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31.
Effect of chronic exposure to cadmium on hepatic drug metabolism 总被引:1,自引:0,他引:1
In an attempt to examine the chronic effect of low levels of cadmium on hepatic drug-metabolizing enzyme system, an experiment was carried out in which growing male rats were given 0, 5, 10, and 20 ppm of cadmium in drinking water for a period of 8 weeks. An ip administration of a hypnotic dose of pentobarbital to the cadmium-treated and the control rats 24 hr following the termination of the experiment exhibited that there was no significant difference in the drug metabolism in control and any of the treated groups. Next, liver microsomes were isolated from animals in all groups to study their ability to metabolize drugs in vitro. The results indicated that the activity of benzphetamine N-demethylase and aniline hydroxylase, and the concentration of microsomal cytochrome P-450 were almost identical in the control and treated groups. On the other hand, a single ip dose of cadmium (2 mg/kg) caused significant decrease in the vivo and in vitro microsomal drug metabolism. These results suggest that although a single ip dose of cadmium (2 mg/kg) causes significant inhibition of drug metabolism, chronic exposure to cadmium up to 20 ppm in drinking water over a period of 8 weeks is unlikely to affect hepatic drug metabolism. 相似文献
32.
The RNA and DNA contents of the male and female portions of the gonad of the hermaphroditic marine bivalve molluscPecten maximus L. have been monitored throughout an annual reproductive cycle, from October 1985–September 1986, for a population from the Baie de Seine (Normandy, France). The DNA content of the male gonad was consistently 5 to 10 times greater than that of the female gonad, whilst the RNA content was lower. This underlines the basic premise that spermatogenesis involves the production of large numbers of small gametes, whereas oogenesis involves the production of few, large, synthetically active gametes. The RNA:DNA ratio is a good indicator of sexual maturation in the male gonad. Two peaks of RNA:DNA ratio were observed for the female gonad, possibly corresponding to gonad restoration and vitellogenesis. 相似文献
33.
Gary D. Bishop M. Robbins Church Christopher Daly 《Journal of the American Water Resources Association》1998,34(1):159-166
ABSTRACT: We evaluated maps of runoff created by means of two automated procedures. We implemented each procedure using precipitation estimates of both 5-km and 10-km resolution from PRISM (Parameter-elevation Regressions on Independent Slopes Model). Our goal was to determine if using the 5-km PRISM estimates would improve map accuracy. Visual inspection showed good general agreement among our runoff maps, as well as between our maps and one produced using a manual method. A quantitative uncertainty analysis comparing runoff interpolated from our maps with gage data that had been withheld showed slightly smaller actual and percentage interpolation errors for the 5-km PRISM-based maps. Our analyses suggest a modest region-wide improvement in runoff map accuracy with the use of PRISM-based precipitation estimates of 5-km (compared to 10-km) resolution. 相似文献
34.
J.?Howard?ChoatEmail author William?D.?Robbins Kendall?D.?Clements 《Marine Biology》2004,145(3):445-454
Estimates of feeding rates, alimentary tract structure and temporal patterns of food processing obtained from twelve species of nominally herbivorous fishes on the northern Great Barrier Reef were compared. These included members of the families Acanthuridae, Scaridae and Kyphosidae. Based on an analysis of diet and short-chain fatty acid (SCFA) profiles from a previous study we initially partitioned the twelve species into four dietary categories, as follows: (a) Category 1: herbivores with a diet of macroscopic brown algae and high SCFA profiles in the hindgut region (Naso unicornis, Kyphosus vaigiensis); (b) Category 2: herbivores feeding on turfing and filamentous red and green algae with moderate SCFA profiles in the hindgut region (N. tonganus, K. cinerascens, Zebrasoma scopas, Acanthurus lineatus); (c) Category 3: zooplankton feeders with moderate SCFA profiles (N. vlamingii, N. brevirostris); (d) Category 4: species feeding on detrital and sedimentary materials with low levels of SCFA (Chlorurus microrhinos, Scarus schlegeli, Ctenochaetus striatus, A. olivaceus). The purpose of this comparison was to determine whether measures of feeding activity, alimentary tract structure, and food processing were concordant with diet. A dichotomy in feeding rates was observed. Species with a diet of algae and zooplankton (categories 1–3) had slower feeding rates than those feeding on detrital aggregates and sediment (category 4). The pattern of food processing also followed the same dichotomy with species of categories 1–3 retaining food in the alimentary tract overnight and commencing the feeding day with substantial amounts of food in the intestine and hindgut. Category-4 species commenced the feeding day with empty alimentary tracts suggesting a rapid turnover of gut contents. Within the herbivorous and zooplankton-feeding species neither alimentary tract structure nor food processing mode were predicted by diet or SCFA profiles. A hindgut fermentation chamber was present in K. vaigiensis but not in N. unicornis, a species with high levels of SCFA in the hindgut region and a diet of brown macroscopic algae. In contrast N. vlamingii, with a diet dominated by animal matter, retained large amounts of food material in a hindgut chamber over the entire feeding cycle. In tropical perciform fishes, herbivory and fermentation are not associated with the alimentary tract structures that characterise herbivorous terrestrial vertebrates. Estimates of the abundance of the different groupings of nominally herbivorous fishes indicated that the dominant elements in the reef grazing and browsing fauna were consumers of detrital and sedimentary materials. These could not be classified as herbivores. Members of this group were dominant in all habitats investigated. Explicitly herbivorous taxa were a minority component in all habitats investigated.Communicated by G.F. Humphrey, Sydney 相似文献
35.
