There are over 50 SARS-CoV-2 candidate vaccines undergoing Phase II and III clinical trials. Several vaccines have been approved by regulatory authorities and rolled out for use in different countries. Due to concerns of potential teratogenicity or adverse effect on maternal physiology, pregnancy has been a specific exclusion criterion for most vaccine trials with only two trials not excluding pregnant women. Thus, other than limited animal studies, gradually emerging development and reproductive toxicity data, and observational data from vaccine registries, there is a paucity of reliable information to guide recommendations for the safe vaccination of pregnant women. Pregnancy is a risk factor for severe COVID-19, especially in women with comorbidities, resulting in increased rates of preterm birth and maternal morbidity. We discuss the major SARS-CoV-2 vaccines, their mechanisms of action, efficacy, safety profile and possible benefits to the maternal-fetal dyad to create a rational approach towards maternal vaccination while anticipating and mitigating vaccine-related complications. Pregnant women with high exposure risks or co-morbidities predisposing to severe COVID-19 infection should be prioritised for vaccination. Those with risk factors for adverse effects should be counselled accordingly. It is essential to support patient autonomy by shared decision-making involving a risk-benefit discussion with the pregnant woman. 相似文献
The cover image is based on the Original Article Noninvasive prenatal paternity testing by means of SNP-based targeted sequencing by Jacqueline Chor Wing Tam et al., https://doi.org/10.1002/pd.5595 .
Tetraclita squamosa and Tetraclita japonica are common, intertidal barnacles. In Hong Kong, the population dynamics of the two species exhibited spatial and temporal variation on two semi-exposed shores. T. squamosa produced egg masses from May–June and annual settlement and recruitment occurred from June–July. In contrast, settlement and recruitment of T. japonica was sparse from March–May, but intensified in July–October. Mature gonads and egg masses were, however, only present from September–November, suggesting the larvae from the two settlement pulses originated from other locations as well as Hong Kong populations. Settlement intensity and post-recruitment mortality of the two species varied between sites, possibly due to spatial variation in free rock space, physical transport of larvae and abundance of food in the water column.Communicated by T. Ikeda, Hakodate 相似文献