Digital PCR: a powerful new tool for noninvasive prenatal diagnosis?

Recent reports have indicated that digital PCR may be useful for the noninvasive detection of fetal aneuploidies by the analysis of cell-free DNA and RNA in maternal plasma or serum. In this review we provide an insight into the underlying technology and its previous application in the determination of the allelic frequencies of oncogenic alterations in cancer specimens. We also provide an indication of how this new technology may prove useful for the detection of fetal aneuploidies and single gene Mendelian disorders. Copyright © 2008 John Wiley & Sons, Ltd.     

Development of Future Generations： Oriented Virtual Negotiation Support System for Intergenerational Conflict

Intergenerational conflict coordination is the fundamental requirement and core of sustainable development. In this paper, through the analysis of the future generations-oriented management mechanisms for intergenerational conflict, the idea of mechanisms and institution building for the coordination and management of intergenerational conflict is put forward. Furthermore, the future generations-oriented virtual negotiation support system （NSS） for intergenerational conflict is developed, built on the analysis of the process simulation of intergenerational wealth transfer, intergenerational equilibrium allocation of resources, and strategies for the mitigation and avoidance of intergenerational conflict, through the application of advanced IT technology. The virtual NSS for intergenerational conflict is helpful to the practical application of the sustainable development theory; on the other hand, it can be applied directly to the intergenerational equilibrium allocation of resources, national economic accounting, formulation of sustainable development strategies and other urgent national economic and social development issues. Finally, the sustainable development theory can be enriched and extended. Therefore, the development of the future generations-oriented virtual NSS for intergenerational conflict has certain theoretical and practical effects on the theory of sustainable development.     

Solution method of overtopping risk model for earth dams

Hydrologic risk analysis relies on a series of probabilistic analyses, and it is a complex problem in estimating the probability distributions of multiple independent and random variables. The goal of this study is to presents the procedure and application of a probability-based risk analysis methodology to evaluate earth dam overtopping risk that induced by concurrent flood and wind. The uncertainty arising from initial water surface level, flood, wind velocity, and dam height are discussed in this research. The improved Monte Carlo simulation and mean-value first-order second-moment method are used to solve the proposed dam overtopping risk model, respectively. The nonparametric kernel density estimation method, which can better learn the complex multimodal characteristic of probability density function than that of traditional parametric estimation method, is employed to improve the probability density function of initial water surface level. The latin hypercube sampling is introduced to generate uniform random number, which improves the efficient and stability compared with simple random sampling. Afterward, an application to the Dongwushi Reservoir in China illustrates that the dam overtopping risk computed using the improved Monte Carlo simulation is lower than that using mean-value first-order second-moment method. Furthermore, the sensitivity analysis show that initial water surface level is more sensitive to overtopping risk than wind velocity.     

农业现代化、信息化与农业面源污染研究

利用2003年-2013年中国30个省份的面板数据,检验了农业现代化、信息化与农业面源污染之间的关系.研究发现,农业现代化对农业面源污染有着一定的加重作用;信息化能够有效缓解因农业现代化所导致的农业面源污染,这一现象在粮食主产省同样存在,说明信息化能够发挥减污增绿的作用;农业环境库兹涅茨曲线(EKC)也得到验证.因此,应进一步推进信息化发展,有效利用信息化对农业现代化所致农业面源污染的缓解作用,还应多措并举促进农民增收,加快农民收入越过EKC曲线拐点.     

水库岸坡变形体灾害的信息评价和预测

较真实地评价水库岸坡的稳定性是工程界普遍关注的问题,本文将工程地质逻辑定性分析和信息法定量分析方法结合起来,对丹江口水库库岸岸坡变形体灾害的信息进行评价和预测,分析结果可供工程设计人员参考。     

农业用地土壤污染防治立法的初探

本文论述了农用地土壤污染防治立法的必要性，立法所具备的条件和应解决的几个基本问题。     

企业物流与安全

按照物流的作用范围 ,可分为社会物流和企业物流。随着物流活动在我国各生产领域不断地推进 ,企业物流合理化、科学化对提高企业的竞争力及促进企业的发展具有重要意义。笔者论述了企业物流与安全生产之间的关系 ,强调企业物流系统在进行设计和改善的同时必须进行安全设计 ,提出了企业物流系统中装卸搬运和仓储两个重要环节的安全技术 ,同时 ,又指出从事安全管理的人员 ,可以通过改善企业物流系统来改善企业安全现状。     

硫化氢的危害与防治

对硫化氢在油气田中的存在状况和危害性的研究结果表明,其主要危害是引起人员中毒以及氢脆作用造成的油田设备腐蚀。详细介绍了防治硫化氢的方法和措施,包括沉淀法、物理吸收法、钾碱法和氨水法、氧化法、金属氧化物吸收法、高压静电法等。对各种方法的防治机理及其应用状况进行了论述。     

大庆地区空气中总烃与非甲烷烃分布规律研究

分析了大庆地区空气中总径与非甲烷烃的比例关系，年、季、日变化规律及浓度水平。说明了总径与非甲烷径浓度水平在采暖期和非采暖期无显著差别，且冬、夏分布大体一致，高浓度多集中于大庆市东北部，浓度值向西南偏南方向递减，总烃总体浓度冬季较夏季偏向于西南这一规律。讨论了气候条件对分布规律的影响，并指出总烂的主要来源是油田开发和机动车尾气排放。