Serum concentrations of perfluorooctanesulfonate and other fluorochemicals in an elderly population from Seattle, Washington 总被引:14,自引:0,他引:14
Olsen GW Church TR Larson EB van Belle G Lundberg JK Hansen KJ Burris JM Mandel JH Zobel LR 《Chemosphere》2004,54(11):1599-1611
Perfluorooctanesulfonyl fluoride (POSF, C8F17SO2F) related-materials have been used as surfactants, paper and packaging treatments, and surface (e.g., carpet, textile, upholstery) protectants. A metabolite, perfluorooctanesulfonate (PFOS, C8F17SO3−), has been identified in the serum and liver of non-occupationally exposed humans and wildlife. Because of its persistence, an important question was whether elderly humans might have higher PFOS concentrations. From a prospective study designed to examine cognitive function in the Seattle (WA) metropolitan area, blood samples were collected from 238 dementia-free subjects (ages 65–96). High-pressure liquid chromatography-electrospray tandem mass spectrometry determined seven fluorochemicals: PFOS; N-ethyl perfluorooctanesulfonamidoacetate; N-methyl perfluorooctanesulfonamidoacetate; perfluorooctanesulfonamidoacetate; perfluorooctanesulfonamide; perfluorooctanoate; and perfluorohexanesulfonate. Serum PFOS concentrations ranged from less than the lower limit of quantitation (3.4 ppb) to 175.0 ppb (geometric mean 31.0 ppb; 95% CI 28.8–33.4). An estimate of the 95% tolerance limit was 84.1 ppb (upper 95% confidence limit 104.0 ppb). Serum PFOS concentrations were slightly lower among the most elderly. There were no significant differences by sex or years residence in Seattle. The distributions of the other fluorochemicals were approximately an order of magnitude lower. Similar to other reported findings of younger adults, the geometric mean serum PFOS concentration in non-occupational adult populations likely approximates 30–40 ppb with 95% of the population’s serum PFOS concentrations below 100 ppb. 相似文献
36.
The SITES reserve selection system: A critical review 总被引:1,自引:0,他引:1
Douglas?T.?FischerEmail author Richard?L.?Church 《Environmental Modeling and Assessment》2005,10(3):215-228
Numerous models have been put forth to help with the growing demand for the establishment of biodiversity reserves. One site
selection model that has been used in several recent studies is SITES [S.J. Andelman, I. Ball, F.W. Davis and D.M. Stoms,
SITES V 1.0: an analytical toolbox for designing ecoregional conservation portfolios, Unpublished manual prepared for the
nature conservancy, 1999, 1–43. (available at )]. SITES includes two heuristic solvers: based on Greedy and Simulated Annealing. We discuss the formulation of the SITES
model, present a new formulation for that problem, and solve a number of test problems optimally using off-the-shelf software.
We compared our optimal results with the SITES Simulated Annealing heuristic and found that SITES frequently returns significantly
suboptimal solutions. Our results add further support to the argument, started by Underhill [L.G. Underhill, Optimal and suboptimal
reserve selection algorithms, Biol. Conserv. 70 (1994) 85–87], continuing through Rodrigues and Gaston [A.S.L. Rodrigues and
K.J. Gaston, Optimization in reserve selection procedures – why not?, Biol. Conserv. 107 (2002) 123–129], for greater integration
of optimal methods in the reserve design/selection literature. 相似文献
37.
