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Daniella Rogerson Anna Alkelai Jessica Giordano Madhulatha Pantrangi Meng-Chang Hsiao Chia-Ling Nhan-Chang Joshua E. Motelow Vimla Aggarwal David Goldstein Ron Wapner Carrie J. Shawber 《黑龙江环境通报》2023,43(6):703-716
Objective
Congenital lymphatic anomalies (LAs) arise due to defects in lymphatic development and often present in utero as pleural effusion, chylothorax, nuchal and soft tissue edema, ascites, or hydrops. Many LAs are caused by single nucleotide variants, which are not detected on routine prenatal testing.Methods
Demographic data were compared between two subcohorts, those with clinically significant fetal edema (CSFE) and isolated fetal edema. A targeted variant analysis of LA genes was performed using American College of Medical Genetics criteria on whole exome sequencing (WES) data generated for 71 fetal edema cases who remained undiagnosed after standard workup.Results
CSFE cases had poor outcomes, including preterm delivery, demise, and maternal preeclampsia. Pathogenic and likely pathogenic variants were identified in 7% (5/71) of cases, including variants in RASopathy genes, RASA1, SOS1, PTPN11, and a novel PIEZO1 variant. Variants of uncertain significance (VOUS) were identified in 45% (32/71) of cases. In CSFEs, VOUS were found in CELSR1, EPHB4, TIE1, PIEZO1, ITGA9, RASopathy genes, SOS1, SOS2, and RAF1.Conclusions
WES identified pathogenic and likely pathogenic variants and VOUS in LA genes in 51% of fetal edema cases, supporting WES and expanded hydrops panels in cases of idiopathic fetal hydrops and fluid collections. 相似文献83.
84.
A. I. Fiaschi D. Cerretani E. Battisti L. Bianciardi N. Giordano A. Albanese 《The Environmentalist》2009,29(2):200-204
Osteoarthritis (OA) is the most common joint disorder, associated with loss of articular cartilage, osteophyte formation,
subchodral bone change, synovitis and characterized by chronic and often disabling pain and stiffness of one or more joints.
The pathogenesis of the disease is complex and still debated, even if recent studies have shown that reactive oxygen species
may participate in the initiation and progression of OA. Moreover, it is known that pulsed electromagnetic fields are useful
in the OA treatment, owing to their analgesic and anti-inflammatory properties. This work evaluated lipid peroxidation, glutathione,
and ascorbic acid levels in patients with OA of spine, before and after the application of a new electromagnetic system, the
TAMMEF (Therapeutic Application of a Musically Modulated Electromagnetic Field) system. In TAMMEF system, the extremely low
frequencies electromagnetic field is piloted by a musical signal and its parameters (frequency, intensity, waveform) are modified
in time, randomly varying within the respective ranges: so all possible codes can occur during a single application. Twenty
patients affected by OA of spine and 20 healthy subjects were enrolled in this study. Plasma levels of ascorbic acid (AA),
glutathione (GSH) and malondialdehyde (MDA) (as index of lipid peroxidation) were determined in patients and controls, before
the beginning of treatment (first day of therapy) and at the end of cycle. All patients underwent a cycle of 10 daily sessions
of 30 min each. Our study showed a significant increase of MDA level and a significant decrease of both AA and GSH levels
in patients with OA compared to control group. These findings support the role of oxidative stress in the pathogenesis of
OA. After TAMMEF treatment in the OA group, analysis revealed a significant decrease in plasma MDA and AA levels (P < 0.05 and P < 0.01, respectively), no significant difference in GSH levels. Reduction in MDA level could be due to the decreased generation
of reactive oxygen species and/or to the increased detoxification activity mediated by GSH. No significant difference in GSH
levels, evidenced in OA patients after TAMMEF treatment, could be due to effect sparing of AA on GSH. Furthermore, a beneficial
symptomatic effect was observed in all patients. 相似文献
85.
