Prenatal diagnosis in autosomal dominant Beckwith-Wiedemann syndrome

A 20-year-old woman with Beckwith-Wiedemann syndrome (BWS) was ultrasonographically appraised at intervals during her pregnancy. Unequivocal evidence for a diagnosis of BWS was obtained in the fetus and this was confirmed postnatally. Early ultrasound diagnosis enabled appropriate genetic counselling to be given; neonatal complications, such as hypoglycaemic episodes, were prevented.     

Measurements of carbonyls in a 13-story building

BACKGROUND, AIM AND SCOPE: Formaldehyde and acetaldehyde are emitted by many mobile and stationary sources and secondary aldehydes are intermediates in the photo-oxidation of organic compounds in the atmosphere. These aldehydes are emitted indoors by many materials such as furniture, carpets, heating and cooling systems, an by smoking. Carbonyls, mainly formaldehyde and acetaldehyde, have been studied because of their adverse health effects. In addition, formaldehyde is a suspected carcinogen. Therefore, the concentrations of formaldehyde and acetaldehyde were determined to assess the inhalation exposure doses to carbonyls for people who work in a 13-story building and in order to evaluate the cancer hazard. METHODS: Carbonyl compounds in indoor and outdoor air were measured at a 13-story building located in Mexico City. The mezzanine, fifth and tenth floors, and the third level-parking garage were selected for sampling. Samples were collected in two sampling periods, the first from April 20 to 29, 1998 and the second from December 1 to 20, 1998. Carbonyls were sampled by means of DNHP-coated cartridges at a flow rate of 1 l min(-1) from 9:00 to 19:00 hours, during 2-hour time intervals and analyzed by HPLC with hours, during 2-hour time intervals and analyzed by HPLC with UV/VIS detection. RESULTS: Mean carbonyl concentrations were highest in the 3rd level-parking garage, with the formaldehyde concentration being the highest ranging from 108 to 418 microg m(-3). In working areas, the highest carbonyl arithmetic mean concentrations (AM) were observed on the 5th floor. Acetone and formaldehyde concentrations were highest in April ranging from 161 to 348 microg m(-3) (AM = 226) and from 157 to 270 microg m(-3) (AM = 221), respectively. Propionaldehyde and butyraldehyde were present in smaller concentrations ranging from 2 to 25 and 1 to 28 microg m(-3), respectively, considering all the samples. Mean indoor/outdoor ratios of carbonyls ranged from 1.8 to 9.6. A reduction of inhalation exposure doses of 41% and 45% was observed in the fifth floor air after the air conditioning systems had been repaired. Formaldehyde and acetaldehyde concentrations were higher in smoking environments. CONCLUSION: Indoor carbonyl concentrations were significantly greater than outdoor concentrations. Tobacco smoke seems to be the main indoor source of formaldehyde. After the air conditioning system was maintained and repaired (as was recommended), an important reduction in the emission of formaldehyde and acetaldehyde was achieved on all floors, except for the 3rd level parking garage, thereby reducing the inhalation exposure doses. RECOMMENDATION: The results obtained in this research demonstrated that maintenance of air conditioning systems must be carried out regularly in order to avoid possible adverse effects on health. Additionally, it is mandatory that isolated smoking areas, with air extraction systems, be installed in every public building.     

LIVESTOCK GRAZING MANAGEMENT IMPACTS ON STREAM WATER QUALITY: A REVIEW1

ABSTRACT: Controlling agricultural nonpoint source pollution from livestock grazing is a necessary step to improving the water quality of the nation's streams. The goal of enhanced stream water quality will most likely result from the implementation of an integrated system of best management practices (BMPs) linked with stream hydraulic and geomorphic characteristics. However, a grazing BMP system is often developed with the concept that BMPs will function independently from interactions among controls, climatic regions, and the multifaceted functions exhibited by streams. This paper examines the peer reviewed literature pertaining to grazing BMPs commonly implemented in the southern humid region of the United States to ascertain effects of BMPs on stream water quality. Results indicate that the most extensive BMP research efforts occurred in the western and midwestern U.S. While numerous studies documented the negative impacts of grazing on stream health, few actually examined the success of BMPs for mitigating these effects. Even fewer studies provided the necessary information to enable the reader to determine the efficacy of a comprehensive systems approach integrating multiple BMPs with pre‐BMP and post‐BMP geomorphic conditions. Perhaps grazing BMP research should begin incorporating geomorphic information about the streams with the goal of achieving sustainable stream water quality.     

Conservation or Commercial Management of Temperate Forests of Baja California Sur, Mexico

The current status of the oak and oak-pine forests in the Sierra de La Laguna range of the Baja California peninsula is examined from four perspectives: (1) the structural analysis of the woodlands; (2) the natural regeneration of hurricane windfall clearings and its effect on the oak-pine community; (3) the density, mortality, size, and commercial potential of the only pine species Pinus lagunae; and (4) the possible destruction of this endemic species by attack from moths. These factors were evaluated to make recommendations regarding the management and/or commercialization of the forest resources of this proposed Biosphere Reserve. Results show that the oak woodlands occurring at low elevations contain many tropical plants from the tropical dry forest that surrounds these woodlands, and that the tropical elements decrease at higher altitudes. In forest gaps, oaks were more abundant than pines. Gaps contained a lower diversity of perennial plants than mature oak-pine forest. P. lagunae has a high adult mortality, which can be attributed to the joint effect of fire and insect attack. Results indicate that the forest in this region does not have timber-yielding potential because of the small area it covers and because of the low tree diameters and volume, which are insufficient to carry out a continuous and income-producing extraction of the pine resource of Baja California Sur. Finally, options for management are discussed and future studies are proposed to determine the life cycle and extent of the moth populations.     

