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András Tóth Erika P. Tardy Sándor Gombos Krisztina Hajdu József Bátorfi Csilla Krausz 《黑龙江环境通报》2001,21(4):253-255
A case of prenatally diagnosed Yq deletion is described. Fluorescence in situ hybridisation (FISH) was used to identify the abnormal chromosome and to exclude mosaicism. Based on the cytogenetic result and the ultrasound investigation the pregnancy was continued. A newborn with normal male genitalia was delivered. Microdeletion analysis of the Yq showed the absence of the AZFc region. This type of deletion has been described as being associated with azoospermia or oligozoospermia with a progressive decrease of sperm number over time. Long-term andrological follow-up of the newborn will be necessary with eventual cryoconservation of sperm at early adulthood. The present report proposes that AZF analysis combined with FISH has an important role in accurate genetic counselling in sex chromosome anomalies. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
264.
Males of the gypsy moth, Lymantria dispar, are attracted by a pheromone released by females. Pheromones are detected by olfactory neurons housed in specialized sensory
hairs located on the antennae of the male moth. Once pheromone molecules enter the sensilla lymph, a highly abundant pheromone-binding
protein (PBP) transports the molecule to the sensory neuron. The PBPs are members of the insect odorant-binding protein family,
with six conserved cysteine residues. In this study, the disulfide bond connectivities of the pheromone-binding proteins PBP1
and PBP2 from the gypsy moth were found to be cysteines 19–54, 50–109, and 97–118 for PBP1, and cysteines 19–54, 50–110, and
97–119 for PBP2, as determined by cyanylation reactions and cyanogen bromide chemical cleavage. We have discovered that the
second disulfide linkage is the most easily reduced of the three, and this same linkage is missing among four cysteine-containing
insect odorant-binding proteins (OBPs). We are the first to identify the unique steric and electronic properties of this second
disulfide linkage.
Electronic Supplementary Material Supplementary material is available for this article at
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Erika PlettnerEmail: |