First-trimester free beta (hCG) screening for Down syndrome

Maternal serum free beta (hCG) levels are elevated (median 2·20 MOM) in the first trimester of pregnancy in 38 Down syndrome cases as compared with appropriate controls. This observation may form the basis for its use as a marker in screening for Down syndrome in the first trimester. Altered levels of the free beta analyte are observed in pregnancy conditions or complications other than Down syndrome.     

Rapid detection of numerical aberrations of chromosomes 13, 18 and 21 in chorionic mesenchymal cells

We have devised and evaluated a rapid screening method for the detection of numerical aberrations of chromosomes13, 18 and 21 in chorionic villus cells. We used non-radioactive in situ hybridization (ISH) with three chromosome-specific probes on overnight-attached mesenchymal cells from chorionic villi. A blind study was performed of 47 karyotypically normal samples, one triploid sample, two samples trisomic for chromosome 21, and two samples from a fetus with putative mosaicism (46/47, +21). All samples were hybridized with the chromosome 18- and 21-specific probes. Thirty samples were additionally hybridized with the chromosome 13-specific probe. The test could be completed within 3-4 days of sampling. In samples disomic with respect to the probed chromosomes, an average of 2 per cent (range 0-9 per cent) had three hybridization signals. By contrast, in the samples trisomic for the probed chromosome(s), 57 per cent (chromosome 13), 51 per cent (chromosome 18), and an average of 74 per cent (55-86 per cent) (chromosome 21) of the nuclei exhibited three signals. In the putative mosaic samples, the number of nuclei with three chromosome 21-specific signals ranged from 41 to 69 per cent. We conclude that this technique rapidly and clearly distinguishes between normal and trisomic/triploid samples, and consequently may be of use in future prenatal diagnosis.     

污染环境的刑事责任问题探讨

根据一些发达国家的法律实践和我国环境保护工作的实际需要,探讨了对环境造成严重恶果的行为,应设立“污染环境罪”来调整人们行为的最后法律手段的必要性,并就污染环境罪的基本特征及与其它法律责任的区别作了分析和阐述,提出在我国刑法中应专条补充设立“污染环境罪”规定的建议。     

Mine closure legislation in Indonesia: The role of mineral industry involvement

Major mining companies have recently embraced the sustainable development paradigm, in seeking to improve their competitiveness and increase shareholder returns. Successful mine closure is one important element of this process. Improved performance in this area is essential if surrounding communities are to see mining companies as responsible corporate and social partners.
In Indonesia, the new approach has coincided with the development of specific mine closure legislation. To facilitate the legislation, a consortium of mining companies joined to form the Industry Mine Closure Steering Committee. This Committee has lobbied the Government, actively negotiating to incorporate sustainable development ideals and practices into the new legislation. The Committee's aim has been to foster continued development of the mining industry, while taking account of variation in environmental, social and community conditions. In describing the process, this article seeks to provide guidance for the development of mine closure legislation in other nations.     

土地利用变化驱动下的上海市区水灾灾情模拟

对上海市区近50年来的土地利用结构变化进行了重建，并计算了由土地利用变化引起的上海市区水位变化量。以特定的1962年水灾为参照，模拟在同等雨强情况下，由土地利用结构变化和地面沉降引起的淹没范围的变化以及由此带来的水灾损失的变化。结果表明，在49mm／d降水条件下，由于土地利用的变化，使2001年的径流系数比1950年增大了34．0％，2001年的水位比1950年增高了45．9％；2001年的水灾灾情为1950年的1．0629倍；即使在目前千年一遇的防洪标准下，亦可造成相当于2001年地均GDP值0．088％(约为4．5亿元人民币)的损失，这是1991年相应数值的220倍。     

火灾烟气中有毒气体的体积分数分布与危害

研究火灾烟气的成分与其体积分数分布是火灾科学的一项重要内容。为了更好地研究建筑火灾烟气的释放过程并为建筑材料评价提供依据，采用文献综述的方法论述了建筑火灾烟气的主要有毒成分、体积分数范围(即浓度范围)与危险含量(即危险浓度)，还介绍了常用的烟气分析方法，说明了对火灾烟气的产生机理和火灾烟气成分的检测方法等还需要进行深入的研究。     

论环境安全视角下的我国灾害防治法制建设

当今社会面临的日趋严重且类型众多的灾害，构成了对生态环境安全的巨大威胁，为此各国都在致力于发挥法制手段在灾害防治中的不可替代的作用。我国是个多灾国家，在减灾法治方面虽已取得了一定成就，但总体上还比较薄弱，因此进一步加强该领域的法制建设十分重要。从我国环境安全保障角度及与国际经验的比较来看，完善我国减灾法制建设的基本工作涉及到减灾法制体系的理论研究、立法模式的选择及其充实方向、行政体制的理顺及执法司法功能的强化等多个方面。     

The Cotingo Dam as a test of Brazil's system for evaluating proposed developments in Amazonia

The proposed Cotingo Dam in Brazil's far northern state of Roraima is examined with the objective of drawing lessons for Brazil's system of evaluating environmental, social, and financial consequences of development decisions. The Cotingo Dam illustrates the difficulty of translating into practice the principles of economic and environmental assessment. Examination of the financial arguments for the Cotingo Dam indicates that justifications in this sphere are insufficient to explain why the project is favored over other alternatives and points to political factors as the best explanation of the project's high priority. Strong pressure from political and entrepreneurial interest groups almost invariably dominates decision making in Amazonia. The analysis indicates the inherent tendency of the present system to produce decisions in favor of large construction projects at the expense of the environment and local peoples. The requirements intended to assure proper weight for these concerns, such as the report on environmental impacts (RIMA) and the public hearing, fail to serve this role. Cotingo also provides a test case for constitutional protections restricting construction of dams in indigenous lands.