Interrogating Social Sustainability in the Biofuels Sector in Latin America: Tensions Between Global Standards and Local Experiences in Mexico,Brazil, and Colombia

Across the Americas, biofuels production systems are diverse due to geographic conditions, historical patterns of land tenure, different land use patterns, government policy frameworks, and relations between the national state and civil society, all of which shape the role that biofuels play in individual nations. Although many national governments throughout the Americas continue to incentivize growth of the biofuels industry, one key challenge for biofuels sustainability has been concern about its social impacts. In this article, we discuss some of the key social issues and tensions related to the recent expansion of biofuels production in Mexico, Colombia, and Brazil. We argue that a process of “simplification” of ecological and cultural diversity has aided the expansion of the biofuels frontier in these countries, but is also undermining their viability. We consider the ability of governments and non-state actors in multi-stakeholder initiatives (MSI) to address social and environmental concerns that affect rural livelihoods as a result of biofuels expansion. We analyze the tensions between global sustainability standards, national level policies for biofuels development, and local level impacts and visions of sustainability. We find that both government and MSI efforts to address sustainability concerns have limited impact, and recommend greater incorporation of local needs and expertise to improve governance.     

Perceived workplace racial discrimination and its correlates: A meta‐analysis

We combine the interactional model of cultural diversity (IMCD) and relative deprivation theory to examine employee outcomes of perceived workplace racial discrimination. Using 79 effect sizes from published and unpublished studies, we meta‐analyze the relationships between perceived racial discrimination and several important employee outcomes that have potential implications for organizational performance. In response to calls to examine the context surrounding discrimination, we test whether the severity of these outcomes depends on changes to employment law that reflect increasing societal concern for equality and on the characteristics of those sampled. Perceived racial discrimination was negatively related to job attitudes, physical health, psychological health, organizational citizenship behavior, and perceived diversity climate and positively related to coping behavior. The effect of perceived racial discrimination on job attitudes was stronger in studies published after the Civil Rights Act of 1991 was passed than before. Results provide some evidence that effect sizes were stronger the more women and minorities were in the samples, indicating that these groups are more likely to perceive discrimination and/or respond more strongly to perceived discrimination. Our findings extend the IMCD and relative deprivation theory to consider how contextual factors including changes to employment law influence employee outcomes of perceived workplace discrimination. Copyright © 2015 John Wiley & Sons, Ltd.     

Determining sediment quality for regulatory proposes using fish chronic bioassays

Sediment quality assessments for regulatory purposes (i.e. dredged material disposal) are characterized by linking chemical and acute ecotoxicological data. The design of chronic bioassays that incorporate more sensible endpoints than acute tests is discussed to address sediment quality for environmental quality assessment and regulatory proposes. The chronic tests use juveniles of commercial species of fish Sparus aurata and Solea senegalensis, to assess sediment toxicity in samples collected along different littoral areas in the North and the South of Spain. The organisms were exposed during 60 days and sublethal endpoints were selected including biomarkers of exposure to metals (metallothioneins - MTs) and to organic contaminants (ethoxyresorufin-O-deethylase activity - EROD activity) and biomarkers of effect (histopathology in different tissues, gill and liver). A Multivariate Analysis Approach was conducted in order to associate these biological responses with sediment metal concentration from the ports and with chemical residues in biological tissues exposed to sediments under laboratory conditions.     

Genealogical Analysis of a Closed Herd of Black Hairless Iberian Pigs

Abstract: Livestock breeds are recognized as important components of world biodiversity. The Iberian pig is a swine breed well adapted to the Mediterranean forest ecosystem and provides cured products of high quality. The ancient population of Iberian pigs (  Sus scrofa meridionalis ) was differentiated in several local types, the black hairless pigs representing the fattest genetic type. The conservation program of the Guadyerbas strain has maintained this germplasm isolated since 1945 as a closed population in an experimental herd. The complete pedigree, with 1000 breeding animals descending from 24 founders, has been used to measure along the successive cohorts of breeding animals the effective number of founders, effective number of nonfounders, founder genome equivalents, and expected number of founders' surviving alleles. For the last cohort, the values were 10.34, 1.42, 1.25, and 4.06, respectively. The evolution of inbreeding and coancestry and its components attributable to each founder were also studied. The rate of increase in inbreeding and coancestry was 2.21% per cohort, or 0.906% per year. Finally, the effect of family structure and mating tactics on the evolution of coancestry was also analyzed. The greatest rates of coancestry per cohort were attributable to unbalanced family sizes, and the use of minimum coancestry matings effectively delayed the increase in inbreeding.     

A multibiomarker approach using the polychaete Arenicola marina to assess oil-contaminated sediments

Background, aim and scope  

Marine and coastal sediments can accumulate substantial concentrations of metals and hydrocarbons, yet the consequences of this contamination for exposed biota in situ can be difficult to establish. Here, we examine the hypothesis that exposure to contaminated sediments can lead to detrimental effects in sediment-dwelling species. The combination of chemical and biological assessment allows the identification of the impact of chemical contamination, and their use as assessment tools is becoming increasingly important.