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181.
Verónica Bastos José M.P. Ferreira-de-Oliveir Joana Carrol Ana L. Daniel-da-Silv Iola F. Duarte Conceição Santos Helena Oliveira 《环境科学学报(英文版)》2017,29(1):191-201
The antibacterial potential of silver nanoparticles(AgNPs) resulted in their increasing incorporation into consumer,industrial and biomedical products.Therefore,human and environmental exposure to AgNPs(either as an engineered product or a contaminant)supports the emergent research on the features conferring them different toxicity profiles.In this study,30 ran AgNPs coated with citrate or poly(ethylene glycol)(PEG) were used to assess the influence of coating on the effects produced on a human hepatoma cell line(HepG2),namely in terms of viability,apoptosis,apoptotic related genes,cell cycle and cyclins gene expression.Both types of coated AgNPs decreased cell proliferation and viability with a similar toxicity profile.At the concentrations used(11 and 5 μg/mL corresponding to IC50 and-IC10 levels,respectively) the amount of cells undergoing apoptosis was not significant and the apoptotic related genes BCL2(anti-apoptotic gene)and BAX(pro-apoptotic gene) were both downregulated.Moreover,both AgNPs affected HepG2 cell cycle progression at the higher concentration(11 μg/mL) by increasing the percentage of cells in S(synthesis phase) and G2(Gap 2 phase) phases.Considering the cell-cycle related genes,the expression of cyclin B1 and cyclin E1 genes were decreased.Thus,this work has shown that citrate- and PEG-coated AgNPs impact on HepG2 apoptotic gene expression,cell cycle dynamics and cyclin regulation in a similar way.More research is needed to determine the properties that confer AgNPs at lower toxicity,since their use has proved helpful in several industrial and biomedical contexts. 相似文献
182.
Dall’Agnol Patricia Libardi Nelson da Silva Eduarda Coradini da Costa Rejane Helena Ribeiro 《Journal of Polymers and the Environment》2022,30(2):695-706
Journal of Polymers and the Environment - The purpose of this study was to investigate the phosphorus (P) adsorption mechanism, kinetic, isothermal and thermodynamic parameters using alginate-like... 相似文献
183.
Virginia Alves Martins Maria Cazelli Lucas Yhasnara Missilene da CristineSilva Layla Barros Saibro Murilo Bobco Fabia Emanuela Rafaloski Rubio Belen Ferreira Bruna Castelo Wellen Fernanda Louzada Santos José Francisco Ribeiro Sara Frontalini Fabrizio Martínez-Colón Michael Pereira Egberto Antonioli Luzia Geraldes Mauro Rocha Fernando Sousa Silvia Helena Mello e Manuel Alveirinho Dias João 《Environmental science and pollution research international》2022,29(46):69652-69679
Environmental Science and Pollution Research - We analyze potential Late Holocene metal contamination along a sediment core collected in the distal zone of Ria de Vigo (North Spain). Statistical... 相似文献
184.
Individuals’ food choices are intimately connected to their self-images and world views. Some dietary choices adopted by consumers
pose restrictions on their use of genetically modified food (GMF). It is quite generally agreed that some kind of labeling
is necessary for respecting consumers’ autonomy of choice regarding GMF. In this paper, we ask whether the current practice of mandatory
labeling of GMF products in the European Union is a sufficient administrative procedure for respecting consumers’ autonomy. Three issues concerning this question are discussed. First,
we argue that labeling needs to be accompanied by relevant and understandable information on genetic modification, genetically
modified food, and the European practice of GMF labeling. Second, we claim that this type of informing makes it less likely
that consumers start to avoid GMF products just because labels make them suspicious of the products. It is further noted that
even though some consumers may react to labels this way, labels do not restrict their autonomy of choice. Third, a need for
more precise labels indicating the source of the transferred gene is considered. It is found out that such labels are not
morally necessary when also non-GMF products are available and no relevant differences (such as differences in price and healthiness)
exist between them and GMF products. However, in some other cases more precise labels may be needed for respecting consumers’
autonomy of choice. 相似文献
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Izonete Cristina Guiloski Stéfani Cibele Rossi Cesar Aparecido da Silva Helena Cristina Silva de Assis 《Journal of environmental science and health. Part. B》2013,48(4):272-277
This study was undertaken to investigate the effects of sublethal concentration of three different classes of insecticides (carbamate, organophosphate, and pyrethroid compounds) on the freshwater fish Corydoras paleatus. For this purpose, fish were exposed for 96 hours to commercial pesticides. Different biomarkers were analyzed as levels of lipid peroxidation (LPO), piscine micronucleus test, and enzymatic activities of catalase (CAT), glutathione S-transferase (GST), and acetylcholinesterase (AChE). The brain AChE was inhibited with carbaryl and methyl parathion, but no inhibition was observed with deltamethrin. The insecticides did not cause oxidative stress or genotoxic effects at the tested concentrations. Further studies are needed to elucidate the biotransformation of Corydoras paleatus insecticides and a possible resistance mechanism. 相似文献
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In many countries over the last decades, state initiatives have emerged to promote and support public participation in policy-making. Despite the emphasis on participation and deliberation, there are groups that remain outside the participatory proceedings. We follow through two case studies from Finland on how active citizen groups became excluded in the policy processes but decided to act nevertheless. Conceptually, the article tells two stories about multi-signification and improvisation in nature conservation processes from the citizen participation point of view. Using practice-oriented policy analysis, we explore the actors' conflicting interpretations of acting for “the sake of the lake”. We argue that in these kinds of complex policy processes, improvisation should be given more space. 相似文献