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Brooke E. Willborg Eniola R. Ibirogba Ayssa Teles Abrao Trad Lourenço Sbragia Dean Potter Rodrigo Ruano 《黑龙江环境通报》2021,41(1):159-176
We conducted a comprehensive evidence-based review on the epidemiology and current standard of care of gastroschisis management as well as the pathophysiology, rationale and feasibility of fetal therapy as a viable alternative. Gastroschisis is a periumbilical abdominal wall defect characterized by abdominal viscera herniation in utero. It affects 4 in 10 000 live births, but the prevalence has steadily increased in recent years. Gastroschisis is typically diagnosed on routine second-trimester ultrasound. The overall prognosis is favorable, but complex gastroschisis, which accounts for about 10% to 15% of cases, is associated with a higher mortality, significant disease burden and higher healthcare costs due to long- and short-term complications. The current standard of care has yet to be established but generally involves continued fetal surveillance and multidisciplinary perinatal care. Postnatal surgical repair is achieved with primary closure, staged silo closure or sutureless repair. Experimental animal studies have demonstrated the feasibility of in utero closure, antiinflammatory therapy and prenatal regenerative therapy. However, reports of early preterm delivery and amnioinfusion trials have failed to show any benefit in humans. Further experimental studies and human trials are necessary to demonstrate the potential benefit of fetal therapy in gastroschisis. 相似文献
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Animal lifespans range from a few days to many decades, and this life history diversity is especially pronounced in ants.
Queens can live for decades. Males, in contrast, are often assumed to act as ephemeral sperm delivery vessels that die after
a brief mating flight—a view developed from studies of lekking species in temperate habitats. In a tropical ant assemblage,
we found that males can live days to months outside the nest, a trait hypothesized to be associated with female calling, another
common mating system. We combined feeding experiments with respirometry to show that lifespan can be enhanced over 3 months
by feeding outside the nest. In one focal female calling species, Ectatomma ruidum, feeding enhanced male lifespan, but not sperm content. Extended lifespans outside the nest suggest stronger than expected
selection on premating traits of male ants, although the ways these traits shape male mating success remain poorly understood. 相似文献
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