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51.
Claire Joly Jérôme Gay-Quéheillard André Léké Karen Chardon Stéphane Delanaud Véronique Bach Hafida Khorsi-Cauet 《Environmental science and pollution research international》2013,20(5):2726-2734
The impact of the insecticide chlorpyrifos (CPF) on the mammalian digestive system has been poorly described. The present study aimed at evaluating the effect of chronic, low-dose exposure to CPF on the composition of the gut microbiota in a Simulator of the Human Intestinal Microbial Ecosystem: the SHIME® and in rats. The SHIME® comprises six reactor vessels (stomach to colon). The colonic segments were inoculated with feces from healthy humans. Then, the simulator was exposed to a daily dose of 1 mg of CPF for 30 days. The changes over time in the populations of bacteria were examined at different time points: prior to pesticide exposure (as a control) and after exposure. In parallel, pregnant rats were gavaged daily with 1 mg/kg of CPF (or vehicle) until the pups were weaned. Next, the rats were gavaged with same dose of CPF until 60 days of age (adulthood). Then, samples of different parts of the digestive tract were collected under sterile conditions for microbiological assessment. Chronic, low-dose exposure to CPF in the SHIME® and in the rat was found to induce dysbiosis in the microbial community with, in particular, proliferation of subpopulations of some strains and a decrease in the numbers of others bacteria. In compliance with European guidelines, the use of the SHIME® in vitro tool would help to (1) elucidate the final health effect of toxic agents and (2) minimize (though not fully replace) animal testing. Indeed, certain parameters would still have to be studied further in vivo. 相似文献
52.
Secondary metabolites from bracken fern (Pteridium aquilinum (L.) Kuhn) are suspected of causing cancer in humans. The main carcinogen is the highly water-soluble norsesquiterpene glucoside ptaquiloside, which may be ingested by humans through food, e.g. via contaminated water, meat or milk. It has been postulated that carcinogens could also be ingested through breathing air containing bracken spores. Ptaquiloside has not previously been identified in bracken spores. The aim of the study was to determine whether ptaquiloside is present in bracken spores, and if so, to estimate its content in a collection of spores from Britain. Ptaquiloside was present in all samples, with a maximum of 29 μg g?1, which is very low compared to other parts of the fern. Considering the low abundance of spores in breathing air under normal conditions, this exposure route is likely to be secondary to milk or drinking water. 相似文献
53.
Atmospheric deposition of lead (Pb), zinc (Zn) and cadmium (Cd) was investigated near the former Black Angel Pb–Zn mine in Maarmorilik, West Greenland during 2010–2011. Thalli of the lichen Flavocetraria nivalis were transplanted from an uncontaminated site into sites near the mine and collected the following year. At 20 of the total 21 sites, concentrations of Pb, Zn and Cd were significantly elevated in lichens after 1 year of transplantation compared to initial concentrations. Elevated concentrations were observed within a distance of approx. 20 km from the mining area. Concentrations decreased with increasing distance from the mine and the relation was well described using a power function with a negative exponent (r2 = 0.90; 0.83 and 0.83 for Pb; Zn and Cd). To examine the relation between metal concentrations/uptake in lichen transplants and atmospheric bulk deposition, 10 Bergerhoff dust samplers were placed near lichen transplants and samplers and lichens were collected after a 7-weeks exposure period. A significant linear correlation was observed between metal concentrations in lichen transplants and atmospheric bulk metal deposition (r2 = 0.94; 0.88 and 0.89 for Pb; Zn and Cd). Combining the results and including an area distribution within a defined metal deposition area, the “annual” deposition of Pb, Zn and Cd as dust was estimated during the 2010–2011 snow-free period (~5 months). The results reveal that 20 years after mine closure, 770 kg Pb, 3700 kg Zn and 24 kg Cd were still being deposited as dust per year (snow-free period only) within a distance of 20 km from the mine. 相似文献
54.
Mordechai Shohat MD Edna Akstein Bella Davidov Gad Barkai Cyril Legum Miriam David Hanna Dar Yitzhak Romem Aliza Amiel Hana Cohen Gideon Bach Ziva Ben-Neriah Ruth N. Sheffer Zvi Appelman Juan Chemke Pnina Zadka Tamy Zer Boleslaw Goldman 《黑龙江环境通报》1995,15(10):967-970
We investigated the contribution of different screening criteria to the prenatal detection of Down syndrome (DS) as well as other chromosomal anomalies in the Jewish population in Israel during 1990 and 1992. There was a significant decrease (P<0·03) in the incidence of DS live-births during 1992 (40:78 442) compared with 1990 (69:73 751) which paralleled a marked increase in total prenatal testing and in DS cases detected prenatally. Private laboratories, which perform amniocenteses mostly for women with a low risk of DS and without genetic counselling, had a significantly lower detection rate (1:917) compared with that of the genetic institutes, which following genetic counselling test both women ≥ 37 years of age (1:91) and women younger than 37 years (1:113). The detection of chromosomal anomalies other than DS was less affected by the reason for amniocentesis. Amniocentesis indicated by maternal serum marker screening of women younger than 37 years identified a greater number of chromosomal anomalies other than DS than amniocentesis based on age (≥37 years) alone (111:9604 versus 94:9810; P<0·06). Prenatal detection of DS is most effective when the indication for amniocentesis follows genetic counselling. The increasing use of maternal serum marker screening leads to a significant improvement in the positive detection rate of chromosomal anomalies other than DS in young women. 相似文献
55.
