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91.
Maria Paola Iampieri Rita Mingarelli Eric Le Guern Giuseppe Novelli Professor Bruno Dallapiccola 《黑龙江环境通报》1994,14(4):285-289
Five pregnancies at risk for X-linked retinitis pigmentosa (RP) have been monitored by first-trimester prenatal diagnosis using DNA markers flanking the RP2 and RP3 loci. Three affected and two unaffected fetuses, including a female carrying a wild-type genotype, were predicted on the basis of marker segregation and estimation of the recombination fraction. 相似文献
92.
Prenatal diagnosis performed by ultrasound scan is now a routine part of antenatal care in our region. How many fetal anomalies are actually detected by this procedure? We have used our registry of congenital malformations to answer this question regarding limb reduction defects (LRDs). The mean time of detection of LRDs was 26 weeks of pregnancy (range 16–32 weeks). The sensitivity of prenatal diagnosis of LRDs by ultrasonographic examination was much lower for isolated malformations (fetuses with only one anomaly) than for multiply malformed children with LRDs, 4·0 and 18·2 per cent, respectively. For all cases of LRDs, the percentage of prenatal detection was 11·5. Termination of pregnancy was performed in 6·7 per cent of the cases. 相似文献
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Professor K. R. Kunzmann 《Environmental geochemistry and health》1982,4(2-3):99-101
Conclusions Despite these problems there are a number of positive cases, where exemplary solutions have been found after long processes of negotiation and compensation and which can stand as examples of what can be achieved in a re-organisation of the environment and housing structure between the Ruhr and the Lippe.The transformation of the old Rosenblumendelle pit in Mülheim into a shopping centre, the create of a modern industrial park on the land of the old Friedrich Ernestine pit in Essen (from the pit closure to the establishment of the park the whole process only took four and a half years!), and the transformation of the old Dahlhauser Tiefbau pit in Bochum into a leisure and recreation area, which will soon be completed. These and other examples show that reclamation, given favourable circumstances, can be very successful indeed. 相似文献
98.
Professor B. Dallapiccola G. Novelli G. Ferrant A. Pachi M. L. Cristiani M. Magnani 《黑龙江环境通报》1986,6(2):101-107
First trimester prenatal diagnosis was offered to the mother of a child affected by severe haemolytic anaemia due to glucose phosphate isomerase (GPI) deficiency. The mutant enzyme was characterized by an increased thermal lability. Both parents had 50 per cent normal red cell GPI activity. We have shown that the homozygous and heterozygous genotypes can be clearly distinguished from each other and controls by combinations of the measurement of enzyme activity and enzyme thermal lability. Examination of trophoblast cells obtained at 9 weeks of gestation led to the diagnosis of a GPI heterozygous fetus. The result was confirmed by analysis on uncultured and cultured amniotic fluid cells sampled at 16 weeks and by red blood cell studies of the healthy newborn. Prenatal diagnosis of GPI deficiency is indicated in families with previous cases resulting in severe haemolysis and mainly with the conservative view of arranging appropriate therapeutic measures for affected fetuses. 相似文献
99.
Associate Professor Jamie Baxter 《Journal of Environmental Planning and Management》2006,49(3):337-360
Through a qualitative case study, this paper describes the everyday experience of conflict as a serious impact of noxious facilities. It describes intra-community conflict over two existing waste facilities (a regional landfill and a low-level hazardous waste facility) in Ryley, Alberta, Canada. Twenty-seven in-depth face-to-face interviews and one focus group reveal deep conflict presented as frustration, anger, social isolation and strained social relations between locals who ‘support’ the facilities as a means of bolstering the local economy and those who do not (mainly long-time resident farmers). Although the type of hazard exposure (i.e. existing facilities) is important for explaining why conflict developed and became entrenched, it is argued that the nature of community, and in particular differences in ways of life, are also critical determinants. The findings are compared to theory and other case studies concerning why social conflict develops over technological hazards. Implications for environmental impact assessment and environmental appeals are discussed, as well as compensation as one avenue for equitably reducing conflict. 相似文献
100.
Wolfram Elsner Professor of Economics 《Journal of Environmental Planning and Management》2005,48(5):665-690
The paper explores the relations of (1) regionalized climate change impulses; (2) their impacts on regional industry sectors; and (3) a regional econometric impact analysis. It develops a methodology by which the impulses of a regional climate change scenario can be transformed into ‘primary’ impacts on the capital stock and value added of climate-sensitive regional industries. These industries are vulnerable to ‘creeping’, i.e. continuous, climate change impulses, and they tend to react through ‘defensive’ investment. In addition, a singular flooding event is simulated for a specific local area and its different capital stocks. The stock damages and value-added losses of both the continuous industrial impacts and the singular flooding are inserted into a regional econometric model. This is sectorally disaggregated in stock, value-added and investment functions. It is also calibrated in the very-long run (through to the year 2040), according to different scenarios. The regional economic ‘secondary’ effects on the regional GNP are calculated. In addition to the calculation of regional economic primary and secondary impacts, the methodological issue of generating more transparency of the causal chains by use of damage functions, reaction functions, and comparative defensive strategies are discussed. 相似文献