Prenatal assessment and management of sacrococcygeal teratoma

Sacrococcygeal teratoma (SCT) is one of the most common tumors in newborns with a birth prevalence of up to 1 in 21 700 births. Routine fetal anomaly screening programs allow for prenatal diagnosis in many cases. Fetal ultrasound with Doppler evaluation and more recently magnetic resonance imaging may be used to document the extent of the tumor as well as identifying the population at risk for serious fetal complications. Rapidly growing SCT and highly vascularized tumors are more likely to have hemodynamic repercussions. Fetal hydrops is usually considered as a poor prognostic marker and a potential indicator for fetal intervention. Newborns with SCT require stabilization prior to early surgical resection. In case of malignancy additional chemotherapy may be required. SCT may result in significant morbidity, either directly or as a consequence of surgical therapy. Careful postnatal follow-up is required for timely identification and treatment of complications as well as recurrence. This paper aims to review the perinatal management of this condition. Copyright © 2011 John Wiley & Sons, Ltd.     

Reviewing the relevance of dioxin and PCB sources for food from animal origin and the need for their inventory,control and management

Background

In the past, cases of PCDD/F and PCB contamination exceeding limits in food from animal origin (eggs, meat or milk) were mainly caused by industrially produced feed. But in the last decade, exceedances of EU limit values were discovered more frequently for PCDD/Fs or dioxin-like(dl)-PCBs from free range chicken, sheep, and beef, often in the absence of any known contamination source.

Results

The German Environment Agency initiated a project to elucidate the entry of PCBs and PCDD/Fs in food related to environmental contamination. This paper summarizes the most important findings. Food products from farm animals sensitive to dioxin/PCB exposure—suckling calves and laying hens housed outdoor—can exceed EU maximum levels at soil concentrations that have previously been considered as safe. Maximum permitted levels can already be exceeded in beef/veal when soil is contaminated around 5 ng PCB-TEQ/kg dry matter (dm). For eggs/broiler, this can occur at a concentration of PCDD/Fs in soil below 5 ng PCDD/F–PCB-TEQ/kg dm. Egg consumers—especially young children—can easily exceed health-based guidance values (TDI). The soil–chicken egg exposure pathway is probably the most sensitive route for human exposure to both dl-PCBs and PCDD/Fs from soil and needs to be considered for soil guidelines. The study also found that calves from suckler cow herds are most prone to the impacts of dl-PCB contamination due to the excretion/accumulation via milk. PCB (and PCDD/F) intake for free-range cattle stems from feed and soil. Daily dl-PCB intake for suckler cow herds must in average be less than 2 ng PCB-TEQ/day. This translates to a maximum concentration in grass of 0.2 ng PCB-TEQ/kg dm which is less than 1/6 of the current EU maximum permitted level. This review compiles sources for PCDD/Fs and PCBs relevant to environmental contamination in respect to food safety. It also includes considerations on assessment of emerging POPs.

Conclusions

The major sources of PCDD/F and dl-PCB contamination of food of animal origin in Germany are (1) soils contaminated from past PCB and PCDD/F releases; (2) PCBs emitted from buildings and constructions; (3) PCBs present at farms. Impacted areas need to be assessed with respect to potential contamination of food-producing animals. Livestock management techniques can reduce exposure to PCDD/Fs and PCBs. Further research and regulatory action are needed to overcome gaps. Control and reduction measures are recommended for emission sources and new listed and emerging POPs to ensure food safety.

     

Sociotechnical design and self-managing work groups: The impact on control

This paper compares employees perceptions of control in 20 manufacturing plants within one corporation. Four of the plants have incorporated self-managing groups as a part of their organizational design, while the other 16 plants have more traditional designs. Survey data from the 20 plants are compared and used to test a set of hypotheses derived from the literature on Sociotechnical systems. These analyses indicate that the workers and supervisors in the Sociotechnical plants have higher levels of perceived control than do their counterparts in the more traditional plants. Top and middle management respondents, how- ever, have similar perceptions of control in both the Sociotechnical and traditional plants. Discussion focuses on the impact of Sociotechnical design, the measurement of control, and future research issues in Sociotechnical design and self-managing work groups.     

Residential Construction, Land Use and the Environment. Simulations for the Netherlands Using a GIS-Based Land Use Model

The present generation of geographical information systems supports strategic planning processes in several ways. They are able to store, manage and analyse the enormous amount of data needed. Another more output-oriented use is the visualisation of the diversity of locational preferences and perspectives of different interest groups and stakeholders. For the simulation of (more indirect) effects of autonomous or planned developments land use modelling can be applied. A step further is the definition and implementation of a set of indicators that show the impact of land use change on different aspects of space and the environment in order to facilitate the (political) discussions, that are an essential part of strategic planning.This paper focuses on the application of a GIS-based simulation model in the framework of the Fifth National Physical Planning Report in the Netherlands. The simulation model generates future land use in the Netherlands given several growth scenarios and a spatial strategy that comprises both foreseen strategic and autonomous developments. Special attention is paid to residential construction because this is expected to be one of the major driving forces in land use changes. An analysis of residential construction for the period 1980–1995 reveals that residential construction has been relatively concentrated in areas close to existing urban areas. New town policies also played a rather strong role during this period. The presence of natural areas (woods and wetlands) plays a significant though limited role in the choice where to build new dwellings. The simulation results for the year 2020 are used to assess the effects of land use changes for a range of environmental indicators.     

Development of a sampling train for the assessment of particulate fugitive emissions

A prototype portable Fugitive Assessment Sampling Train (FAST), designed to obtain large samples of particulate emissions generated by sources whose configurations preclude sample collection before the diffusion of the emissions into the ambient atmosphere, has been successfully fabricated and tested. The prototype FAST utilizes a combination of commercially available and specially designed equipment to collect a 500 milligram particulate sample in an 8-hour period at locations downwind of most industrial fugitive sources. The particulate sample is separated into inhalable and respirable fractions and provides sufficient material for a complete Level 1 assessment including bioassays. A quantity of organic species larger than C₆, sufficient for mass spectrometry analysis, is collected on a bed of adsorbent resin. The establishment of design criteria and operating parameters, selection and design of hardware components, and the fabrication and initial testing of the FAST are discussed. The results of calibration tests and an initial field trial are presented and a plan for additional development is outlined.     

Ecological Integrity: Concept,Assessment, Evaluation: The Traunsee Case

Definitions and concepts relevant to the evaluation of theEcological Integrity of lakes are discussed herein. Theirapplication to Traunsee, a deep lake located in the AustrianAlps which is affected by wastes of salt- and soda-producingindustries, is evaluated, based on 13 contributions published inthis special issue of Water, Air, and Soil Pollution.: Focus.