Incidence of fetal chromosome abnormalities in 2264 low-risk women

Among a population of 6305 pregnant women, aged 25 to 34 years and estimated to be at no increased risk of genetic disease in the fetus, 4606 women participated in a randomized controlled trial of genetic amniocentesis between 1980 and 1984. In the study group having amniocentesis (2264 women), 23 fetal chromosome abnormalities (1.0 per cent) were found: eight autosomal aneuploidies, seven sex chromosome aneuploidies, seven balanced structural rearrangements and one case of a marker some. The structural rearrangements and the marker chromosome were all shown to be inherited. The study group seemed representative for the whole population of younger women at low genetic risk. Therefore, a 1.0 per cent total rate of fetal chromosome abnormalities, consisting of one-third autosomal aneuploidies, one-third sex chromosome aneuploidies and one-third structural rearrangements, may be expected in the second trimester in younger low-risk women. In the same period of time, 562 women in the same age group were offered amniocentesis because of an estimated increased risk of fetal genetic disease. The total rate of fetal chromosome abnormality in this ‘high-risk’ group was 0.9 per cent and thus no different from the rate in the low-risk group.     

Fetal chromosome analysis: Screening for chromosome disease?

The aim of the study was to investigate the rationale of the current indications for fetal chromosome analysis. 5372 women had 5423 amniocenteses performed, this group constituting a consecutive sample at the chromosome laboratory, Rigshospitalet, Copenhagen from March 1973 to September 1980 (Group A + B). Pregnant women 35 years of age, women who previously had a chromosomally abnormal child, families with translocation carriers or other heritable chromosomal disease, families where the father was 50 years or more and women in families with a history of Down's syndrome (group A), were compared to women having amniocentesis, although considered not to have any increased risk of fetal chromosome abnormality (1390 pregnancies, group B). They were also compared with 750 consecutive pregnancies in women 25–34 years of age, in whom all heritable diseases were excluded (group Q. The risk of unbalanced chromosome abnormality in group A (women with elevated risk) is significantly higher than in group B + C (women without elevated risk) (relative risk 2–4). Women with a known familial translocation and women 40 years or more have a relative risk of 5–7 of having an unbalanced chromosome abnormality compared with women without elevated risk. Spontaneous abortion rate and prematurity rate did not differ from rates expected without amniocentesis. It is concluded that current indications may be characterized as a mixture of evident high risk factors and factors with only a minor influence on risk. Indications for amniocentesis should therefore be reconsidered. Because it must be considered impractical and ethically wrong to limit amniocentesis to the two mentioned real high risk groups, and illogical to continue the present policy, which is not based on clearcut evidence, the possibility of offering amniocentesis to all who want it, is discussed. Screening for chromosome disease in all pregnancies is not without problems, but may be reasonable in some localities.     

Environmental auditing at the crossroads: The environmental auditing roundtable's response to ISO 14000

The Environmental Auditing Roundtable (EAR) is the single largest professional organization in the world, representing over 900 members. Built on a tradition of promoting environmental auditing through openly sharing experiences in the field of safety, health, and environmental auditing, the organization in recent years has significantly expanded its influence on auditing practices both nationally and internationally by monitoring audit activities and participating in the development of audit policy, regulation, standardization, and the certification of environmental auditors. This article describes the origin and evolution of the organization from meeting the needs of the membership to addressing the needs of external national and international stakeholders.     

Comments on selecting a geographic information system for environmental management

Many organizations in environmental fields stand to benefit from the use of a geographic information system (GIS). Selecting a GIS to implement within an organization can be a difficult task that is often required of people with little experience using a GIS. A framework for evaluating competing GIS considers cost, functionality, ease of use, future stability, development potential, support availability, and maintenance costs. Initial cost involves more than the actual purchase price of hardware and software; it includes the cost of building the data base and training users within the organization. Functionality refers to the depth and breadth of capabilities of a GIS. Issues involved in evaluating functionality include the appropriateness of raster vs vector processing and the ability to add your own software. Ease of use is important, but there is generally a trade-off with functionality. The degree of centralization of use of the GIS within the organization affects requirements for ease of use. GIS are rapidly evolving, and as a result it is important to select a system with high potential for future development. With the proliferation of companies offering GIS it is important to select one that is likely to survive and prosper. Similarly, the ability to find support in the forms of technical help, advice, and possibly even skilled employees can be significant.     

Clarifying the definition ofSustainable agriculture

A number of distinct definitions ofsustainable agriculture have been proposed. In this paper we criticize two such definitions, primarily for conflating sustainability with other objectives such as economic viability and ecological integrity. Finally, we propose and defend a definition which avoids our objections to the other definitions.     

THE DEVELOPMENT OF THE NILE HYDROMETEOROLOGICAL FORECAST SYSTEM1

ABSTRACT: The National Oceanic and Atmospheric Administration is developing a river forecast system for the Nile River in Egypt. The river forecast system operates on scientific work stations using hydrometeorological models and software to predict inflows into the high Aswan Dam and forecast flow hydrographs at selected gaging locations above the dam The Nile Forecasting System (NFS) utilizes satellite imagery from the METEOSAT satellite as the input to the forecast system. Satellite imagery is used to estimate precipitation over the Blue Nile Basin using five different techniques. Observed precipitation data and climatic statistics are used to improve precipitation estimation. Precipitation data for grid locations are input to a distributed water balance model, a hill slope routing model, and a channel routing model. A customized Geographic Information System (GIS) was developed to show political boundaries, rivers, terrain elevation, and gaging network. The GIS was used to develop hydrologic parameters for the basin and is used for multiple display features.     

Attributional conflict between managers and subordinates: An investigation of leader-member exchange effects

The present study investigated the discrepancies, or conflict, between the attributions of leaders and members as a function of LMX quality and explored the relation between attributional conflict and subordinate job satisfaction, perceptions of equity, and turnover intentions. Data for the study were provided by 141 supervisor-subordinate dyads from the managerial ranks of a large manufacturing organization. Both parties of the dyad made attributions for subordinate loyalty, affect, and contributions, member behaviors identified as critical in previous LMX research. Limited support emerged for the hypothesis that attributional conflict would be greater in dyads where subordinates reported lower rather than higher LMX quality. Findings suggested that attributional discrepencies are due, in part, to the tendency of leaders to make more favorable attributions for subordinates reporting higher LMX quality than for subordinates reporting lower LMX quality. Results also revealed that, while attributional conflict was negatively related to subordinate satisfaction and perceptions of equity and positively related to turnover intentions, attributional conflict did not predict subordinate work outcomes when the effects of LMX quality were controlled. Implications of these findings were discussed.     

Legal implications in development and use of Expert Systems in agriculture

Applications of Artificial Intelligence, particularly Expert Systems, are rapidly increasing. This science promises to give computer-based systems the capability of reasoning and decision making in near human-like fashion. Whether used for farm management or intelligent machine control, Expert Systems will find many agricultural applications. Much of the development and distribution of such systems will probably take place in the public sector, particularly the Cooperative Extension Service. A major nontechnical factor affecting the development and extensive use of Expert Systems is the legal issue of products, liability, and negligence. The legal issues surrounding Expert Systems have not yet been fully tested and defined by the courts. Developers and users of Expert Systems must consider these factors for each particular application.