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91.
Ken Kin Lam Yung Pengfei Fu Yufei Zhao Chuan Dong Zongwei Cai Ruijin Li 《环境科学学报(英文版)》2022,34(12):25-40
Fine particulatematter (PM2.5) is associated with increased risks of Alzheimer’s disease (AD),yet the toxicologicalmechanisms of PM2.5 promoting AD remain unclear. In this study,wildtype
and APP/PS1 transgenic mice (AD mice) were exposed to either filtered air (FA) or PM2.5 for eight weeks with a real-world exposure system in Taiyuan, China (mean PM2.5 concentration
in the cage was 61 μg/m3). We found that PM2.5 exposure could remarkably aggravate AD mice’s ethological and brain ultrastructural damage, along with the elevation of the pro-inflammatory cytokines (IL-6 and TNF-α), Aβ-42 and AChE levels and the decline of ChAT levels in the brains. Based on high-throughput sequencing results, some differentially expressed (DE) mRNAs and DE miRNAs in the brains of AD mice after PM2.5 exposure were screened.Using RT-qPCR, seven DEmiRNAs (mmu-miR-193b-5p, 122b-5p, 466h-3p, 10b-5p, 1895, 384–5p, and 6412) and six genes (Pcdhgb8, Unc13b, Robo3, Prph, Pter, and Tbata)
were evidenced the and verified. Two miRNA-target gene pairs (miR-125b-Pcdhgb8 pair and miR-466h-3p-IL-17Rα/TGF-βR2/Aβ-42/AChE pairs) were demonstrated that they were more
related to PM2.5-induced brain injury. Results of Gene Ontology (GO) pathways and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways predicted that synaptic and postsynaptic
regulation, axon guidance, Wnt, MAPK, and mTOR pathways might be the possible regulatory mechanisms associated with pathological response. These revealed that PM2.5-
elevated pro-inflammatory cytokine levels and PM2.5-altered neurotransmitter levels in AD mice could be the important causes of brain damage and proposed the promising miRNA
andmRNA biomarkers and potentialmiRNA-mRNA interaction networks of PM2.5-promoted AD. 相似文献
92.
新疆玛纳斯河流域灌溉水资源保证程度及提升策略 总被引:2,自引:0,他引:2
从供需两方面,构建了区域灌溉水资源保证程度分析模型,利用该模型对玛纳斯河流域灌溉水资源保证程度进行了分析。结果表明,现状年玛纳斯河流域灌溉水资源保证程度为79.21%,各灌区存在较大的差异,下野地、莫索湾、金安、玛纳斯等灌区灌溉水资源保证程度较低,分别为69.09%、78.76%、78.25%、71.24%,明显处于亏缺状态,而石河子灌区达115.06%,处于相对盈余状态。在各灌区灌溉总面积维持现有数量以及保证灌区水资源安全的前提下,随着加大部分灌区(金安、玛纳斯和石河子灌区)地下水资源开发力度,大力发展高新节水技术以及调整种植结构,近期流域灌溉水资源保证程度总体可接近100%,但流域内除石河子灌区外,下野地、莫索湾、金安、玛纳斯等灌区灌溉水资源仍处于亏缺状态。2020年随着各种综合措施的进一步实施,全流域灌溉保证程度将增加至113.19%,各灌区将实现灌溉水资源供需平衡。最后,针对3类不同灌溉水资源保证程度地区的水资源利用状况,提出了差别化的提升策略。 相似文献
93.
三峡工程库区巫山段干支流水质变化分析研究 总被引:2,自引:0,他引:2
文章采用巫山县环境监测站2002年到2008年监测资料,对三峡工程蓄水后库区巫山段水质进行了评价与分析。结果表明:蓄水后三峡库区长江干流巫山段总体水质良好;未受到重金属、石油类和挥发性酚类物质污染;总氮和总磷指标偏高;水体处于中营养状态水平。蓄水后一级支流总磷、总氮指标升高,水质类别上升,水质有恶化的趋势;水流变缓,气候条件和营养盐浓度适宜,在一级支流回水敏感区的部分河段爆发了“水华”,富营养化的潜在风险升高。在营养水平和气候条件相当的情况下,支流回水区常爆发“水华”而干流未出现“水华”现象,说明水动力条件是发生水体富营养化的主要诱发因子。 相似文献
94.
95.
Removal of heavy metal ions from wastewaters: a review 总被引:30,自引:0,他引:30
Heavy metal pollution has become one of the most serious environmental problems today. The treatment of heavy metals is of special concern due to their recalcitrance and persistence in the environment. In recent years, various methods for heavy metal removal from wastewater have been extensively studied. This paper reviews the current methods that have been used to treat heavy metal wastewater and evaluates these techniques. These technologies include chemical precipitation, ion-exchange, adsorption, membrane filtration, coagulation-flocculation, flotation and electrochemical methods. About 185 published studies (1988-2010) are reviewed in this paper. It is evident from the literature survey articles that ion-exchange, adsorption and membrane filtration are the most frequently studied for the treatment of heavy metal wastewater. 相似文献
96.
John W. Wang Henrique C. G. Do Nascimento Teh Fu Yen 《Resources, Conservation and Recycling》1989,2(4)
Biodegradation of nitrogen-enriched lignite by soil bacteria previously acclimated in hydrogen peroxide-acetic acid lignitic substrate was carried out to assess the effects of nitrogen functional groups on the biodegradation of lignite. Chlorination, oxidation plus nitration, and ammoniation were applied in an attempt to modify the chemical structure of lignite so as to obtain a lignitic substrate that is more compatible to the enzymatical system of ordinary soil bacteria than that of unmodified lignite. Incorporation of nitrogen containing functional groups into lignite structure achieved 4.71 wt%, a value five times higher than that usually found in unmodified (raw) lignite. Data collected through a 16 day incubation time, monitoring production as well as depletion of both nitrate and organic acids, concluded that biodegradation was expedited by the incorporation of nitrogen into the structure of lignite. Twenty-eight compounds were identified based on the results from GC/MS analysis of the products. 相似文献
97.
98.
99.
对珠江三角洲水体中来源广、毒性大的多氯代芳香化合物(PCAs)在两种自然沉积物和活性污泥中的吸附特征进行了初步研究。研究结果表明,在珠江广州河段鸦岗底泥和顺德鱼塘底泥中,1,2,4-三氯苯、1,2,4,5-四氯苯、五氯苯主要呈现为Fruendlich非线性吸附,六氯苯、2,4,6-三氯酚、七氯和Aroclor1260则表现为线性吸附;而在活性污泥颗粒物上几种PCAs均表现为线性吸附。PCAs的吸附行为与Kow有一定关系,但主要与固体颗粒物中有机碳和粘土成分含量有关。有机碳和粘土成分的高低不仅影响PCAs在颗粒物上吸附容量的大小,其比值还决定了PCAs的吸附方式。 相似文献
100.