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Prenatal ultrasound has concentrated on readily visible cerebral structures including head size, shape, ventricles, CSP (cavum septi pellucidi), cerebellar size/vermian presence and cisterna magna. However, apart from these easily visible structures it is important to evaluate the brain itself. Patients who initially appear to have mild isolated findings such as borderline ventriculomegaly in fact can have many more subtle findings that significantly alter prognosis and management that can be detected on detailed examination of the brain. There has been rapid evolution in imaging these foetuses, especially with neurosonography and MRI, and a revolution in understanding the underlying genetic and biochemical mechanisms. There is increasing emphasis to detect cortical abnormalities as early as possible. This article reviews development of the cerebral cortex, the classification, aetiologies and clinical manifestations of cortical disorders, normal and abnormal appearances at ultrasound and MRI, and approaches to investigation. Copyright © 2009 John Wiley & Sons, Ltd.  相似文献   
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Abstract: The Undergraduate Interagency Resource Teams at the White Mountain Research Station of the University of California were created in 1994 to support resource-agency mandates and academic research objectives by providing qualified students who can learn, apply, and improve research and agency monitoring protocols. Drawing from documented elements of other successful internship programs, we identified four basic components that we believe may enhance the potential success of the interns: (1) self-directed learning methodologies, (2) multidisciplinary approaches to science, (3) reflection on and documentation of intern learning, and (4) principles of a positive work environment, including teamwork, conflict resolution, and effective communication. During a 10-week summer session, the Interagency Resource Teams expose approximately 17 students to the professional worlds of natural resource agencies and research scientists. In this environment, we have also observed that the internship program not only exposes students to resource management careers but may also help bridge the gap between resource agency specialists and academic researchers.  相似文献   
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Molecular genetic surveys of marine fishes have revealed that some widely distributed species are actually a composite of multiple evolutionary lineages. This is apparent in the round herrings (genus Etrumeus), wherein a globally distributed taxon (Etrumeus sadina Mitchill 1814) has proven to contain at least seven valid taxa, with more likely awaiting discovery. Here, we survey evolutionary lineages of the nominal E. sadina (formerly E. teres, a junior synonym) across the southern temperate zone of Australia, a marine region divided into three biogeographic provinces based primarily on the distribution of intertidal faunas. Results from morphological and mitochondrial DNA data reveal two evolutionary lineages corresponding to eastern and southwestern provinces (d = 0.007 for cytochrome c oxidase subunit I and d = 0.017 for cytochrome b), possibly initiated by the Bassian Isthmus between Australia and Tasmania during low sea-level stands. The Australian round herring is also genetically distinct from the nearest congeneric forms in the Indian and Pacific Oceans, with a corresponding modal difference in gill-raker counts in most cases. Based on these data, we resurrect the title Etrumeus jacksoniensis for the Australian round herring. While the Bassian Isthmus may have initiated the partition of evolutionary lineages within Australia, additional oceanographic and ecological factors must reinforce this separation in order to maintain diagnostic genetic differences along a continuous temperate coastline.  相似文献   
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