PBNA及其同分异构体PANA在小鼠ICR系中致癌性的比较研究

对幼ICR雄性小鼠多次皮下注射PANA或它的同分异构体PANA的二甲基亚砜溶液,总剂量432mg,实验周期在10个月左右时均能引起显著高于对照组动物的恶性肿瘤.PANA诱发小鼠肿瘤可能存在剂量——反应关系.PBNA和PANA诱发肿瘤率相似,均以肺癌为主,但明显有不同的亲器官性.实验结果提示二者的致癌机理可能不是由于形成相应的萘胺所致.PANA对动物有致癌性,在国内外尚未见有报道.     

The macro implications of a complete transformation of U.S. agricultural production to organic farming practices

A national interregional linear programming model of U.S. agriculture is used to evaluate and compare two conventional and three organic production alternatives. The objective is to estimate the effects on production, supply prices, land use, farm income, and export potential, of a complete transformation of U.S. agriculture to organic practices. Crop yields and production costs are estimated for 150 producing regions for seven crops under both conventional and organic methods. Results indicate that compared with conventional methods, widespread organic farming leads to a decrease in total production, lower export potential, higher supply prices, higher value of production, lower costs of production, and higher net farm income. The United States domestic crop demand can be met with organic methods, but would be more expensive. Some interregional shifts in crop production would also occur.     

Teleskope und Detektoren für die Infrarot-Astronomie

Infrared observations with ground-based and balloon-borne telescopes are hampered by thermal background radiation and absorption caused by the earth's atmosphere. A sensitivity gain of up to three orders of magnitude can be obtained under the low photon background conditions of a helium-cooled space telescope. Physical properties of photodetectors and bolometers as well as their application to the new infrared telescopes aboard satellites and Spacelab are discussed.     

Amniotic fluid alpha-fetoprotein levels and prenatal diagnosis of autosomal trisomies

Pregnancies with fetal trisomy 21 have been associated with low amniotic fluid alpha-fetoprotein levels (AFAFP). This observation led to the suggestion that low AFAFP levels be used as a criterion for completion of a chromosomal analysis in patients who are not otherwise at increased risk for a fetal chromosome abnormality and in whom karyotyping might not have been completed for economic reasons. In order to assess the usefulness of such criteria, we reviewed the AFAFP levels of 90 cases of fetal trisomy 21, 23 cases of trisomy 18, and 10 cases of trisomy 13. These were compared with 2400 control samples with normal chromosome constitution. AFAFP levels were generally lower in pregnancies with trisomy 21, showing a median value of 0·72 MoM. However, 40 per cent of the trisomy 21 samples had AFAFP values greater than 0·8 MoM and 20 per cent were over 1·0 MoM. These data imply that over 50 per cent of Down syndrome cases might have been missed using a cut-off level of 0·70 MoM for completion of chromosome analysis. Using a higher cut-off level will leave only a small percentage of samples unkaryotyped. The distribution of AFP levels in trisomy 13 and 18 is no different from controls; we therefore believe that fetal karyotyping should be completed in every amniotic fluid sample obtained.