Cancer cluster among police detachment personnel

An apparent cancer cluster at a police detachment in a coastal British Columbia community was investigated. Police personnel suspected that the detachment building may have been a factor. Police personnel (20 current and 154 previous employees) associated with the detachment since 1963, the date of occupancy, were traced. After all 174 cases were contacted directly, or next of kin in case of death, a total of 16 cases of cancer or suspected cancers were reported. Of these 16, eight cases of cancer were confirmed through a cancer registry. Cancers included testicular, cervical, colon, skin (including melanoma), leukemias and lymphomas with an age range of diagnosis between 22 and 44 years. There was no evidence for an underlying event, factor or condition in the police building that could be attributed to the observed cancer cases. A possible association between these cancers and the use of police traffic radar is discussed.     

A risk assessment of chlorinated aliphatics in bioremediated soils

Natural microbes living in contaminated subsurface media can be enhanced to degrade large concentrations of contaminating compounds at a faster rate than the microbes could degrade under natural conditions. A feasibility study demonstrating this principle was performed on-site in southern Louisiana to evaluate the effectiveness of two microbial degradation remediation methods used to decrease the human carcinogenic risks associated with exposure to ethylene dichloride and vinyl chloride concentrations in contaminated clay and sludge soils at the site. The results of the study are compared to an acceptable Louisiana Department of Environmental Quality closure level to evaluate in-situ microbial enhancement in chlorinated aliphatic-contaminated sludge and clay soils as a remediation/cleanup alternative in similar industrial situations.     

The town scheme approach to urban conservation in England and Scotland

The Town Scheme approach to urban conservation is being used increasingly as a major method of repairing historic buildings in conservation areas. A Town Scheme involves a long‐term financial and administrative partnership between the various levels of government. An annual budget made up of equal contributions from central government and the participating local authority is used to finance a multi‐year programme of repairs. Owners can apply for grants which are usually for 40 per cent of approved costs, and repair work must relate to the original structure and architectural details of an approved list of historic buildings. Town Schemes by themselves cannot totally transform the environmental quality of conservation areas, and the most successful schemes are part of wide‐ranging renewal and enhancement projects.     

CAGED FISH AS MONITORS OF POLLUTION: EFFECTS OF CHLORINATED EFFLUENT FROM A WASTEWATER TREATMENT PLANT1

ABSTRACT: Fish confined to cages were used to determine the effects of effluent from a wastewater treatment plant (WWTP). Control fish were kept in cages in an aquaculture pond. Acute effects of the effluent entering the final oxidation pond of the WWTP were determined by confining channel catfish (Ictalurus punctatus) at the pond inlet; the mean total residual chlorine (TRC) concentration was 0.9 mg/l during this exposure. After 8 h, 42 percent of the fish had died and survivors had severe lesions of the skin and gills. During the first two weeks of exposure, channel catfish at the outlet of the final oxidation pond (mean TRC=0.1 mg/l) were predisposed to bacterial infection but lost the parasitic trematodes that were on the gills when the fish were placed in cages. After several weeks, exposed fish had histologic lesions, enlarged livers, and reduced growth. The presence of unidentified carcinogen(s) in the effluent of this WWTP was indicated by papillomas developing on caged black bullheads (Ictalurus melas) and hepatic-enzyme induction in channel catfish. In situ exposure of caged fish was advantageous because storage and pretreatment of water samples were not required, and exposure levels corresponded to those present in the environment. The use of cages for containment of fish during field exposure allowed confinement to the location of interest and convenient sampling of the fish. Unlike wild fish, the caged fish could be compared to control fish with the same pre-exposure history.     

Assessing and evaluating environmental impacts at proposed nuclear power plant sites

The applicability of decision analysis for assessing, evaluating, and reporting possible environmental impacts of proposed large-scale projects is illustrated. A study concerning the ecological impacts of constructing and operating nuclear power facilities in the Pacific Northwest is used as an example. Possible impacts are quantified for two objectives: minimizing adverse impacts on salmonids and minimizing biological disturbance. The results provide information about both the direct and indirect consequences of the impact. This approach explicitly addresses the multiple objective and uncertainty issues inherent in environmental problems. It also provides a mechanism for illuminating the value structure which is utilized in the evaluation process.     

The lag daemon: hysteresis in rebuilding landscapes and implications for biodiversity futures

Many native bird species in production landscapes of south-eastern Australia demonstrably are declining, with loss of native vegetation as the major cause. Our biodiversity management objectives must be to increase the probabilities of persistence of birds that should occur in the landscape. To do so, there needs to be extensive amounts of new plantings. However, one must be conscious that: (1) new plantings in the impoverished soils and increasing aridity of southern Australia will take many decades to mature, and, also, will offer suitable habitats for a sequence of different species over the course of that maturation process; and (2) much existing vegetation is senescent or will be in a few decades' time. Recent landscape rebuilding models do not explicitly consider maturation time-lags. These hystereses in habitat maturation may create 'bottlenecks' at future times (e.g. in 50yr) that might prevent some species from persisting in whole landscapes even though such landscapes may be much more suitable in 100yr than now. There are several critical issues: (1) species differ in habitat needs and even one species may require different kinds of habitats for foraging and for breeding; (2) landscapes must be conceived, and managed, as spatial and temporal mosaics to allow for persistence of the full set of species that should occupy them, meaning that senescing and replanted habitats may need to be juxtaposed; and (3) in certain particularly problematic landscapes, some highly productive agricultural lands may need to be used for providing habitat because maturation can be fast-tracked in fertile, well-watered locations. The problem is a complex one of scheduling and placement, and its optimization presents major theoretical and analytical challenges.     

