Heredity and risk of disease

Mathematical modeling of competing risks often uses a single risk function for all individuals within a population. In this paper we use several specific examples to argue that such representations remain approximations until account is taken of the existence of genetic variability within and between populations, and the impact of this upon liability to disease. The extent of human genetic variability is also indicated.     

Exploratory techniques for the determination of potential dose-response relationships between human health and air pollution

This paper seeks to verify the usefulness of selected multivariate statistical techniques for exploring new dose-response relationships between human health and air pollution. We do so by comparing our results with those already established in the literature through hypothesis testing procedures or laboratory work. This use of multivariate techniques is pretheoretical and should be interpreted as suggesting relationships which warrant further investigation with more traditional methodologies. Our results conform very well with those existing in the literature and lend credence to the use of such pretheoretical statistical methods.     

WATER QUALITY PLANNING FOR THE DELAWARE ESTUARY - AN EXAMPLE1

ABSTRACT: The Delaware Estuary has been intensively studied but the planning for water quality control is very unsatisfactory, including the most recent interagency plan. Earlier planning by the FWPCA and the Delaware River Basin Commission was better; but this planning appears to have been halted and perhaps superseded by the provisions of PL 92–500. The Tocks Island reservoir planned to maintain minimum flows may never be built on account of environmental objections; but the consequences of such a decision are not being faced. Meanwhile recent research indicates that urban runoff will be a major influence possibly adding a load of as much as 500,000 lbs. of BOD in a single storm. Unit costs of treating urban runoff pollution are very high, due to its extreme variability. Artificial aeration or oxygenation may provide a more economical means of improving the dissolved oxygen regimen, as compared to primary treatment of urban runoff, or tertiary treatment of effluents. In any event planning on a regional basis is desirable in the Delaware and elsewhere, and Pl 92–500 may need to be changed to facilitate it.     

Older driver crash rates in relation to type and quantity of travel

It is a well-established phenomenon that, notwithstanding their overall good crash record, older drivers have a higher than average rate of involvement in injury crashes when the rate is calculated by dividing crash numbers by distance driven. It has been hypothesised that at least some of this higher crash rate is an artefact of the different nature of driving undertaken by many older drivers. For example, driving in congested urban environments provides more opportunities for collisions than driving the same distance on a motorway. However, there have been few opportunities to investigate this theory, as relevant data are difficult to acquire. High-quality data from the New Zealand Travel Survey (1997/1998) were combined with crash data to enable a statistical model to estimate the risk of driver groups under various driving conditions characterised by the type of road used, time of day, day of week, and season of year. Despite elevated crash risks per distance driven compared with middle-aged drivers for most road types, older drivers were as safe as any other age group when driving on motorways. Accounting for the fragility of older drivers and their passengers in the risk estimates for other road types, older drivers appeared to have daytime risks comparable to 25-year-olds and night-time risks as low as any other age group. The driving patterns of older drivers (in terms of when and where they drive) were estimated to minimize their risks in comparison with the driving patterns of other age groups. These results are of interest to both policy makers and transportation planners working against the background of inevitable increases in the number of older drivers as the population ages.     

In situ soil treatments to reduce the phyto- and bioavailability of lead, zinc, and cadmium

A study was established near a former Zn and Pb smelter to test the ability of soil amendments to reduce the availability of Pb, Zn, and Cd in situ. Soil collected from the field was amended in the lab with P added as 1% P-H3PO4, biosolids compost added at 10% (referred to hereafter as "compost"), and a high-Fe by-product (referred to hereafter as "Fe") + P-triple superphosphate (TSP) (2.5% Fe + 1% P-TSP) and incubated under laboratory conditions at a constant soil pH. Changes in Pb bioavailability were measured with an in vitro test and a feeding study with weanling rats. Field-amended and incubated soils using these plus additional treatments were evaluated using the in vitro extraction and tall fescue (Festuca arundinacea Schreb. cv. Kentucky-31) metal concentration. Reductions were observed across all parameters but were not consistent. In the feeding study, the 1% P-H3PO4 and compost treatments resulted in a decrease of 26% in rat tissue Pb concentration compared with the control soil. The 2.5% Fe + 1% P-TSP showed a 39% decrease. The 1% P-H3PO4 treatment caused the greatest reduction in in vitro extractable Pb from field samples (pH 2.2) with a measured reduction of 66%, while the compost treatment had a 39% reduction and the 2.5% Fe + 1% P-TSP treatment a 50% reduction. The in vitro extraction (pH 1.5) run on field samples showed no reduction in the compost or Fe treatments. The 1% P-H3PO4 treatment was the most effective at reducing plant Pb, Zn, and Cd.     

Evaluation of the potential of laser-induced breakdown spectroscopy for detection of trace element in liquid

The analytical figure of merit of the potential of laser-induced breakdown spectroscopy (LIBS) has been evaluated for detection of trace element in liquid. LIBS data of Mg, Cr, Mn, and Re were studied. Various optical geometries, which produce the laser spark in and at the liquid sample, were tested. The calibration curves for Mg, Cr, Mn, and Re were obtained at the optimized experimental conditions with bulk liquid and in liquid jet. It was found that measurements using a liquid jet provide better detection limits than bulk liquid measurements. The limits of detection (LOD) of Mg, Cr, Mn, and Re in the present liquid jet measurement are found to be 0.1, 0.4, 0.7, and 8 ppm, respectively. The LOD of Mg using Mg 279.55 nm was compared with the values found in other liquid work.