Ana María Murgida Marcela Hebe González Holm Tiessen 《Regional Environmental Change》2014,14(4):1387-1394
Regional change under agricultural expansion in the Chaco of Argentina is determined by interactions of rainfall change, infrastructure development, socio-economic actions and values, and the social perceptions of change. Our study focused on adaptation in the socio-environmental system which is the key to understanding opportunities, uncertainties and risk in the context of historical change. Change in land use from extensive grazing through mixed farming and on to industrial-scale soybean production was made possible by a trend of increasing rainfall that reduced the risk of crop failure from drought since the 1970s. Rainfall change coincided with a period in which the Chaco forest was suffering extensive degradation from long-term extractive use. The degradation aided agricultural expansion since the degraded state of the ecosystem justified public policies of deforestation. In parallel to these resource-based processes, public policy changed in the late 70s and 80s toward favoring privatization of state land and exclusion of small producers. This permitted the land concentration needed for industrial-scale production. Technological innovation in both water and land resource management reinforced the process of concentration because small producers rarely have the financial or educational capital to develop or implement emerging technologies. One of the results of the intensification and expansion of agriculture is that soil surface sealing, waterlogging and flood risk are now effective at a landscape scale. To address these risks, private enterprise and government efforts must now come together toward innovative policies in integrated landscape management. 相似文献
56.
57.
Pesticide pollution of surface waters represents a considerable hazard for the aquatic environment. However, the mean amount of pesticides reaching the water resources varies considerably between regions and depends highly upon application rates, chemical characteristics of pesticides and natural conditions during application. In this study a model was developed which estimates loss of 42 active ingredients applied to 11 field crops, vineyards and orchards along each non-point source path of entry (subsurface drains, runoff and spray drift). A spatially and temporally differentiated data set of application rates and periods was compiled for each active ingredient and target culture to enable the modeling of pesticide transport. The model results are provided in digital raster format (100 m×100 m) within a geographic information system (GIS). The calculated pesticide loads in surface waters were compared with measured loads from different catchments in Germany. Both data sets agreed as to the order of magnitude, nevertheless due to the scale of the study the estimated loads cannot be interpreted as absolute values and only differences between active ingredients, regions and application periods should be assessed. 相似文献
58.
The study comprised 85 young (25–34 years old) women who underwent genetic amniocentesis, 80 comparable young women who had an ultrasoundscan at the same gestational age and 74 women (35–40 years old) who had amniocentesis. The State-Trait Anxiety Inventory and Visual Analogue Scales concerning anxiety and worry were used on four occasions to evaluate psychological changes during pregnancy. The anxiety level in the younger women decreased after amniocentesis and a further decrease was observed after the results were communicated to them. However, similar changes were seen in the group of younger women after ultrasonography, and there was no difference in anxiety level between the two groups of younger women in the 16th or in the 35th week of pregnancy. Thus, in younger women at low genetic risk amniocentesis was neither anxiety-relieving, nor anxiety-creating. The level of anxiety before amniocentesis was not higher in the older than in the younger women having amniocentesis. However, in the younger women a significant decrease in anxiety was seen as soon as amniocentesis had been performed, while in the older women this decrease was delayed until after the results were known. 相似文献
59.
60.
Szefer P Szefer K Pempkowiak J Skwarzec B Bojanowski R Holm E 《Environmental pollution (Barking, Essex : 1987)》1994,83(3):341-349
Zinc, Cu, Cd, Pb, Ag, Ni, Co, Cr, Fe and Mn concentrations in some tissues of crabeater seal (Lobodon carcinophagus), leopard seal (Hydrurga leptonyx) and Weddell seal (Leptonychotes weddelli) from the Antarctic were determined. Distinct inter-tissue differences in metal concentrations in seals were observed; liver contained maximum levels of Zn, Cu, Ag and Mn, whilst kidney showed the highest levels of Cd, Ni and Co. Muscle was characterized by low concentrations of all the elements analyzed. The metal concentrations in the vertebrates analyzed were compared with those for organisms originating from various aquatic areas. Significant correlations were found between the levels of several of the metals analyzed, e.g. between renal and hepatic concentrations of Zn and Cd. Strong relationships between the hepatic concentrations of some metals were found, e.g. Cd-Zn. These two metals also showed a significant coassociation in their renal concentrations. The slope of the regression line for renal Cd/Zn was about three times higher than the hepatic one and this may reflect a relatively high Cd exposure, probably from specific food (squid and krill) provenance, of the seals analyzed. 相似文献