Thyroid antibodies are not a risk factor for pregnancies with down syndrome

The observation that thyroid disease is frequent in mothers of children with Down syndrome (DS) has suggested that maternal thyroid antibodies could be a factor predisposing to trisomy 21 in their offspring. In this study, the incidences of thyroglobulin (Tg) and thyroid peroxidase (TPO) antibodies were analysed with a sensitive solid-phase immunosorbent radioassay in sera from 29 mothers giving birth to children with trisomy 21 and 87 control mothers. The serum samples were collected at delivery. There was no statistical difference regarding the proportion of thyroid antibodies (against Tg and/or TPO) in the two groups. Thyroid antibodies were detected in 6/29 (20.7 per cent) of the DS mothers and in 23/87 (26.4 per cent) of the control mothers. Among the women with thyroid antibodies, 4/6 (66.7 per cent) of the DS mothers and 12/23 (52 per cent) of the control mothers had antibodies against both Tg and TPO. There was no increase in the relative risk of having a child with DS if the titre of either Tg or TPO antibodies or both were positive, i.e. ≥ 1/5. The results indicate that the presence of thyroid antibodies in the serum of a pregnant woman has no prognostic value for the birth of an infant with DS.     

Solar Disinfection of Water for Inactivation of Enteric Viruses and its Enhancement by Riboflavin

Solar disinfection (SODIS) has been described as a cheap and effective method of treating contaminated water to inactivate pathogenic microorganisms. In this study, SODIS was assessed for its efficacy in inactivating three enteric viruses (coxsackievirus B3, coxsackievirus B5 and poliovirus), either on its own or in the presence of riboflavin as a disinfection enhancer. On its own, SODIS produced a reduction of virus infectivity of 4–6 log₁₀ in 6 h. In the presence of riboflavin, inactivation was more rapid in all viruses studied, and with coxsackievirus B5 and poliovirus an extra 1–2 log₁₀ increase in reduction of infectivity was observed after 6 h exposure. This study provides a practical example of low technology methods which could be utilised to provide safe drinking water in various circumstances.     

Pastoral farmland habitat diversity in south-east Ireland

In this study, habitat surveys were undertaken on 50 grass-based farms in SE Ireland and data digitised onto aerial photography. Additional data i.e. stocking rates, and participation (or otherwise) in the Irish Rural Environment Protection Scheme (REPS) were collected and analysed as possible explanatory variables for farm habitat composition.Results indicated that approximately 14.3% of the land area of sampled farms comprised of semi-natural habitat types, a proportion substantially greater than has been reported for many other European countries. The most frequently recorded semi-natural habitats included, field boundaries, scrub, and deciduous and riparian woodlands.Multivariate analysis of farm habitat configuration showed a strong dichotomy between dairy and non-dairy farming systems. Habitats such as intensively managed grassland and built ground were closely associated with dairy-based enterprises. In contrast, the incidence of other habitat types was associated with non-dairy and/or REPS participating enterprises. The ecological quality of field boundaries as assessed by the Field Boundary Evaluation and Grading System (FBEGS) Index was significantly greater on dairy, compared with dry-stock farms.This dichotomy in farm habitat composition is not reflected within current Agri-Environment (AE) policy. Integration of locally important drivers of habitat diversity into the design and implementation of AE policy, is integral to the successful performance of AE schemes.     

Applying the precautionary principle to consumer household cleaning product development

Hazardous chemicals are pervasive in household disinfectant products. Many ingredients have established associations with acute and chronic human health conditions as well as with environmental damage. Although these associations are suggested but not proven, they are of great concern. This article describes the application of the precautionary principle to the selection of an anti-microbial active ingredient for a botanical disinfectant when significant uncertainty exists around the hazard and risk of traditional disinfectant active ingredients. We show that application of the precautionary principle does not stifle innovation and facilitates a responsible approach to product development.     

