The ability to monitor hydrogen peroxide (H2O2) in aqueous smoke extracts will advance our understanding of the relationship between cigarette smoke-induced oxidative stress, inflammation, and disease and help elucidate the pathways by which the various smoke constituents exert their pathogenic effects. We have demonstrated, for the first time, the measurement of H2O2 production from cigarette smoke without prior separation of the sample. Cigarettes were tested on a commercial smoking machine, such that the whole smoke or gas vapor phase was bubbled through phosphate buffered saline solution at pH 7.4. Aliquots of these solutions were analyzed using an Amplex Red/horseradish peroxidase fluorimetric assay that required only a 2 minute incubation time, facilitating the rapid, facile collection of data. Catalase was used to demonstrate the selectivity and specificity of the assay for H2O2 in the complex smoke matrix. We measured approximately 7-8 microM H2O2 from two reference cigarettes (i.e., 1R4F and 2R4F). We also observed 9x more H2O2 from whole smoke bubbled samples compared to the gas vapor phase, indicating that the major constituent(s) responsible for H2O2 formation reside in the particulate phase of cigarette smoke. Aqueous solutions of hydroquinone and catechol, both of which are particulate phase constituents of cigarette smoke, generated no H2O2 even though they are free radical precursors involved in the production of reactive oxygen species in the smoke matrix. 相似文献
ABSTRACT: The purpose of this paper is to describe a land use and environmental planning model. Map overlays were used for analyzing and aggregating economic, social, and environmental data. Various land use categories were evaluated using a numerical scoring system. These scores were then used to assist in the development of land use regulations in a coastal county in South Carolina. 相似文献
Objective: Statistics indicate that employees commuting or traveling as part of their work are overrepresented in workplace injury and death. Despite this, many organizations are unaware of the factors within their organizations that are likely to influence potential reductions in work-related road traffic injury.
Methods: This article presents a multilevel conceptual framework that identifies health investment as the central feature in reducing work-related road traffic injury. Within this framework, we explore factors operating at the individual driver, workgroup supervisor, and organizational senior management levels that create a mutually reinforcing system of safety.
Results: The health investment framework identifies key factors at the senior manager, supervisor, and driver levels to cultivating a safe working environment. These factors are high-performance workplace systems, leader–member exchange and autonomy, trust and empowerment, respectively. The framework demonstrates the important interactions between these factors and how they create a self-sustaining organizational safety system.
Conclusions: The framework aims to provide insight into the future development of interventions that are strategically aligned with the organization and target elements that facilitate and enhance driver safety and ultimately reduce work-related road traffic injury and death. 相似文献
McMahon, Tyler G. and Mark Griffin Smith, 2012. The Arkansas Valley “Super Ditch”— An Analysis of Potential Economic Impacts. Journal of the American Water Resources Association (JAWRA) 00(0):000‐000. 1‐12. DOI: 10.1111/jawr.12005 Abstract: In Colorado’s Arkansas River basin, urban growth and harsh farming conditions have resulted in water transfers from agricultural to urban uses. Several studies have shown that these transfers have significant secondary economic impacts associated with the removal of irrigated land from production. In response, new methods of sharing water are being developed to allow water transfers that benefit both farm and urban economies, compared with previous permanent transfers that negatively impacted surrounding farm communities. One such project currently under development is the Arkansas Valley “Super Ditch,” which is a rotational crop fallowing plan based on long‐term water leasing designed to provide an annual supply of 25,000 acre‐feet of water (31.6 Mm3). This article analyzes the net benefits of implementing the “Super Ditch” for both the farmers and the surrounding community. 相似文献
To prepare for the 2008 Olympic Games, China adopted a number of radical measures to improve air quality. Using the officially reported air pollution index (API) from 2000 to 2009, we show that these measures improved the API of Beijing during and a little after the Games, but a significant proportion of the effect faded away by October 2009. For comparison, we also analyze an objective and indirect measure of air quality at a high spatial resolution – aerosol optimal depth (AOD), derived using the data from NASA satellites. The AOD analysis confirms the real but temporary improvement in air quality, it also shows a significant correlation between air quality improvement and the timing and location of plant closure and traffic control. These results suggest that it is possible to achieve real environmental improvement via stringent policy interventions, but for how long the effects of these interventions will last will largely depend on the continuation of the interventions. 相似文献
ABSTRACT: The ground water in the Tucson basin is being drawn faster than it is replenished by nature. The water table is falling, giving rise to several conflicts between water users in the basin. At present, several lawsuits are in progress, including an action by the Papago Tribe against some of the major water users in the basin. Largely because of these difficulties, the State Legislature has established a commission to make proposals for the reform of Arizona's ground water law. The pattern of water use in the basin will undoubtedly be changed by the outcome of the present litigation and the coming reform of Arizona's ground water law. This paper describes how water use in the basin might be affected by changes in the availability of water and gives an account of the effects that these changes in water use could have on the region's economy. The paper concludes that the water problems of the Tucson basin will have little effect on the region at large and that these problems are simply a matter for the Indians and the other water users in the basin to sort out amongst themselves. 相似文献
ABSTRACT: Infiltration processes at the plot scale are often described and modeled using a single effective hydraulic conductivity (Kg) value. This can lead to errors in runoff and erosion prediction. An integrated field measurement and modeling study was conducted to evaluate: (1) the relationship among rainfall intensity, spatially variable soil and vegetation characteristics, and infiltration processes; and (2) how this relationship could be modeled using Green and Ampt and a spatially distributed hydrologic model. Experiments were conducted using a newly developed variable intensity rainfall simulator on 2 m by 6 m plots in a rangeland watershed in southeastern Arizona. Rainfall application rates varied between 50 and 200 mm/hr. Results of the rainfall simulator experiments showed that the observed hydrologic response changed with changes in rainfall intensity and that the response varied with antecedent moisture condition. A distributed process based hydrologic simulation model was used to model the plots at different levels of hydrologic complexity. The measurement and simulation model results show that the rainfall runoff relationship cannot be accurately described or modeled using a single Kg value at the plot scale. Multi‐plane model configurations with infiltration parameters based on soil and plot characteristics resulted in a significant improvement over single‐plane configurations. 相似文献