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171.
172.
George I. Solish Hugo W. Moser Laura D. Ringer Ann E. Moser Carol Tiffany Edward Schutta 《黑龙江环境通报》1985,5(1):27-34
The prenatal diagnosis of the cerebro-hepato-renal syndrome of Zellweger (CHRS) was made by assaying the levels of very long chain fatty acids (VLCFAs) in amniotic fluid cell cultures, obtained by amniocentesis at 16 1/2 weeks of pregnancy. The family-at-risk, because they had previously borne a child with CHRS, accepted these results as indications of an affected fetus, and chose to terminate the pregnancy at 20 1/2 weeks of gestation. The diagnosis was confirned by the phenotype of the aborted fetus and the presence of markedly elevated levels of VLCFAs in fetal liver homogenates. The prenatal diagnosis of CHRS, which can now readily be determined from amniotic fluid cell cultures, is an important step in genetic counselling of families-at-risk for this disease. 相似文献
173.
Tait Chirenje Lena Q. MaMing Chen Edward J. Zillioux 《Advances in Environmental Research》2003,8(1):137-146
Arsenic contamination is of great environmental concern due to its toxic effects as a carcinogen. Knowledge of arsenic background concentrations is important for land application of wastes and for making remediation decisions. The soil clean-up target level for arsenic in Florida (0.8 and 3.7 mg kg−1 for residential and commercial areas, respectively) lies within the range of both background and analytical quantification limits. The objective of this study was to compare arsenic distribution in urban and non-urban areas of Florida. Approximately 440 urban and 448 non-urban Florida soil samples were compared. For urban areas, soil samples were collected from three land-use classes (residential, commercial and public land) in two cities, Gainesville and Miami. For the non-urban areas, samples were collected from relatively undisturbed non-inhabited areas. Arsenic concentrations varied greatly in Gainesville, ranging from 0.21 to approximately 660 mg kg−1 with a geometric mean (GM) of 0.40 mg kg−1, which were lower than Miami samples (ranging from 0.32 to 112 mg kg−1; GM=2.81 mg kg−1). Arsenic background concentrations in urban soils were significantly greater and showed greater variation than those from relatively undisturbed non-urban soils (GM=0.27 mg kg−1) in general. 相似文献
174.
Lillian Y. F. Hsu MD Sara Kaffe Edmund C. Jenkins Lita Alonso Peter A. Benn Karen David Kurt Hirschhorn Ernest Lieber Alan Shanske Lawrence R. Shapiro Edward Schutta Dorothy Warburton 《黑龙江环境通报》1992,12(7):555-573
Currently, accepted protocol which has been developed at the Prenatal Diagnosis Laboratory of New York City (PDL) requires that when a chromosome abnormality is found in one or more cells in one flask, another 20–40 cells must be examined from one or two additional flasks. Chromosome mosaicism is diagnosed only when an identical abnormality is detected in cells from two or more flasks. In a recent PDL series of 12 000 cases studied according to this protocol, we diagnosed 801 cases (6.68 per cent) of single-cell pseudomosaicism (SCPM), 126 cases (1.05 per cent) of multiple-cell pseudomosaicism (MCPM), and 24 cases (0.2 per cent) of true mosaicism. Pseudomosaicism (PM) involving a structural abnormality was a frequent finding (2/3 of SCPM and 3/5 of MCPM), with an unbalanced structural abnormality in 55 per cent of SCPM and 24 per cent of MCPM. We also reviewed all true mosaic cases (a total of 50) diagnosed in the first 22000 PDL cases. Of these 50 cases, 23 were sex chromosome mosaics and 27 had autosomal mosaicism; 48 cases had numerical abnormalities and two had structural abnormalities. Twenty-five cases of mosaicism were diagnosed in the first 20 cells from two flasks, i.e., without additional work-up, whereas the other 25 cases required extensive work-up to establish a diagnosis (12 needed additional cell counts from the initial two culture flasks; 13 required harvesting a third flask for cell analysis). Our data plus review of other available data led us to conclude that rigorous efforts to diagnose true mosaicism have little impact in many instances, and therefore are not cost-effective. On the basis of all available data, a work-up for potential mosaicism involving a sex chromosome aneuploidy or structural abnormality should have less priority than a work-up for a common viable autosomal trisomy. We recommend revised guidelines for dealing with (1) a numerical versus a structural abnormality and (2) an autosomal versus a sex chromosome numerical aneuploidy. Emphasis should be placed on autosomes known to be associated with phenotypic abnormalities. These new guidelines, which cover both flask and in situ methods, should result in more effective prenatal cytogenetic diagnosis and reduced patient anxiety. 相似文献
175.
Lance A. Waller Brett J. Goodwin Mark L. Wilson Richard S. Ostfeld Stacie L. Marshall Edward B. Hayes 《Environmental and Ecological Statistics》2007,14(1):83-100
We present an exploratory analysis of reported county-specific incidence of Lyme disease in the northeastern United States
for the years 1990–2000. We briefly review the disease ecology of Lyme disease and the use of risk maps to describe local
incidence as estimates of local risk of disease. We place the relevant elements of local environmental and ecological variables,
local disease incidence, and (importantly) local disease reporting in a conceptual context to frame our analysis. We then
apply hierarchical linear models of increasing complexity to summarize observed patterns in reported incidence, borrowing
information across counties to improve local precision. We find areas of increasing incidence in the central northeastern
Atlantic coast counties, increasing incidence branching to the north and west, and an area of fairly stable and slightly decreasing
reported incidence in western New York. 相似文献
176.
