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61.
The aim of present study was to validate hepatoprotective and antioxidant activities of the bark of Bridelia retusa. The aqueous ethanol extract of B. retusa exhibited highest in vitro hepatoprotective effects as evident from the significantly reduced serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) into the incubation medium of rat hepatocytes with carbon tetrachloride (CCl4), over the other organic extracts (chloroform, ethylacetate, and methanol). CCl4 administered through subcutaneous injection produced a marked elevation in the serum levels of GOT, GPT, lactate dehydrogenase, alkaline phosphatase, bilirubin, thiobarbituric acid reactive substances, and decreased in the levels of reduced glutathione, superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase, glutathione peroxidase, and total protein content. The biochemical activities were normalized in the pretreatment of rats induced by CCl4 with different doses (250 and 500 mg kg?1) of the aqueous ethanol extract of B. retusa. Histopathological changes induced by CCl4 were also significantly attenuated by aqueous ethanol extract of B. retusa treatment. The activity of the aqueous ethanol extract of B. retusa at the dose of 500 mg kg?1 was comparable to the standard drug, silymarin (25 mg kg?1). The overall data indicated that B. retusa possesses a potent protective effect against CCl4-induced hepatic damage and oxidative stress. 相似文献
62.
Chinnasamy Rajaram Prakash Theivendran Panneerselvam Sundararajan Raja 《毒物与环境化学》2013,95(8):1397-1407
In the present study, a series of novel Schiff bases of isatin were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by reaction of isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, 13C-NMR, mass spectroscopy, and elemental analysis. These compounds were screened for antioxidant activity by DPPH, nitric oxide and hydrogen peroxide radical scavenging activity. In all the methods, the compound 3-(4-(3,4,5-trimethoxy benzylideneamino)phenylimino) indoline-2-one (5d) showed highest antioxidant activity because of the presence of electron donating groups and the compound 3-(4-(4-nitrobenzylideneamino)phenylimino) indoline-2-one (5f) showed the least activity because of the presence of an electron withdrawing group. 相似文献
63.
Khan Faizal Krishnaraj Srinivasamoorthy Raja Prakash Selvaraj Gopinath Cheelil Rabina 《Environmental science and pollution research international》2021,28(15):18567-18588
Environmental Science and Pollution Research - The present study area falls beside the coastal zone of Tamil Nadu, and Puducherry is characterized by varied geological formations that mostly... 相似文献
64.
Muthusamy Parimala Devi Velusamy Gowrishankar Thandavan Sathya Govindasamy Boopathi Raja Savarimuthu Nithya 《Environmental science and pollution research international》2022,29(24):35542-35556
Environmental Science and Pollution Research - Nowadays, modern industries generate their energy by using renewable solar. The rapid increase in photovoltaic (PV) module installations provides a... 相似文献
65.
Environmental Modeling & Assessment - The objective of this paper is to evaluate the indirect impacts of a set-aside policy on the environment through crop intensification. We estimate a... 相似文献