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131.
Alex H.S. Chik Melissa B. Glier Mark Servos Chand S. Mangat Xiao-Li Pang Yuanyuan Qiu Patrick M. DAoust Jean-Baptiste Burnet Robert Delatoll Sarah Dorner Qiudi Geng John P. Giesy Robert Mike McKay Michael R. Mulvey Natalie Prystajecky Nivetha Srikanthan Yuwei Xie Bernadette Conant Steve E. Hrudey 《环境科学学报(英文版)》2021,33(9):218-229
132.
Sedeño-Díaz Jacinto Elías López-López Eugenia Rodríguez-Romero A. Joseph Leos Karla Fierro Martínez Melissa Tiburcio Sánchez Oscar Emiliano Escobar 《Environmental science and pollution research international》2022,29(41):61630-61642
Environmental Science and Pollution Research - Qanats in the aquifer of the Tehuacán Valley (Mexico) represent an ancient way of using groundwater that is still practiced today. They are used... 相似文献
133.
Malpuech syndrome (MS) is a rare autosomal recessive syndrome featuring pre- and post-natal growth deficiency, mental retardation, facial dysmorphism, cleft lip and palate (typically midline or bilateral), caudal appendage, renal malformations and male genital abnormalities. A prenatal diagnosis of MS was made in this fetus based on the family history and a combination of conventional and 3D prenatal ultrasound findings. The family were consanguineous with an affected first child. Prenatal ultrasound in the second pregnancy demonstrated bilateral cleft lip and palate in association with intrauterine growth retardation on serial prenatal ultrasound scans. Dysmorphic facial features and a small penis consistent with the diagnosis were confirmed on 3D scanning. Post-natal examination of the neonate confirmed the diagnosis of MS. To the best of our knowledge, this is the first prenatal diagnosis of this syndrome. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
134.
Nicholas Lench Angela Barrett Sarah Fielding Fiona McKay Melissa Hill Lucy Jenkins Helen White Lyn S. Chitty 《黑龙江环境通报》2013,33(6):555-562
Recently, we have witnessed the rapid translation into clinical practice of non-invasive prenatal testing for the common aneuploidies, most notably within the United States and China. This represents a lucrative market with testing being driven by companies developing and offering their services. These tests are currently aimed at women with high/medium-risk pregnancies identified by serum screening and/or ultrasound scanning. Uptake has been impressive, albeit limited to the commercial sector. However, non-invasive prenatal diagnosis (NIPD) for single-gene disorders has attracted less interest, no doubt because this represents a much smaller market opportunity and in the majority of cases has to be provided on a bespoke, patient or disease-specific basis. The methods and workflows are labour-intensive and not readily scalable. Nonetheless, there exists a significant need for NIPD of single-gene disorders, and the continuing advances in technology and data analysis should facilitate the expansion of the NIPD test repertoire. Here, we review the progress that has been made to date, the different methods and platform technologies, the technical challenges, and assess how new developments may be applied to extend testing to a wider range of genetic disorders. © 2013 John Wiley & Sons, Ltd. 相似文献
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138.
Eleanor Harding Jennifer Hammond Lyn S. Chitty Melissa Hill Celine Lewis 《黑龙江环境通报》2020,40(8):1028-1039
Background
Tests in pregnancy such as chromosomal microarray analysis and exome sequencing are increasing diagnostic yield for fetal structural anomalies, but have greater potential to result in uncertain findings. This systematic review investigated the experiences of prospective parents about receiving uncertain results from these tests.Methods
A systematic search of three electronic databases was conducted. Data extraction was performed for studies that met the eligibility and quality criteria. Results were synthesised following the principles of thematic analysis.Results
Fourteen studies (10 qualitative, 4 quantitative) were included. Findings were grouped into three overarching themes. Sources of uncertainty included the testing procedure, the diagnosis and prognosis, and health professionals' own uncertainty. The clinical impact of the uncertainty included parents struggling to make clinical decisions with the information available, the emotional impact included decisional-regret, shock, worry and feeling overwhelmed. To manage the uncertainty, parents sought support from healthcare professionals, friends, family, the internet and other parents as well as remaining hopeful.Conclusions
Prospective parents experience a myriad of uncertainties in the prenatal setting, which must be handled sensitively. Future research should explore optimal ways of managing uncertainty to minimise harm. Recommendations are made for discussing uncertainty during pre- and post-test counseling. 相似文献139.
Managing climate change risks in New York City’s water system: assessment and adaptation planning 总被引:4,自引:0,他引:4
Cynthia Rosenzweig David C. Major Kate Demong Christina Stanton Radley Horton Melissa Stults 《Mitigation and Adaptation Strategies for Global Change》2007,12(8):1391-1409
Managing risk by adapting long-lived infrastructure to the effects of climate change must become a regular part of planning
for water supply, sewer, wastewater treatment, and other urban infrastructure during this century. The New York City Department
of Environmental Protection (NYCDEP), the agency responsible for managing New York City’s (NYC) water supply, sewer, and wastewater
treatment systems, has developed a climate risk management framework through its Climate Change Task Force, a government-university
collaborative effort. Its purpose is to ensure that NYCDEP’s strategic and capital planning take into account the potential
risks of climate change—sea-level rise, higher temperature, increases in extreme events, changes in drought and flood frequency
and intensity, and changing precipitation patterns—on NYC’s water systems. This approach will enable NYCDEP and other agencies
to incorporate adaptations to the risks of climate change into their management, investment, and policy decisions over the
long term as a regular part of their planning activities. The framework includes a 9-step Adaptation Assessment procedure.
Potential climate change adaptations are divided into management, infrastructure, and policy categories, and are assessed
by their relevance in terms of climate change time-frame (immediate, medium, and long term), the capital cycle, costs, and
other risks. The approach focuses on the water supply, sewer, and wastewater treatment systems of NYC, but has wide application
for other urban areas, especially those in coastal locations. 相似文献
140.
Denise M. Cutillo MS Elizabeth A. Hammond Suzanne L. Reeser Melissa A. Kershner Barbara Lukin Lynn Godmilow Alan E. Donnenfeld 《黑龙江环境通报》1994,14(5):327-332
Prenatal diagnosis choices were reviewed in 473 women who presented for genetic counselling prior to 11 weeks' gestation for the indication of advanced maternal age. Group A consisted of 336 patients who were unaware of a possible association between chorionic villus sampling (CVS) and limb defects. Group B consisted of 137 patients who were provided this information. Fifty-one per cent of patients in group A and 45 per cent of patients in group B chose CVS. This difference was not significant by χ2 analysis (P = 0·7). Patterns of prenatal diagnosis procedure utilization from 1987 to 1992 revealed a significant reduction in CVS utilization accompanied by a corresponding increase in amniocentesis after the association between CVS and limb defects was publicized. Referrals for CVS counselling also significantly declined. However, acceptance rates did not change for those patients who received genetic counselling. First-trimester genetic counselling, including a discussion regarding a possible association between CVS and limb defects, helps patients make informed decisions concerning prenatal diagnosis options, and, in our population, resulted in no change in CVS acceptance rates. 相似文献