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821.
Chensheng Lu Teresa Rodriguez Anamai Thiravirojana-Thetkathuek Melanie Pearson 《毒物与环境化学》2013,95(2):315-325
The objective of this study was to determine the feasibility of using salivary biomarkers to assess chlorpyrifos exposure using data collected from laboratory controlled animal study, as well as from farmers in Thailand and Nicaragua who applied chlorpyrifos in the field. Time-matched saliva and arterial blood samples were collected from rats and adult agricultural workers, while spot saliva samples were collected from children. Specimen samples were analyzed for chlorpyrifos using a commercially available enzyme-linked immunosorbent assay. The results from both animal and farmer studies show that chlorpyrifos is excreted into saliva. Nevertheless, salivary excretion of chlorpyrifos seems to differ from other pesticides, as evidenced by the lack of correspondence of chlorpyrifos levels between saliva and plasma samples. The lower chlorpyrifos concentrations in saliva collected from rats, and from farmers and their children, may have resulted from the rapid hydrolysis of chlorpyrifos during the intracellular passive diffusion in the salivary gland. In conclusion, chlorpyrifos is excreted into saliva; however, the majority of chlorpyrifos that is excreted in saliva may have been metabolized due to base-dependent hydrolysis. Because of this finding, it was hypothesized that it would be ideal to measure its metabolite, 3,5,6-trichloropyridinol, in saliva as the biomarker for chlorpyrifos exposure. 相似文献
822.
Small amounts of bivalent cations, usually provided by Mg2+, are in the living cell necessary for the biological activity of t‐RNA as these bivalent cations influence the tertiary and secondary structure of this globular polynucleotide. In context with the discussed possibility of carcinogenic actions of ingested Cd it is of particular interest to check whether there exist specific strong interactions of this toxic heavy metal with nucleic acids. Therefore, the binding of the toxic heavy metal ion Cd2+ and the essential heavy metal ion Mn2+ to t‐RNA and for comparison to DNA and the polynucleotides poly‐U, poly‐A and poly‐A‐poly‐U has been studied. Free metal ion concentrations have been determined by differential pulse polararography. Association constants and the number of binding sites have been evaluated by the Scatchard method and alternatively according to a simple electrostatic model of the polyelectrolytes. With the Scatchard method for t‐RNA and all polynucleotides with helical structure two different binding sites of different strength are observed. Those with higher association constants are assigned to the helical parts of t‐RNA. Interaction sites with low association constants correspond to the parts with no ordered tertiary structure, as their exclusive occurrence for poly‐U, having a completely stochastic coil structure, reflects. The values of the association constants for the stronger and weaker association sites are in the respective polynucleotides for both investigated bivalent metal ions of comparable magnitude. This emphasizes that the interaction is essentially of electrostatic nature and depends primarily on the charge of the interacting species. Thus the specific strong interaction of Cd by the intercalation into the tertiary structure of nucleic acids or by chelation of their base units can be ruled out as one possibility for carcinogenity of Cd. Moreover, under physiological conditions the high excess of competitive Mg2+ will suppress the interaction of Cd based on electrostatic forces. 相似文献
823.
The synthesis of several 6‐n‐propyl‐5‐arylazo‐2‐thiouracil derivatives was achieved. The antithyroid activity of these derivatives has been determined using iodine‐125‐thiocyanate discharge technique in rats, and 6‐n‐propyl‐2‐thiouracil (PTU) as a standard. None of the 5‐arylazo‐2‐thiouracil analogs showed antithyroid activity as compared to PTU. The structure‐activity relationships (SAR) of position 5 in the PTU molecule and the requirements for better binding to the proposed receptor are discussed. 相似文献
824.
Zuhair R. Zahid Zuhair S. Al‐Hakkak Abdul Hussain H. Kadhim Elias A. Elias Iman S. Al‐Jumaily 《毒物与环境化学》2013,95(2-3):131-136
It has been repeatedly stressed that the biological effectiveness of chromium depends entirely on its oxidation state. The present work compares the histological effects of ingested trivalent and hexavalent chromium compounds on the mouse testes. The results showed comparable data of food consumption and gain in body weight. Both compounds produced ambiguous levels of degeneration in the outmost cellular layers of a number of seminiferous tubules, reduced the number of spermatogonia per tubule and the sperm count, and caused significant increases in the percentage of morphologically abnormal sperms. Generally, all these effects were more pronounced in animals which ingested the hexavalent chromium. 相似文献
825.
C. Cebrián E. S. Andreu M. D. Ferrando A. Fernández‐Casalderrey M. Gamón 《毒物与环境化学》2013,95(1):321-327
Routine applications of organophosphate pesticides may adversely affect many nontarget organisms. Static toxicities in mature crayfish Procambarus clarkii were determined, in laboratory, for two organophosphate insecticides using 24, 48, 72 and 96‐h static tests. Three groups of 10 crayfish were exposed to 0.75 to 6 ppm for Trichlorfon and 0.2 to 0.9 ppm for Methidathion. The 24 to 96‐h LC50 values for Trichlorfon and Methidathion were from 5.14–0.99 ppm and 0.73–0.28 ppm respectively. Studies of degradation of Methidathion and Trichlorfon have been made using 1 ppm for Methidathion and 0.1 ppm for Trichlorfon. Both insecticides were degradated gradually until 96‐h. Results show that Methidathion is more toxic to P. clarkii in our medium and degradation of both pesticides is similar. 相似文献
826.
An accurate and reproducible method for the analysis of flurazepam hydrochloride in pharmaceutical preparations has been described. A simple and rapid isocratic HPLC elution method was employed which requires about 15 minutes to be performed. The percentage mean recovery of flurazepam hydrochloride in Dalmane capsules was found to be 100.67% + 1.23% of the declared amount 相似文献
827.
Quantitative structure‐activity relationships of hydrophobic organic chemicals were studied based on equations we established. Results showed that observed toxicity of hydrophobic organic chemicals were correlated to two physical‐chemical parameters: reaction equilibrium constant of target molecule‐organic chemical; octanol/water partition coefficient. Regression results showed that the molecular connectivity index of first‐order was an ideal parameter instead of the equilibrium constant. Good relationships between toxicity data and the two parameters were found for three aquatic organisms with a wide range of chemicals. 相似文献
828.
829.
This research work was performed to evaluate ozonation and granular activated carbon adsorption processes from the view‐point of controlling the formation of disinfection by products (DBPs). Both the humic acid and raw water were first preozonated and then adsorbed on the activated carbon to assess the potency for removal of total organic carbon (TOC) and DBPs. The disinfection by‐product including THMs and HAAs, in principle, can be successfully removed through a use of the ozonation and granular activated carbon (GAC) adsorption processes. However, in practice dealing with the raw water, it is necessary to introduce the pilot‐plant to obtain the design and operation guidelines for the water treatment plant through the ICA (Instrumentation Control and Automation) program in our future research work. 相似文献
830.
M. E. Alvarez Piñeiro M. A. Lage Yusty J. Simal Lozano S. T. Carril Gonzalez‐Barros 《毒物与环境化学》2013,95(1-4):31-36
PCB and PCT residues were measured in free‐living (FM) and cultivated mussels (CM) from ten sites in Galicia by gas chromatography with electron capture detector and capillary column. The level of PCB1260 and PCT5460 in FMs increases going from Muros‐Noya to Vigo estuarine bay. There was a trend of increase from north to south. 相似文献