Zellteilung und Zellzyklus

The paper gives a short review of biochemical and genetic analyses of the eukaryotic cell cycle and cell division. Emphasis is placed on the interrelationship of macromolecular syntheses during chromosome replication, the possible involvement of protein phosphorylation in chromosome condensation, the function of contractile proteins in mitosis and cytokinesis and on mechanisms which trigger cell proliferation.     

Ökobilanzen — Fortschrittsbericht

With efforts made by the International Standard Organization (ISO) to standardize life cycle assessment procedures, considerable progress could be reached in the year 1996. Standardizations of the “Principles and Framework” (ISO 14040) and the “Inventory” (ISO 14041) will come into force in 1997. Drafts of the “Impact Assessment” and “Interpretation” were specified in 1996. The case studies presented here give an overview on different approaches of “Impact Assessment” and “Interpretation”. The main advantage of an ISO-standard will not be the standardization of the impact assessment approach itself. More important than merely the outcome of a life cycle assessment is to assign additional information on the reliability of the results in respect to the formulation of questions.     

Ultrasound screening for chromosomal anomalies in the first trimester of pregnancy

For the last 6 years, sonographic signs for excessive fluid accumulation in the backs of 10- to 12-week-old fetuses have been looked for prior to transabdominal chorionic biopsy. In 1400 pregnancies, subsequent karyotype analyses revealed 28 cases of Down syndrome. In 15 ( = 54 per cent), a large fluid cushion over most of the back had been documented at the time of biopsy. Only a few chromosomally normal fetuses with the same peculiarity were observed. The cushion was also present in fetuses with trisomies 18 and 13 , and in Turner syndrome. Systematic first-trimester screening for nuchal fluid accumulation seems to be a recommended method for the detection of Down syndrome and other chromosome anomalies in young pregnant women at low risk. It compares favourably with current methods of maternal serum screening performed at 16–18 weeks which require a higher number of invasive procedures.     

Reconstruction of palaeosalinity using carbon isotopes and benthic associations: a comparison

Carbon and oxygen isotopes were determined on 40 recrystallized shells of Late Jurassic bivalves from the Lusitanian Basin of Portugal. In contrast with the oxygen isotopes, which exhibited considerable diagenetic distortion, the carbon isotopes are thought to preserve a record of the salinity of the Jurassic marginal marine seas in which these bivalves lived. The reconstructed palaeosalinities range from 35‰ (euhaline) to 5‰ (oligohaline). Comparing these values with the palaeosalinity reconstructed from a palaeoecological analysis of 17 stratigraphic levels within the basin, the independently derived values agree in most cases. Strongly differing values are explained as being due to biotic factors and to diagenetic distortion of the isotopic signal; they are less likely to be due to small-scale time-averaging or insufficient microstratigraphic sampling. On the whole, the carbon isotope analyses are thought to produce reasonable palaeosalinity values, although data from infaunal, originally aragonitic bivalves appear to be less reliable than those from epifaunal bivalves with a predominantly or exclusively calcitic shell. As diagenetic alteration of the carbon isotope signal is, however, unpredictable and biotic effects on the isotopic composition are insufficiently known, palaeosalinity reconstructions based on stable isotope data should be supported by palaeoecological data.