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Council Regulation (EEC) No 2455/92 has been adopted by the Council of the European Communities, in 1992, to improve information exchange on certain dangerous chemicals with third countries, particularly developing countries. To implement the notification procedure in accordance with the Regulation, a database has been developed to manage and simplify the procedure. The software exists in three versions; one adapted for use by the Designated Authorities of the Member States, another for the European Chemicals Bureau (ECB) and the third one is an information version aimed at Designated National Authorities outside the European Union and Industry. The database “EDEXIM” is currently working in a PC environment and is being developed as an on-line system with a stand-alone client/server architecture.  相似文献   
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A seasonal study of arsenic in groundwater,Snohomish County,Washington, USA   总被引:2,自引:0,他引:2  
A series of arsenic poisonings near Granite Falls in Snohomish County, Washington, were identified during 1985–87. An initial investigation revealed the source of arsenic exposure to be high levels of arsenic in well water. A large number of wells in eastern Snohomish County were tested, residents were interviewed and sources of contamination, both natural and man-made, were investigated. More than 70 private drinking-water wells were found to contain elevated levels of arsenic . One well contained 33 mg As L–1. The finding of elevated arsenic levels in a previously approved drinking-water well for a restaurant, plus suggestions of symptoms consistent with arsenic poisoning among people with wells with no detectable arsenic, raised concern over possible temporal variation in arsenic levels. To evaluate this temporal variation, a 12-month study of arsenic in groundwater was conducted in selected wells near Granite Falls. The 12-month study of 26 wells, conducted between February 1988 and January 1989, found arsenic levels for individual wells to vary from one to 19 fold over time. Because of this variability, four out of the eight wells with arsenic levels close to the Maximum Contamination Level (MCL) of 0.050 mg As L–1 would have been considered safe on the basis of a single sample, but would have exceeded the MCL at another time of the year.In areas with a high occurrence of arsenic contaminated drinking water, approval of well water prior to the sale of a house or issuance of a building permit which is based on a single arsenic test may result in later findings of unacceptable drinking water. When the arsenic is near the MCL, it may be prudent to follow well-water arsenic concentrations over time to assure that the arsenic level remains within acceptable bounds. If lower arsenic standards are adopted for drinking water, the issue of temporal variation around the standard will become a matter of more widespread concern.To whom correspondence should be addressed. The contents of this paper do not necessarily reflect the views and policies of the US Environmental Protection Agency.  相似文献   
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Problem and Objective

The number of older drivers who might benefit from driver retraining is growing. A previous review on the effectiveness of older driver retraining included intervention studies up to 2004. The objective was to perform an updated systematic review of the effectiveness of older driver retraining for improving driving-related skills and reducing crash rates.

Method

Articles published from 2004-2008 were grouped according to the intervention provided and outcome studied. Randomized clinical trials (RCTs) were appraised using the Physiotherapy Evidence Database (PEDro) Scale and scored for quality according to their internal validity. Each intervention's effectiveness was then rated and assigned a level of evidence by combining pre- and post- 2004 findings.

Results

Three RCTs and one matched-pairs cohort design met the inclusion criteria. There is strong evidence (Level 1a) that education combined with on-road training improves driving performance and moderate evidence (Level 1b) that it improves knowledge. There is moderate evidence (Level 1b) that physical retraining improves driving performance. There is moderate evidence (Level 1b) that an educational intervention curriculum alone is not effective in reducing crashes.

Summary

The updated evidence on the effectiveness of retraining aimed at older drivers is sufficiently encouraging to merit assertive health promotion actions regarding intervention and program planning.

Impact on Industry

These positive findings warrant a comprehensive plan that has both behavioral and monetary incentives encouraging older driver participation in programs aimed at driver safety.  相似文献   
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Population trends from the Breeding Bird Survey are widely used to focus conservation efforts on species thought to be in decline and to test preliminary hypotheses regarding the causes of these declines. A number of statistical methods have been used to estimate population trends, but there is no consensus as to which is the most reliable. We quantified differences in trend estimates or different analysis methods applied to the same subset of Breeding Bird Survey data. We estimated trends for 115 species in British Columbia using three analysis methods: U.S. National Biological Service route regression, Canadian Wildlife Service route regression, and nonparametric rank-trends analysis. Overall, the number of species estimated to be declining was similar among the three methods, but the number of statistically significant declines was not similar (15, 8, and 29 respectively). In addition, many differences existed among methods in the trend estimates assigned to individual species. Comparing the two route regression methods, Canadian Wildlife Service estimates had a greater absolute magnitude on average than those of the U.S. National Biological Service method. U.S. National Biological Service estimates were on average more positive than the Canadian Wildlife Service estimates when the respective agency's data selection criteria were applied separately. These results imply that our ability to detect population declines and to prioritize species of conservation concern depend strongly upon the analysis method used. This highlights the need for further research to determine how best to accurately estimate trends from the data. We suggest a method for evaluating the performance of the analysis methods by using simulated Breeding Bird Survey data.  相似文献   
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