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Gene expression experiments were targeted in order to monitor the ABC efflux transporters, which is potentially involved in cellular detoxification/defense. Changes in expression levels of different ABC genes in kidney of Oncorhynchus mykiss fed with melamine and melamine + cyanuric acid enriched diets were recorded in both treated groups by mRNA ΔΔCT relative quantification method. Expression profiles of eight different ABC genes basically showed low alterations in melamine group and more consistent changes in melamine + cyanuric acid treated fish, compared with own control. In the last group ABCC2 gene over expression was the more evident alteration. These results suggest that ABC efflux system could be involved in mobilization of hydrophilic molecules in the forcing condition of chronic exposure.  相似文献   
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The mercury content has been determined in samples of fumarolic gases, phreatic waters, soil and vegetation collected at Vulcano, Aeolian Islands, Italy. Volcanic activity is demonstrated as a source of natural mercury pollution whose extent has been evaluated here by studying the contribution of different components of the surface environment. The possible influences for living organisms are examined.  相似文献   
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We describe two independent cases of Brachmann-de Lange syndrome (BDLS) in which second trimester fetal sonographic studies showed the presence of a diaphragmatic hernia and upper limb anomalies. In both cases the karyotypes were normal. Intrauterine growth restriction (IUGR) developed in the third trimester. Postnatal and postmortem physical examinations demonstrated typical physical findings associated with BDLS. The prenatal diagnosis of diaphragmatic hernia with associated anomalies should prompt consideration of an underlying genetic etiology. Copyright © 2002 John Wiley & Sons, Ltd.  相似文献   
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In Europe, biodiversity conservation relies on the Natura 2000 network. However, it is often difficult to ensure the favourable conservation status of species and habitats due to scarce financial resources. Therefore, we examined the current management strategies and conditions of three Italian Natura 2000 sites based on a questionnaire and stakeholder meetings. Additionally, we qualitatively assessed the potential of ecosystem services provision. Then an A'WOT analysis was carried out to identify and highlight internal and external factors affecting natural and semi-natural ecosystems and the socio-economic context, aiming to propose new instruments and approaches for effective management. The analysis revealed opportunities for developing tourism and the high potential of regulating services, whereas the bureaucratic burden and a lack of funding threaten the attainment of biodiversity conservation goals. Thus, we propose that payments for ecosystem services should be considered to support the effective management of Natura 2000 sites.  相似文献   
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