Haruna Amano Toshiaki Fujita Naoshi Hiramatsu Sayumi Sawaguchi Takahiro Matsubara Craig V. Sullivan Akihiko Hara 《Marine Biology》2007,150(6):1215-1225
Coralliophila abbreviata (Lamarck) is a corallivorous gastropod that lives and feeds on several species of scleractinian coral in the Western Atlantic
and Caribbean. Previous studies of C. abbreviata have revealed that snails on branching acroporid corals are larger and consume more tissue than those on massive and plating
corals. To ascertain whether snail life-history and fitness are differentially affected by the coral host, an analysis of
the age structure and female reproductive output of snail populations on three coral host taxa (Acropora palmata, Diploria spp., and Montastraea spp.) was conducted at four shallow (2–7 m depth) reef sites off Key Largo, Florida in June through August, 2004. Snails
were, on average, almost twice as large on A. palmata than on Diploria spp. and Montastraea spp., averaging 30.3 mm shell length, compared to 17.2 and 17.6 mm, respectively. Brood size increased as a power function
with female shell length. Females on A. palmata were significantly larger than females on the other two hosts and, therefore, produced more offspring per female. The number
of growth striae on the inner surface of the operculum was used to estimate snail age. Estimates of growth rate were obtained
by fitting the Gompertz growth function to size-at-age plots and mortality was estimated using growth parameters and size-frequency
data. The data suggest that C. abbreviata inhabiting A. palmata are larger than on alternative hosts due to a combination of a faster growth rate and longer life-span. The species is believed
to be a protandrous hermaphrodite. The timing of sex change varied among hosts; snails on A. palmata changed sex later at larger sizes relative to those on the other two hosts. Based on these results, it seems probable that
C. abbreviata has developed reaction norms for life-history traits, allowing snails to adjust and maximize fitness in the different environments
associated with various coral hosts. 相似文献
177.
R. W. Brill D. B. Holts R. K. C. Chang S. Sullivan H. Dewar F. G. Carey 《Marine Biology》1993,117(4):567-574
We measured the vertical and horizontal movements of striped marlin (Tetrapturus audax) off the leeward coast of the Island of Hawaii between 20 November and 18 December 1992 while simultaneously gathering data on water temperature and oceanic currents. Fish movements were monitored by ultrasonic depth-sensitive transmitters, depth-temperature profiles by an expendable bathythermograph system, and oceanic current patterns by an acoustic Doppler current profiler. Like Indo-Pacific blue marlin (Makaira mazara), striped marlin near Hawaii spend >85% of their time in the mixed layer (i.e., above 90 m depth). The maximum depth for striped marlin appears to be limited by water temperatures 8 C° colder than the mixed layer, rather than by an absolute lower temperature. We also found that the horizontal displacements of some striped marlin can be strongly influenced by currents. 相似文献
178.
The in-situ solid/pore-water partitioning of tributyltin (TBT), dibutyltin (DBT) and monobutyltin (MBT) was determined for an estuarine sediment profile collected from a commercial marina. Total butyltin levels exceeded sediment quality guideline values, and were 220-8750 microg/kg for TBT, 150-5450 microg/kg for DBT and 130-4250 microg/kg for MBT. Pore-water butyltin concentrations ranged from 0.05 to 2.35 microg/l for TBT, 0.07-3.25 microg/l for DBT, and 0.05-0.53 microg/l for MBT. The partitioning of butyltin compounds between the sediment solid-phase and pore-water was described by an organic carbon normalised distribution ratio (D(OC)). The observed D(OC) values were similar for TBT, DBT and MBT, and were 10(5)-10(6) l/kg. Values for the Butyltin Degradation Index (BDI) were larger than 1 at depths greater than 10 cm below the sediment/water-column interface. This indicates that substantial TBT degradation has occurred in the sediments, and suggests that natural attenuation may be a viable sediment remediation strategy. 相似文献
179.
Factors affecting the transport and retention of Cd, Cr, Cu, Ni, Pb and Zn in acidic groundwaters as they pass through estuarine sediments were investigated using column experiments. Acidic groundwaters caused the rapid dissolution of iron sulfide (AVS) and other iron and manganese phases from sediments that are important for metal binding and buffering. Metal breakthrough to overlying water occurred in the order of Ni>Zn>Cd>Cu>Cr/Pb. Metal transport increased as the sediment permeability increased, reflecting the low resistance to flow caused by larger sand-sized particles and the decreased abundance of metal adsorption sites on these materials. Metal mobility increased as the groundwater pH decreased, as flow rate or metal concentrations increased, and as the exposure duration increased. Groundwater Cr and Pb were promptly attenuated by the sediments, the mobility of Cu was low and decreased rapidly as sediment pH increased above 4.5, while Cd, Ni and Zn were the most easily transported to the surface sediments and released to the overlying waters. For groundwaters of pH 3, metal migration velocities through sandy sediments were generally 0.5-2% (Cr, Pb), 1-6% (Cu) and 4-13% (Cd, Ni, Zn) of the total groundwater velocity (9-700 m/yr). The oxidative precipitation of Fe(II) and Mn(II) in the groundwaters did not affect metal mobility through the sediments. The results indicated that the efflux of acidic and metal-contaminated groundwater through estuarine sediments would affect organisms resident in sandy sediments more greatly than organisms resident in fine-grained, silty, sediments. 相似文献
180.
The kinetics of oxidation of methylhydrazine () and 1,1-dimethylhydrazine () by dissolved oxygen in water has been measured at various acidities as a function of catalyst (cupric ion) concentration. In dilute solutions the oxidation occurs through a cupric ion catalyzed process as well as by an uncatalyzed step. The extent of formation of nitrosodimethylamine () depends upon the initial concentration. In dilute solutions is not formed, but in more concentrated solutions, formation increases with increasing content, reaches a maximum at 60–80% (by volume) and then decreases. The yield appears to approximately parallel the viscosity of the medium, and it is speculated that the factors which control viscosity may also be responsible for governing formation. 相似文献