建立我国海滩质量标准分级体系的探讨

在参考国内外主要海滩质量标准评价体系的基础上,论文根据我国海滩的具体状况,提出适合我国国情的海滩质量标准体系。标准体系包括自然和社会经济两类共54个因子,对不同开发程度的海滩实行不同的评分标准,最终将海滩分为钻石、金、银、铜及不及格5个等级。论文对山东和福建共6个不同开发程度(开发成熟,低度开发/未开发)的海滩进行了试点应用,结果表明,厦门黄厝得分最高,霞浦大京得分最低。同时解释所提出标准的适用性,并对海滩资源可持续开发利用提出管理对策。     

Random parameter models for accident prediction on two-lane undivided highways in India

Introduction

Generalized linear modeling (GLM), with the assumption of Poisson or negative binomial error structure, has been widely employed in road accident modeling. A number of explanatory variables related to traffic, road geometry, and environment that contribute to accident occurrence have been identified and accident prediction models have been proposed. The accident prediction models reported in literature largely employ the fixed parameter modeling approach, where the magnitude of influence of an explanatory variable is considered to be fixed for any observation in the population. Similar models have been proposed for Indian highways too, which include additional variables representing traffic composition. The mixed traffic on Indian highways comes with a lot of variability within, ranging from difference in vehicle types to variability in driver behavior. This could result in variability in the effect of explanatory variables on accidents across locations. Random parameter models, which can capture some of such variability, are expected to be more appropriate for the Indian situation.

Method

The present study is an attempt to employ random parameter modeling for accident prediction on two-lane undivided rural highways in India. Three years of accident history, from nearly 200 km of highway segments, is used to calibrate and validate the models.

Results

The results of the analysis suggest that the model coefficients for traffic volume, proportion of cars, motorized two-wheelers and trucks in traffic, and driveway density and horizontal and vertical curvatures are randomly distributed across locations.

Conclusions

The paper is concluded with a discussion on modeling results and the limitations of the present study.     

A Bayesian assessment of the effect of highway bypasses in Iowa on crashes and crash rate

Introduction

A common contention is that the construction of highway bypasses negatively impacts the economy of local communities by reducing pass-by traffic for businesses. However, as access to specific business' account records is limited, this impact is difficult to quantify. Another common contention is that bypasses contribute to a reduction in overall crashes in the community and in the surrounding areas. Even though a large number of bypasses have been constructed in the State of Iowa over the past several years, their actual impact in terms of traffic safety has not been quantified.

Objectives

This study seeks answers to the following questions: (a) Are bypasses in Iowa associated with a reduction in crash frequencies and crash rates on the bypassed highway? (b) Do bypasses in Iowa introduce a reduction of overall crash frequencies and rates or do they merely shift crashes from the highways through the communities to the bypasses with no significant overall reduction?

Method

We obtained crash information from the Iowa DOT at 19 sites on which a bypass was constructed sometime during the past 23 years. We also obtained the same information at six sites used as comparison sites on which no bypasses were constructed at least until 2005. We them employed a Bayesian approach to estimating the association between the construction of the bypass and crash rates, while also accounting for other factors.

Results

The construction of bypasses in Iowa is associated with a significant increase in traffic safety both on the main road through town and on the combined main road and bypass roadway.     

Implementing falls prevention research into policy and practice in Australia: past, present and future

Introduction

Falls in older Australians are a significant public health issue with one in three older people falling one or more times each year.

Method

Many fall prevention randomized controlled trials have been conducted in Australia as well as across the world.

Results

The findings of these studies now constitute a substantial evidence base that can provide direction for health and lifestyle interventions for preventing falls in older people. This research evidence has contributed to health policy in Australia to some extent, but is yet to be widely implemented into practice. This opinion piece overviews previous policy initiatives and describes a new Partnership research program funded by the Australian National Health and Medical Research Council (NHMRC), which seeks to further influence health policy and address the ongoing research-practice gap.