Estrogenicity profile and estrogenic compounds determined in river sediments by chemical analysis, ELISA and yeast assays

An effects-directed strategy was applied to bed sediments of a polluted tributary in order to isolate and identify the major estrogenic chemicals it discharges into the River Po, the principal Italian watercourse. Sediment extract was concentrated by solid phase extraction and then fractioned into 10 fractions by reversed phase high performance liquid chromatography (RP-HPLC). Estrogenic activity of whole extract and fractions were determined using a recombinant yeast assay containing the human estrogen receptor (YES). The 10 fractions and whole extract were analysed for target compounds, e.g. estrone (E1), 17beta-estradiol (E2), estriol (E3), 4-nonylphenol (NP), 4-tert-octylphenol (t-OP), bisphenol A (BPA), using both liquid chromatography-tandem mass spectrometry (LC-MS/MS) and non-competitive enzyme-linked immunosorbent assays (ELISA). The YES assay determined high estrogenic activity in whole sediment (15.6 ng/g EE2 equivalents), and positive results for fractions nr 1, 2, 6, 7 and 8. E1, E3 and NP were the main estrogenic chemicals, however, other unidentified compounds contributed to sediment estrogenicity, particularly for polar fractions nr 1 and 2. A GC-MS screening performed in scan mode identified other potential contributors such as phthalates (DBP, BBP), and OP isomers. A next sampling campaign extended to other tributaries and receiving stretches of the River Po confirmed E1, E3 and NP as major estrogenic chemicals potentially threatening other sites of the main river. In general, target compound ELISAs have been shown to be suitable tools for a rapid screening of wide areas or large numbers of environmental samples for estrogenic risk. The potential for interferences suggests however to use cautiously the concentration values obtained from some of the immunoassays.     

Role of dissolved humic acids in the biodegradation of a single isomer of nonylphenol by Sphingomonas sp

This study shows the important role of humic acids in the degradation of ¹⁴C and ¹³C labeled isomer of NP by Sphingomonas sp. strain TTNP3 and the detoxification of the resulting metabolites. Due to the association of NP with humic acids, its solubility in the medium was enhanced and the extent of mineralization of nonylphenol increased from 20% to above 35%. This was accompanied by the formation of significant amounts of NP residues bound to the humic acids, which also occurred via abiotic reactions of the major NP metabolite hydroquinone with the humic acids. Gel permeation chromatography showed a non-homogenous distribution of NP residues with humic acids molecules, with preference towards molecules with high-molecular-weight. Solid state ¹³C nuclear magnetic resonance spectroscopy indicated that the nonextractable residues resulted exclusively from the metabolites. The chemical shifts of the labeled carbon indicated the possible covalent binding of hydroquinone to the humic acids via ester and possibly ether bonds, and the incorporation of degradation products of hydroquinone into the humic acids. This study provided evidences for the mediatory role of humic acids in the fate of NP as a sink for bacterial degradation intermediates of this compound.     

Evaluation of soil-erosion and pesticide-exposure control strategies

A linear-programming model of agriculture in the Chowan-Pasquotank river basin of North Carolina is used to analyze soil-erosion reduction strategies while holding pesticide loadings constant. Two forms of pesticide-exposure indexes, reflecting terrestrial and aquatic exposure, are used to aggregate the effects of pesticide applications for no-till and conventional till systems. Reductions in pesticide exposure are compatible with high levels of erosion control. Greater reductions of pesticide exposure with comparable levels of erosion control are achievable at relatively low cost. Such reductions imply shifts in cropping patterns and resource use, however.     

Underage drinking: frequency, consequences, and interventions

OBJECTIVES: To examine the frequency of underage drinking, driving after drinking and alcohol-related crashes, trends in these behaviors, and promising interventions. METHODS: We examined drinking and drinking- and-driving behaviors reported in the United States in the 2001 U.S. National Household Survey of Drug Abuse, the Centers for Disease Control and Prevention 2001 Youth Risk Behavior Survey, the 1992 National Longitudinal Alcohol Epidemiologic Study, and the 1999 National Survey of Drinking and Driving conducted for the National Highway Traffic Administration. We also examined the 1999 European School Survey Project on Alcohol and Other Drugs. Alcohol-related fatal crashes were examined from the U.S. Fatality Analysis Reporting System. Evaluation of interventions to reduce teenage drinking and driving after drinking were reviewed. RESULTS: In the United States, 19% of youth ages 12-20 consumed five or more drinks on an occasion in the past 30 days. Although European nations have lower legal drinking ages (16-18) than in the United States (21), similar proportions engage in underage drinking. In two-thirds of European countries, a greater percentage of 15-16 year-olds drank five or more drinks on an occasion in the past month than in the United States. In both the United States and Europe, the earlier people begin to drink, the greater the likelihood of developing alcohol dependence and other alcohol-related problems, including alcohol-related crash involvement, during adolescence and adult years. During the past 20 years alcohol-related traffic deaths among people younger than 21 have been cut in half in the United States, but progress has halted since 1995 and the problem is still large. Interventions shown by research to reduce alcohol-related crashes among youth include raising the legal drinking age to 21, zero tolerance laws, and some interventions that are family, school, or community based. CONCLUSIONS: Despite research showing that a variety of interventions can reduce underage drinking and alcohol-related crash fatalities, the frequency of these behaviors remains high and the average age of drinking initiation is declining in the United States. Efforts are needed to enhance publicized enforcement of underage drinking laws. Comprehensive community interventions that include enforcement of these laws also are needed.