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91.
The potential for xenobiotic compounds to bioconcentrate is typically expressed through the bioconcentration factor (BCF), which has gained increased regulatory significance over the past decade. Due to the expense of in vivo bioconcentration studies and the growing regulatory need to assess bioconcentration potential, BCF is often calculated via single-compartment models, using K(OW) as the primary input. Recent efforts to refine BCF models have focused on physiological factors, including the ability of the organism to eliminate the compound through metabolic transformation. This study looks at the ability of in vitro biotransformation assays using S9 fractions to provide an indication of metabolic potential. Given the importance of the fish gill and liver in metabolic transformation, the metabolic loss of ibuprofen, norethindrone and propranolol was measured using rainbow trout (Oncorhynchus mykiss) and channel catfish (Ictalurus punctatus) gill and liver S9 fractions. Metabolic transformation rates (k(M)) were calculated and integrated into a refined BCF model. A significant difference was noted between BCF solely based on K(OW) and BCF including k(M). These studies indicate that the inclusion of k(M) in BCF models can bring predicted bioconcentration estimates closer to in vivo values. 相似文献
92.
Effects of bis(tributyltin)oxide on antipredator behavior in threespine stickleback Gasterosteus aculeatus L. 总被引:1,自引:0,他引:1
Antipredator behavior was used as a parameter to detect effects caused by exposure to the organotin compound bis(tributyltin)oxide (TBTO). Three groups of threespine sticklebacks (Gasterosteus aculeatus L.) were exposed to 3, 9 and 27 ppb TBTO, respectively. A fourth control group was given the same treatment as the other three groups, but no TBTO. Antipredator behavior of the fish was evoked using a dummy heron (Ardea cinerea) bill. TBTO exposure caused significant changes in the spatial position of the fish in the aquarium (P(Loc)), their response to predator attack (P(Res)), recovery time (P(Rec)) and latency time (P(Lat)). Some of the effects were, however, reversible after the exposure was terminated. We suggest that behavior as an indicator of pollution may be used as an ecologically relevant integrative biomarker. 相似文献
93.
94.
DENNIS D. COX LAWRENCE H. COX KATHERINE B. ENSOR 《Environmental and Ecological Statistics》1997,4(3):219-233
In this paper we summarize research issues for spatial environmental sampling stemming from a NISS/USEPA workshop held on 21-22 September 1994 at Chapel Hill, NC. 相似文献
95.
Heavy metal contamination in the seaweeds of the Venice lagoon 总被引:8,自引:0,他引:8
The concentrations of heavy metals (Fe, Zn, Cu, Cd, Ni, Pb, Cr, As) were determined in seven seaweeds of environmental and commercial relevance (Ulva rigida C. Ag., Gracilaria gracilis (Stackhouse) Steentoft, L. Irvine and Farnham, Porphyra leucosticta Thuret, Grateloupia doryphora (Montagne) Howe., Undaria pinnatifida (Harv.) Suringar, Fucus virsoides J. Agardh, Cystoseira barbata (Good. et Wood.) Ag.) collected in four sampling sites in the lagoon of Venice, in spring and autumn 1999. Metals were extracted using hot concentrated acids in a Microwave Digestion Rotor and analysed by absorption spectrophotometry using a flame mode for Fe and Zn and a graphite furnace for Pb, Cr, Cd, Cu, Ni and As. High contamination levels, especially for Pb, were detected in Ulva and to a lesser extent in Gracilaria. Brown seaweeds, especially Cystoseira was highly contaminated by As. The least contaminated genera with all metals except As were Porphyra and Undaria. A concentration decrease for Zn and Cd was observed from the inner parts of the central lagoon, close to the industrial district, towards the lagoon openings to the sea. 相似文献
96.
Liesbeth Vossaert Imen Chakchouk Roni Zemet Ignatia B. Van den Veyver 《黑龙江环境通报》2021,41(10):1202-1214
Investigators have long been interested in the natural phenomenon of fetal and placental cell trafficking into the maternal circulation. The scarcity of these circulating cells makes their detection and isolation technically challenging. However, as a DNA source of fetal origin not mixed with maternal DNA, they have the potential of considerable benefit over circulating cell-free DNA-based noninvasive prenatal genetic testing (NIPT). Endocervical trophoblasts, which are less rare but more challenging to recover are also being investigated as an approach for cell-based NIPT. We review published studies from around the world describing both forms of cell-based NIPT and highlight the different approaches’ advantages and drawbacks. We also offer guidance for developing a sound cell-based NIPT protocol. 相似文献
97.
98.
Effects of environmental parameters on the oxygen consumption of four marine invertebrates: a comparative factorial study 总被引:1,自引:0,他引:1
The oxygen consumption curves of two decapod crustaceans (Palaemon serratus, Penaeus monodon) and two prosobranch molluscs (Trunculariopsis trunculus, Nassarius mutabilis) have been detected in the entire pO2 interval from 0 to 160 mmHg, under different conditions of temperature and salinity. From the experimental curves, physiological
parameters such as the initial oxygen consumption velocity, the Q
10 values and the oxygen independence indices have been measured. The latter parameters have been obtained using normalised
plots which allow their better evaluation. The effects of temperature, salinity and oxygen partial pressure on the oxygen-consumption
features have been studied using a factorial experimental plan which allows measurement of the effects of each experimental
variable as well as the effects of synergistic interactions between different variables.
Received: 27 March 2000 / Accepted: 13 November 2000 相似文献
99.
Summary. Worker ants of Camponotus socius employ multicomponent signals during group recruitment to food sources and nest emigrations. The chemical signals consist of trail orientation pheromones that originate from the hindgut. Two components that elicit trail orientation behavior were identified: (2S,4R,5S)-2,4-dimethyl-5-hexanolide and 2,3-dihydro-3,5-dihydroxy-6-methylpyran-4-one. Although both compounds release trail following behavior, in choice tests the former compound is preferred significantly. The major recruitment signal appears to be formic acid discharged from the poison gland. Compounds identified in the Dufour gland secretions do not seem to be involved in the recruitment process. 相似文献
100.
Thomas Eisner Daniel J. Aneshansley Jayne Yack Athula B. Attygalle Maria Eisner 《Chemoecology》2001,11(4):209-219
Summary. The defensive glandular apparatus of primitive bombardier beetles of the tribe Crepidogastrini (Carabidae) is described for
the first time. As exemplified by two African species (Crepidogaster ambreana and C. atrata), the apparatus conforms to the basic bombardier plan, in that the glands are bicompartmented and the secretion is quinonoid
(it contains 1,4-benzoquinones and hydrocarbons), hot, and discharged audibly. In a number of morphological respects the crepidogastrine
apparatus resembles that of the classical bombardiers of the tribe Brachinini (rather than that of bombardiers of the paussoid
lineage), reinforcing the view, already held on taxonomic grounds, that the Crepidogastrini and Brachinini are closely related.
That the Crepidogastrini may be primitive relative to Brachinini is underscored by the finding that, unlike brachinines, crepidogastrines
do not pulse their secretory emissions. Moreover, they discharge their secretion as a mist, rather than forcibly in the form
of jets.
Received 22 May 2001; accepted 29 May 2001. 相似文献