Fungicidal activity and molecular modeling of fusarubin analogues from Fusarium oxysporum

Abstract

Fusarubin analogues of Fusarium oxysporum f. sp. ciceris were investigated for antifungal activity in vitro against five soil borne phytopathogenic fungi. 3-O-Methyl-8-O-methyl-fusarubin was inhibitory towards S. sclerotiorum (EC₅₀ 0.33?mmol L^?1) and Sclerotium rolfsii (EC₅₀ 0.38?mmol L^?1). A structure–antifungal activity relationship of fusarubin analogues was established from their activity performance. Possible mechanism of action of these compounds was studied using molecular docking and simulations against three target enzymes which revealed receptor ligand binding affinity. Docking of 3-O-methyl-8-O-methyl-fusarubin into the succinate dehydrogenase site revealed formation of salt bridge, hydrogen bond, π–anion, π–alkyl, and Van der Waals interactions.     

Analytical solution of two-dimensional advection–dispersion equation with spatio-temporal coefficients for point sources in an infinite medium using Green’s function method

In the present study analytical solutions of a two-dimensional advection–dispersion equation (ADE) with spatially and temporally dependent longitudinal and lateral components of the dispersion coefficient and velocity are obtained using Green’s Function Method (GFM). These solutions describe solute transport in infinite horizontal groundwater flow, assimilating the spatio-temporal dependence of transport properties, dependence of dispersion coefficient on velocity, and the particulate heterogeneity of the aquifer. The solution is obtained in the general form of temporal dependence and the source term, from which solutions for instantaneous and continuous point sources are derived. The spatial dependence of groundwater velocity is considered non-homogeneous linear, whereas the dispersion coefficient is considered proportional to the square of spatial dependence of velocity. An asymptotically increasing temporal function is considered to illustrate the proposed solutions. The solutions are validated with the existing solutions derived from the proposed solutions in three special cases. The effect of spatially/temporally dependent heterogeneity on the solute transport is also demonstrated. To use the GFM, the ADE with spatio-temporally dependent coefficients is reduced to a dispersion equation with constant coefficients in terms of new position variables introduced through properly developed coordinate transformation equations. Also, a new time variable is introduced through a known transformation.     

Non-edible vegetable oil–based feedstocks capable of bio-lubricant production for automotive sector applications—a review

Environmental Science and Pollution Research - Fossil fuel resource is on the draining stage which leads to an increment in the cost of the petroleum products. Nowadays, research is focused on the...     

Kinetics and isotherm modeling of azoxystrobin and imidacloprid retention in biomixtures

The paper reports the kinetics and adsorption isotherm modeling for imidacloprid (IMIDA) and azoxystrobin (AZOXY) in rice straw (RS)/corn cob (CC) and peat (P)/compost (C) based biomixtures. The pseudo-first-order (PFO), pseudo-second-order (PSO), Elovich and intraparticle diffusion models were used to describe the kinetics. The adsorption data were subjected to the Langmuir and the Freundlich isotherms. Results (r²_Adj values) suggested that the modified Elovich model was the best suited to explain the kinetics of IMIDA sorption while different models explained AZOXY sorption kinetics in different biomixtures (PFO in RS?+?C and RS?+?P; PSO in CC?+?P and Elovich in CC?+?C). Biomixtures varied in their capacity to adsorb both pesticides and the adsorption coefficient (K_d) values were 116.8–369.24 (AZOXY) and 24.2–293.4 (IMIDA). The Freundlich isotherm better explained the sorption of both pesticides. Comparison analysis of linear and nonlinear method for estimating the Freundlich adsorption constants was made. In general, r²_Adj values were higher for the nonlinear fit (AZOXY?=?0.938–0.982; IMIDA?=?0.91–0.970) than the linear fit (AZOXY?=?0.886–0.993; IMIDA?=?0.870–0.974) suggesting that the nonlinear Freundlich equation better explained the sorption. The rice straw-based biomixtures performed better in adsorbing both the pesticides and can be used in bio-purification systems.     

Immunostimulants for shrimp aquaculture: paving pathway towards shrimp sustainability

Environmental Science and Pollution Research - At present, food security is a matter of debate of global magnitude and fulfilling the feeding requirement of?>?8 billion human...     

Towards greening a university campus: The case of the University of Maribor, Slovenia

The environmental performance of the University of Maribor (Engineering Campus) has been assessed on a life cycle basis. The following activities have been considered in the study: the use and operation of lecture theatres (construction and maintenance, heating, lighting and water consumption) and day-to-day consumption of sundries (paper and plastic bottles). The results indicate that the heating and construction of buildings are the ‘hot spots’ in the system, for most environmental impacts. Different waste management options for the plastic and paper, including recycling, incineration and landfill, have also been compared for environmental impacts and economic costs. The option combining 70% recycling, 29% incineration and 1% landfill has been found to be most economically and environmentally sustainable.     

Discussion of “Mahmodinia,S., & Javan,M. (2021). Vortical structures,entrainment and mixing process in the lateral discharge of the gravity current. Environmental Fluid Mechanics, 21(5), 1035–1067”

Environmental Fluid Mechanics - The authors of the discussed paper presented an interesting study of the lateral gravity currents for the different flow conditions. The authors showed the...     

Heat loss analysis: An approach toward the revival of parabolic dish type solar cooker

Present work investigates a noble approach toward the heat loss analysis of parabolic dish type solar cooker. Various experiments have been done on cooking pot to get the input parameter for calculation purposes. Cooking pot was kept at the focus of a parabolic dish type concentrator and repeated experiments have been done to measure solar radiation intensity (direct and Indirect) using a pyrometer, temperature at the focus of parabolic dish using a thermocouple and air velocity using hot wire anemometer to investigate the heat losses from the cooking pot. In the present article, a numerical approach has been performed to define the new parameter called performance index of the cooking pot which decides how the useful energy of working fluid inside the cooking pot approaches concentration ratio of the parabolic dish type solar cooker. The present analysis shows that the performance index varies from 15.45 to 17.66 and efficiency varies from 85.83% to 98.10% with the time of the day.