Ribosomal function and its inhibition by antibiotics in prokaryotes

Most of the known antibiotics act at the level of protein biosynthesis probably due to the extraordinary complexity of the translation machinery which can be interfered with at many points. At first a survey is given of our present knowledge covering the structure and function of the prokaryotic ribosome. The most important antibiotics acting at the translational level are integrated into this network of data. The binding sites and the inhibition mechanisms of the drugs, together with the ribosomal components altered in resistant mutants are described. Finally, the points of interference with the translational machinery are indicated in an extended scheme of ribosomal functions.     

Neue Erkenntnisse auf dem Gebiete der Parasitologie und der parasitären Erkrankungen des Menschen

The increasing interest in the parasites of man in the Federal Republic of Germany is connected with the unbounded keenness of German people to travel. They favor southern regions with warm climates which are usually infested with parasites. Thus the general practitioner is nowadays confronted in his daily routine with “imported” pathogenic organisms and diseases as yet unknown to him or with which he need not have reckoned in the past. Furthermore, new information now exists on the development of well-known parasites of our regions, which can be pathogenic to man. Fortunately, new reliable drugs have come on the market, rendering some parasitic diseases harmless.