requirements for the evaluation of regional sustainable development and provides research evidence that indicates the need for procedural and institutional innovation. The evidence in support of innovation reflects the need for assessment procedures and methods to be tailored-to-fit the environmental, social and economic conditions obtaining in an individual region. An additional consideration in analysing the evaluation of regional sustainable development is the extent of socio-political influence over the choice of procedures and methodologies.     

In the aftermath of the Qa'yamat:1 the Kashmir earthquake disaster in northern Pakistan

This article explores the local impact of the catastrophic earthquake in northern Pakistan on 8 October 2005. Drawing on field research, including interviews with 40 earthquake survivors, the post-disaster analysis presented here focuses upon risk awareness and the reactions of respondents to the 7.6 magnitude earthquake that devastated areas of Azad Jammu and Kashmir State, and North-West Frontier Province. The analysis provides insights into local perceptions of seismic hazard and exposure as well as survivors' priorities with regard to rebuilding and reconstruction. The article suggests that the tragedy of the devastating earthquake is entangled in a deeper knot of causal factors that are social, economic and political in nature. Rapid population growth, urbanisation, changing building styles, environmental degradation and lack of preparedness and mitigation are associated with the circumstances that place the population at risk. Remarks concerning present and future risk reduction efforts are included.     

Has the bell tolled for the North American mineral and metal industry?

The author examines the reasons behind the current state of the North American metal mining industry. Taking demand-side factors first, he explains the dramatic fall in metals consumption. External shocks are seen to have affected the previously well rationalized structure of supply in the 1960s, bringing about an increase in production costs and limiting capacity for industrial rationalization. At the beginning of the 1980s, the situation is seen to have been exacerbated by a larger number of producers, more supply sources and an increase in costs. During the course of the decade, the author relates how the situation worsened due to the strength of the US dollar and high interest rates.