Specchiulli Antonietta Scirocco Tommaso D’Adamo Raffaele Cilenti Lucrezia Fabbrocini Adele Cassin Daniele Penna Pierluigi Renzi Monia Bastianoni Simone 《Journal of Coastal Conservation》2016,20(5):363-374
Phytoplankton and benthic vegetation biomass undergoes spatial-temporal changes in relation to their life cycle, but also to meteorological conditions, physical-chemical variables, organic input and internal dynamism. The main aim of this work was to observe the effect of all environmental variables on the vegetative dynamic process in a protected zone of a Mediterranean costal lagoon (Lesina lagoon, SE Italy). Seven samplings were performed from 2010 to 2012 at 30 sites for nutrient and chlorophyll analyses, while TOC measurements and wet biomass evaluation were performed at 10 sites. Temperature, salinity and oxygen saturation were also measured by multiparametric probe and a visual census for vegetation was performed. Sites close to freshwater inflow were characterized by lower temperature and salinity, and high nitrate, with maxima of 191.05 μM in May 2010 and more than 250 μM in October 2010. Silicates drastically decreased from May 2010 (87.57 μM) to July 2010 (6.15 μM) and increased again in October (74.99 μM). Chl a concentrations were not on average higher than 6 mg m?3, but peaks of 20 mg m?3 were observed during May 2011 and May 2012. Benthic vegetation wet biomass collected in 2010 was approximately twice that collected in 2012, with a maximum of 27,554 g m?2 and a dominance of macroalgae (70 % in May 2010 and 40 % in August 2010). During period 2010, a simultaneous and drastic decreasing of both mean values of wet biomass and chl a was observed from May to October 2010. During period 2012 a shift of vegetation biomass was shown from May (phytoplankton prevalence) to August 2012, with angiosperm prevalence (more than 30 %). 相似文献
86.
The accumulation ability of the major elements sulphur, nitrogen and carbon by the moss Sphagnum capillifolium (Ehrh.) Hedw. and the lichen Pseudevernia furfuracea (L.) Zopf exposed in bags in Naples urban area,was investigated. Bags were exposed at the beginning of July 1999 and gathered in two subsequent moments: at the end of the dry season (after 10 weeks of exposure) and during the wet season (after 17 weeks of exposure), to include the effects of rainy conditions. Sulphur and N content of the lichen increased all over the exposure period, while the level of C did not change significantly either after 10 or 17 weeks of exposition. For the moss the S accumulation was limited to the dry period of exposure, whereas N and C content decreased with exposure. Results, in contrast with those obtained in a previous study on trace elements bioaccumulation [Adamo et al., Environmental Pollution, (2003) 122, 91-103], suggest that accumulation of gaseous pollutants is strongly influenced by biomonitor vitality and that lichen bags are a more reliable and effective tool for monitoring S, N and C atmospheric depositions in urban areas compared to moss bags, because of greater lichen resistance to dry and stressing conditions of urban environment. 相似文献
87.
Craig E. Divine Ronald L. Clemmer Azra Bilgin Jeff Clonts Thomas J. Giordano 《Journal of the American Water Resources Association》2007,43(4):864-874
Abstract: For most wastewater discharges to streams, the effluent creates a plume that becomes less distinct as it mixes with the receiving water. Constant‐discharge tracer studies were used to characterize the plume or physical mixing zone (PMZ) at two similar transition terrain streams. At both sites, the laterally unmixed PMZs did not extend across the entire stream and mixing occurred relatively quickly. The observed plumes were significantly smaller than the regulatory mixing zone (RMZ) allowed by the State of Colorado. At Site 1 mixing occurred within a much shorter distance due to the presence of a riffle zone located a few meters downstream of the discharge point. Interpretation of field data with an analytical model suggests that the effective transverse dispersion coefficient (kz) for the riffle zone at Site 1 (~1 m2/s) was significantly higher than the average value over the longer nonriffle section at Site 2 (~0.01 m2/s). These results imply that to achieve the fastest mixing in transition terrain streams, thereby minimizing the size of the PMZ, discharge outfalls should be located upstream and close to riffle zones. 相似文献
88.
Motta Oriana Pironti Concetta Ricciardi Maria Rostagno Chiara Bolzacchini Ezio Ferrero Luca Cucciniello Raffaele Proto Antonio 《Environmental science and pollution research international》2022,29(20):29391-29398
Environmental Science and Pollution Research - The most important parameter to obtain an appropriate preservation condition of museum environments concerns the indoor air quality. The exposure of... 相似文献
89.
Pironti Concetta Ricciardi Maria Proto Antonio Cucciniello Raffaele Fiorentino Antonino Fiorillo Rosa Motta Oriana 《Environmental science and pollution research international》2022,29(20):29385-29390
Environmental Science and Pollution Research - In this study, we evaluated indoor air quality to highlight the effects of environmental pollution in the field of cultural heritage. In particular,... 相似文献