Understanding global sea levels: past, present and future 总被引:4,自引:0,他引:4
John A. Church Neil J. White Thorkild Aarup W. Stanley Wilson Philip L. Woodworth Catia M. Domingues John R. Hunter Kurt Lambeck 《Sustainability Science》2008,3(1):9-22
The coastal zone has changed profoundly during the 20th century and, as a result, society is becoming increasingly vulnerable
to the impact of sea-level rise and variability. This demands improved understanding to facilitate appropriate planning to
minimise potential losses. With this in mind, the World Climate Research Programme organised a workshop (held in June 2006)
to document current understanding and to identify research and observations required to reduce current uncertainties associated
with sea-level rise and variability. While sea levels have varied by over 120 m during glacial/interglacial cycles, there
has been little net rise over the past several millennia until the 19th century and early 20th century, when geological and
tide-gauge data indicate an increase in the rate of sea-level rise. Recent satellite-altimeter data and tide-gauge data have
indicated that sea levels are now rising at over 3 mm year−1. The major contributions to 20th and 21st century sea-level rise are thought to be a result of ocean thermal expansion and
the melting of glaciers and ice caps. Ice sheets are thought to have been a minor contributor to 20th century sea-level rise,
but are potentially the largest contributor in the longer term. Sea levels are currently rising at the upper limit of the
projections of the Third Assessment Report of the Intergovernmental Panel on Climate Change (TAR IPCC), and there is increasing
concern of potentially large ice-sheet contributions during the 21st century and beyond, particularly if greenhouse gas emissions
continue unabated. A suite of ongoing satellite and in situ observational activities need to be sustained and new activities
supported. To the extent that we are able to sustain these observations, research programmes utilising the resulting data
should be able to significantly improve our understanding and narrow projections of future sea-level rise and variability. 相似文献
38.
Deposition of sea salts is commonly elevated along the coast relative to inland areas, yet little is known about the effects on terrestrial ecosystem biogeochemistry. We examined the influence of NaCl concentrations on N, C, and P leaching from a coastal Oregon forest Andisol in two laboratory studies: a rapid batch extraction (approximately 1 d) and a month-long incubation using microlysimeters. In the rapid extractions, salt additions immediately mobilized significant amounts of ammonium and phosphate but not nitrate. In the month-long incubations, salt additions at concentrations in the range of coastal precipitation increased nitrate leaching from the microcosms by nearly 50% and reduced the mobility of dissolved organic carbon. Our findings suggest that coupled abiotic-biotic effects increase nitrate mobility in these soils: exchange of sodium for ammonium, then net nitrification. Changes in sea salt deposition to land and the interactions with coastal soils could alter the delivery of N and C to sensitive coastal waters. 相似文献
39.
Westermann DT Bjorneberg DL Aase JK Robbins CW 《Journal of environmental quality》2001,30(3):1009-1015
Phosphorus (P) often limits the eutrophication of streams, rivers, and lakes receiving surface runoff. We evaluated the relationships among selected soil P availability indices and runoff P fractions where manure, whey, or commercial fertilizer applications had previously established a range of soil P availabilities on a Portneuf silt loam (coarse-silty, mixed, superactive, mesic Durinodic Xeric Haplocalcid) surface-irrigated with Snake River water. Water-soluble P, Olsen P (inorganic and organic P), and iron-oxide impregnated paper-extractable P (FeO-Ps) were determined on a 0.03-m soil sample taken from the bottom of each furrow before each irrigation in fall 1998 and spring 1999. Dissolved reactive phosphorus (DRP) in a 0.45-microm filtered runoff sample, and iron-oxide impregnated paper-extractable P (FeO-Pw), total P, and sediment in an unfiltered runoff sample were determined at selected intervals during a 4-h irrigation on 18.3-m field plots. The 1998 and 1999 data sets were combined because there were no significant differences. Flow-weighted average runoff DRP and FeO-Pw concentrations increased linearly as all three soil P test concentrations increased. The average runoff total P concentration was not related to any soil P test but was linearly related to sediment concentration. Stepwise regression selected the independent variables of sediment, soil lime concentration, and soil organic P extracted by the Olsen method as related to average runoff total P concentration. The average runoff total P concentration was 1.08 mg L(-1) at a soil Olsen P concentration of 10 mg kg(-1). Soil erosion control will be necessary to reduce P losses in surface irrigation runoff. 相似文献
40.
Marwan A. Hassan Michael Church Thomas E. Lisle Francesco Brardinoni Lee Benda Gordon E. Grant 《Journal of the American Water Resources Association》2005,41(4):853-876
This paper reviews sediment transport and channel morphology in small, forested streams in the Pacific Northwest region of North America to assess current knowledge of channel stability and morphology relevant to riparian management practices around small streams. Small channels are defined as ones in which morphology and hydraulics may be significantly influenced by individual clasts or wood materials in the channel. Such channels are headwater channels in close proximity to sediment sources, so they reflect a mix of hillslope and channel processes. Sediment inputs are derived directly from adjacent hillslopes and from the channel banks. Morphologically significant sediments move mainly as bed load, mainly at low intensity, and there is no standard method for measurement. The larger clastic and woody elements in the channel form persistent structures that trap significant volumes of sediment, reducing sediment transport in the short term and substantially increasing channel stability. The presence of such structures makes modeling of sediment flux in these channels — a potential substitute for measurement — difficult. Channel morphology is discussed, with some emphasis on wood related features. The problem of classifying small channels is reviewed, and it is recognized that useful classifications are purpose oriented. Reach scale and channel unit scale morphologies are categorized. A “disturbance cascade” is introduced to focus attention on sediment transfers through the slope channel system and to identify management practices that affect sediment dynamics and consequent channel morphology. Gaps in knowledge, errors, and uncertainties have been identified for future research. 相似文献