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381.
Linda?Anderson-BerryEmail author David?King 《Mitigation and Adaptation Strategies for Global Change》2005,10(3):367-392
Community mitigation of hazard impact requires hazard knowledge and preparedness on the part of the members of diverse and
complex communities. Longitudinal research in the tropical cyclone prone north of Australia has gathered extensive datasets
on community awareness, preparedness and knowledge, in order to contribute to education campaigns and mitigation strategies.
Data have been used to identify issues of vulnerability to cyclones and capacity to deal with the hazard. This has been developed
as a community vulnerability and capacity model that may be applied to diverse communities in order to assess levels of capability
to mitigate and deal with the cyclone hazard. The model is presented here in a simplified form as its development is evolving
and ongoing. 相似文献
382.
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384.
Eleni Costa Christopher Thrasivoulou David L. Becker Jan A. Deprest Anna L. David Tina T. Chowdhury 《黑龙江环境通报》2023,43(10):1284-1295
Objective
The effects of mechanical stimulation in preterm amniotic membrane (AM) defects were explored.Methods
Preterm AM was collected from women undergoing planned preterm caesarean section (CS) due to fetal growth restriction or emergency CS after spontaneous preterm prelabour rupture of the membranes (sPPROM). AM explants near the cervix or placenta were subjected to trauma and/or mechanical stimulation with the Cx43 antisense. Markers for nuclear morphology (DAPI), myofibroblasts (αSMA), migration (Cx43), inflammation (PGE2) and repair (collagen, elastin and transforming growth factor β [TGFβ1]) were examined by confocal microscopy, second harmonic generation, qPCR and biochemical assays.Results
In preterm AM defects, myofibroblast nuclei were highly deformed and contractile and expressed αSMA and Cx43. Mechanical stimulation increased collagen fibre polarisation and the effects on matrix markers were dependent on tissue region, disease state, gestational age and the number of fetuses. PGE2 levels were broadly similar but reduced after co-treatment with Cx43 antisense in late sPPROM AM defects. TGFβ1 and Cx43 gene expression were significantly increased after trauma and mechanical stimulation but this response dependent on gestational age.Conclusion
Mechanical stimulation affects Cx43 signalling and cell/collagen mechanics in preterm AM defects. Establishing how Cx43 regulates mechanosignalling could be an approach to repair tissue integrity after trauma. 相似文献385.
386.
387.
Rosalind Aughwane Emma Ingram Edward D. Johnstone Laurent J. Salomon Anna L. David Andrew Melbourne 《黑龙江环境通报》2020,40(1):38-48
Objective
Magnetic resonance imaging (MRI) of placental invasion has been part of clinical practice for many years. The possibility of being better able to assess placental vascularization and function using MRI has multiple potential applications. This review summarises up-to-date research on placental function using different MRI modalities.Method
We discuss how combinations of these MRI techniques have much to contribute to fetal conditions amenable for therapy such as singletons at high risk for fetal growth restriction (FGR) and monochorionic twin pregnancies for planning surgery and counselling for selective growth restriction and transfusion conditions.Results
The whole placenta can easily be visualized on MRI, with a clear boundary against the amniotic fluid, and a less clear placental-uterine boundary. Contrasts such as diffusion weighted imaging, relaxometry, blood oxygenation level dependent MRI and flow and metabolite measurement by dynamic contrast enhanced MRI, arterial spin labeling, or spectroscopic techniques are contributing to our wider understanding of placental function.Conclusion
The future of placental MRI is exciting, with the increasing availability of multiple contrasts and new models that will boost the capability of MRI to measure oxygen saturation and placental exchange, enabling examination of placental function in complicated pregnancies. 相似文献388.
Laura Y. Sifuentes Sonia L. M. Fankem Kelly Reynolds Akrum H. Tamimi Charles P. Gerba David Koenig 《Food and environmental virology》2017,9(1):14-19
The purpose of this study was to validate the use of adenosine triphosphate (ATP) for evaluating hygiene intervention effectiveness in reducing viral dissemination in an office environment. The bacterial virus MS-2 was used to evaluate two scenarios, one where the hand of an individual was contaminated and another where a fomite was contaminated. MS-2 was selected as a model because its shape and size are similar to many human pathogenic viruses. Two separate experiments were conducted, one in which the entrance door push plate was inoculated and the other in which the hand of one selected employee was inoculated. In both scenarios, 54 selected surfaces in the office were tested to assess the dissemination of the virus within the office. Associated surface contamination was also measured employing an ATP meter. More than half of the tested hands and surfaces in the office were contaminated with MS-2 within 4 h. Next, an intervention was conducted, and each scenario was repeated. Half of the participating employees were provided hand sanitizer, facial tissues, and disinfecting wipes, and were instructed in their use. A significant (p < 0.05) reduction was observed in the number of surfaces contaminated with virus. This reduction in viral spread was evident from the results of both viral culture and the surface ATP measurements, although there was no direct correlation between ATP measurements with respect to viral concentration. Although ATP does not measure viruses, these results demonstrate that ATP measurements could be useful for evaluating the effectiveness of hygiene interventions aimed at preventing viral spread in the workplace. 相似文献
389.
David F. Staples Mark L. Taper Brian Dennis Robert J. Boik 《Environmental and Ecological Statistics》2009,16(4):547-560
Estimates of a population’s growth rate and process variance from time-series data are often used to calculate risk metrics
such as the probability of quasi-extinction, but temporal correlations in the data from sampling error, intrinsic population
factors, or environmental conditions can bias process variance estimators and detrimentally affect risk predictions. It has
been claimed (McNamara and Harding, Ecol Lett 7:16–20, 2004) that estimates of the long-term variance that incorporate observed
temporal correlations in population growth are unaffected by sampling error; however, no estimation procedures were proposed
for time-series data. We develop a suite of such long-term variance estimators, and use simulated data with temporally autocorrelated
population growth and sampling error to evaluate their performance. In some cases, we get nearly unbiased long-term variance
estimates despite ignoring sampling error, but the utility of these estimators is questionable because of large estimation
uncertainty and difficulties in estimating correlation structure in practice. Process variance estimators that ignored temporal
correlations generally gave more precise estimates of the variability in population growth and of the probability of quasi-extinction.
We also found that the estimation of probability of quasi-extinction was greatly improved when quasi-extinction thresholds
were set relatively close to population levels. Because of precision concerns, we recommend using simple models for risk estimates
despite potential biases, and limiting inference to quantifying relative risk; e.g., changes in risk over time for a single
population or comparative risk among populations. 相似文献