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Heather Henson-Ramsey Jay Levine Suzanne Kennedy-Stoskopf Sharon K. Taylor Damian Shea Michael K. Stoskopf 《Environmental Modeling and Assessment》2009,14(3):411-418
A simple and dynamic pharmacokinetic model was developed to predict bioconcentration of organic contaminants in earthworms.
The model was parameterized experimentally by placing Lumbricus terrestris in soil contaminated with 200 μg/cm2 of malathion. The toxicokinetics of malathion uptake, depuration, and degradation in soil is measured. After parameterization,
the model was able to accurately predict the bioconcentration factor of malathion at steady state. Sensitivity analyses were
performed and the rate of absorption was determined to be the most sensitive parameter. Varying the rate of malathion elimination
from earthworm tissues, malathion degradation, and the amount of malathion applied to the soil by 25-fold did not result in
the bioconcentration of malathion. An increase in the rate of malathion absorption into earthworm tissues by 25-fold did result
in bioconcentration. Previously published pharmacokinetic studies on xenobiotics with log K
ow values ranging up to 8.05 were used to test the predictive capacity of the model. The model was able to predict from 83%
to 105% of the experimentally derived bioconcentration factors. 相似文献
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The detrimental effects of a ringing phone on cognitive performance were investigated in four experiments. In Experiments 1 and 2, the effects of different types of sounds (a standard cell phone ring, irrelevant tones and an instrumental song commonly encountered by participants) on performance were examined. In Experiment 1, slower responses were observed in all auditory groups relative to a silence condition, but participants in the ring and song conditions recovered more slowly. In Experiment 2, participants who were warned about the potential for distraction recovered more quickly, suggesting a benefit of this prior knowledge. This investigation continued in a college classroom setting (Experiments 3a and 3b); students were exposed to a ringing cell phone during the lecture. Performance on a surprise quiz revealed low accuracy rates on material presented while the phone was ringing. These findings offer insight into top-down cognitive processes that moderate involuntary orienting responses associated with a common stimulus encountered in the environment. 相似文献
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Terry L Tudor Anne C Woolridge Margaret P Bates Paul S Phillips Sharon Butler Keith Jones 《Waste management & research》2008,26(3):233-240
Changes in environmental legislation and standards governing healthcare waste, such as the Hazardous Waste Regulations are expected to have a significant impact on healthcare waste quantities and costs in England and Wales. This paper presents findings from two award winning case study organizations, the Cardiff and Vale NHS Trust and the Cornwall NHS Trust on 'systems' they have employed for minimizing waste. The results suggest the need for the development and implementation of a holistic range of systems in order to develop best practice, including waste minimization strategies, key performance indicators, and staff training and awareness. The implications for the sharing of best practice from the two case studies are also discussed. 相似文献
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The Klamath River once supported large runs of anadromous salmonids. Water temperature associated with multiple mainstem hydropower facilities might be one of many factors responsible for depressing Klamath salmon stocks. We combined a water quantity model and a water quality model to predict how removing the series of dams below Upper Klamath Lake might affect water temperatures, and ultimately fish survival, in the spawning and rearing portions of the mainstem Klamath. We calibrated the water quantity and quality models and applied them for the hydrometeorological conditions during a 40-year postdam period. Then, we hypothetically removed the dams and their impoundments from the models and reestimated the rivers water temperatures. The principal thermal effect of dam and reservoir removal would be to restore the timing (phase) of the rivers seasonal thermal signature by shifting it approximately 18 days earlier in the year, resulting in river temperatures that more rapidly track ambient air temperatures. Such a shift would likely cool thermal habitat conditions for adult fall chinook (Oncorhynchus tshawytscha) during upstream migration and benefit mainstem spawning. By contrast, spring and early summer temperatures could be warmer without dams, potentially harming chinook rearing and outmigration in the mainstem. Dam removal might affect the rivers thermal regime during certain conditions for over 200 km of the mainstem. 相似文献